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Promote one, inhibit the other: a single pathway controls axon and dendrite growth, oppositely.

Robinson R - PLoS Biol. (2013)

View Article: PubMed Central - PubMed

Affiliation: rrobinson@nasw.org

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These two interact, in that Highwire suppresses expression of Wallenda, and loss of Highwire causes axonal overgrowth that can be reversed by loss of Wallenda... When the authors inactivated Highwire in a set of larval body wall neurons, not only did they observe the expected axon terminal overgrowth, but they also saw dramatic reduction of dendritic growth, leading to dendrites that were both shorter and less highly branched than normal... Conversely, excess of Wallenda favored axon terminal growth and inhibited dendrite growth, strongly suggesting that Highwire and Wallenda work within a single pathway to regulate the growth of both axon and dendrite, with Highwire promoting dendrites and Wallenda axons... At some point, however, the pathway must split, in order to produce its divergent effects... Other experiments have shown that the Fos protein is a downstream effector of Wallenda... Here, inactivation of fos prevented axon terminal overgrowth when Wallenda was overexpressed, indicating it plays a key role in the axonal branch of the pathway... But Fos had no effect on dendritic growth, so the authors speculated that perhaps that branch involved one or more transcription factors with roles in growth of dendrites... They found that levels of one, called Knot, were reduced by either inactivation of Highwire or overexpression of Wallenda... In sum, then, it appears that when Highwire suppresses expression of Wallenda, expression of Knot increases and leads to the elaboration of the dendritic tree... Conversely, when Wallenda expression is elevated, fos is activated and promotes axon terminal outgrowth, while Knot expression is reduced, inhibiting growth of dendrites... One possible benefit of this bimodal control system is to coordinate the response to axonal injury.

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A functioning neuron (symbolized here as a tree) has both dendritic arbors to receive signals and axonal branches to send them.The activity of a single molecular pathway (shown as the orange slope) determines whether a neuron grows more dendrites and fewer axons (left tree) or more axons and fewer dendrites (right tree). Image credit: Xin Wang.
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pbio-1001575-g001: A functioning neuron (symbolized here as a tree) has both dendritic arbors to receive signals and axonal branches to send them.The activity of a single molecular pathway (shown as the orange slope) determines whether a neuron grows more dendrites and fewer axons (left tree) or more axons and fewer dendrites (right tree). Image credit: Xin Wang.


Promote one, inhibit the other: a single pathway controls axon and dendrite growth, oppositely.

Robinson R - PLoS Biol. (2013)

A functioning neuron (symbolized here as a tree) has both dendritic arbors to receive signals and axonal branches to send them.The activity of a single molecular pathway (shown as the orange slope) determines whether a neuron grows more dendrites and fewer axons (left tree) or more axons and fewer dendrites (right tree). Image credit: Xin Wang.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3672213&req=5

pbio-1001575-g001: A functioning neuron (symbolized here as a tree) has both dendritic arbors to receive signals and axonal branches to send them.The activity of a single molecular pathway (shown as the orange slope) determines whether a neuron grows more dendrites and fewer axons (left tree) or more axons and fewer dendrites (right tree). Image credit: Xin Wang.

View Article: PubMed Central - PubMed

Affiliation: rrobinson@nasw.org

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

These two interact, in that Highwire suppresses expression of Wallenda, and loss of Highwire causes axonal overgrowth that can be reversed by loss of Wallenda... When the authors inactivated Highwire in a set of larval body wall neurons, not only did they observe the expected axon terminal overgrowth, but they also saw dramatic reduction of dendritic growth, leading to dendrites that were both shorter and less highly branched than normal... Conversely, excess of Wallenda favored axon terminal growth and inhibited dendrite growth, strongly suggesting that Highwire and Wallenda work within a single pathway to regulate the growth of both axon and dendrite, with Highwire promoting dendrites and Wallenda axons... At some point, however, the pathway must split, in order to produce its divergent effects... Other experiments have shown that the Fos protein is a downstream effector of Wallenda... Here, inactivation of fos prevented axon terminal overgrowth when Wallenda was overexpressed, indicating it plays a key role in the axonal branch of the pathway... But Fos had no effect on dendritic growth, so the authors speculated that perhaps that branch involved one or more transcription factors with roles in growth of dendrites... They found that levels of one, called Knot, were reduced by either inactivation of Highwire or overexpression of Wallenda... In sum, then, it appears that when Highwire suppresses expression of Wallenda, expression of Knot increases and leads to the elaboration of the dendritic tree... Conversely, when Wallenda expression is elevated, fos is activated and promotes axon terminal outgrowth, while Knot expression is reduced, inhibiting growth of dendrites... One possible benefit of this bimodal control system is to coordinate the response to axonal injury.

Show MeSH