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Effects of omega-3 fatty acids on regulatory T cells in hematologic neoplasms.

Betiati Dda S, de Oliveira PF, Camargo Cde Q, Nunes EA, Trindade EB - Rev Bras Hematol Hemoter (2013)

Bottom Line: These, in turn, have divergent actions on the neoplastic process.Populations of T cells have different roles in the neoplastic environment; while interferon-gamma positive T cells have antitumor activity, the FoxP3+interleukin-10 positive population present a pro-tumor activity.Fatty acids can also influence the production of peptide mediators such as cytokines, and the expression of transcription factors, which can determine the production patterns of eicosanoids and cytokines as well as cell differentiation.

View Article: PubMed Central - HTML - PubMed

Affiliation: Universidade Federal de Santa Catarina - UFSC, Florianópolis, SC, Brazil.

ABSTRACT
The development of leukemia and lymphomas is related to the increase in inflammatory process modulators. These, in turn, have divergent actions on the neoplastic process. Populations of T cells have different roles in the neoplastic environment; while interferon-gamma positive T cells have antitumor activity, the FoxP3+interleukin-10 positive population present a pro-tumor activity. Simultaneously, the inflammatory process promotes the mobilization of fatty acids from the cell membrane to produce lipid mediators, which also participate of the inflammatory response. Eicosapentaenoic (EPA) and docosahexaenoic (DHA) omega-3 fatty acids, when incorporated in the plasmatic membrane, decrease the arachidonic acid (AA) metabolism and the production of eicosanoids derived from it. Thus, an alternative family of lipid mediators are produced that are often less inflammatory than those produced from arachidonic acid. Fatty acids can also influence the production of peptide mediators such as cytokines, and the expression of transcription factors, which can determine the production patterns of eicosanoids and cytokines as well as cell differentiation. Due to these properties, the objective of this literature review was to investigate studies published over the last 15 years on the effects of using omega-3 fatty acids on inflammatory markers in leukemia and lymphomas.

No MeSH data available.


Related in: MedlinePlus

Role of the main cytokines in the tumor microenvironment (Adapted fromSeruga(19)
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f02: Role of the main cytokines in the tumor microenvironment (Adapted fromSeruga(19)

Mentions: Additionally, there is coexistence between the malignant cells and the cells of theimmune system. While NK cells and cytotoxic T cells produce IFN-γ and IL-2 inorder to inhibit growth of cancer cells (inhibiting the production of IL-1, IL-6 andTNF-α), the malignant cells themselves secrete cytokines (IL-1, IL-6 andTNF-α) that promote their own proliferation. Furthermore, these cytokinesstimulate macrophages and Tregs to secrete IL-4, IL-10, IL-13 and TGF-β thatwill inhibit the production of cytokines by NK and T cells, causing a suppressanteffect in anticancer immunity (Figure2)(19).


Effects of omega-3 fatty acids on regulatory T cells in hematologic neoplasms.

Betiati Dda S, de Oliveira PF, Camargo Cde Q, Nunes EA, Trindade EB - Rev Bras Hematol Hemoter (2013)

Role of the main cytokines in the tumor microenvironment (Adapted fromSeruga(19)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3672122&req=5

f02: Role of the main cytokines in the tumor microenvironment (Adapted fromSeruga(19)
Mentions: Additionally, there is coexistence between the malignant cells and the cells of theimmune system. While NK cells and cytotoxic T cells produce IFN-γ and IL-2 inorder to inhibit growth of cancer cells (inhibiting the production of IL-1, IL-6 andTNF-α), the malignant cells themselves secrete cytokines (IL-1, IL-6 andTNF-α) that promote their own proliferation. Furthermore, these cytokinesstimulate macrophages and Tregs to secrete IL-4, IL-10, IL-13 and TGF-β thatwill inhibit the production of cytokines by NK and T cells, causing a suppressanteffect in anticancer immunity (Figure2)(19).

Bottom Line: These, in turn, have divergent actions on the neoplastic process.Populations of T cells have different roles in the neoplastic environment; while interferon-gamma positive T cells have antitumor activity, the FoxP3+interleukin-10 positive population present a pro-tumor activity.Fatty acids can also influence the production of peptide mediators such as cytokines, and the expression of transcription factors, which can determine the production patterns of eicosanoids and cytokines as well as cell differentiation.

View Article: PubMed Central - HTML - PubMed

Affiliation: Universidade Federal de Santa Catarina - UFSC, Florianópolis, SC, Brazil.

ABSTRACT
The development of leukemia and lymphomas is related to the increase in inflammatory process modulators. These, in turn, have divergent actions on the neoplastic process. Populations of T cells have different roles in the neoplastic environment; while interferon-gamma positive T cells have antitumor activity, the FoxP3+interleukin-10 positive population present a pro-tumor activity. Simultaneously, the inflammatory process promotes the mobilization of fatty acids from the cell membrane to produce lipid mediators, which also participate of the inflammatory response. Eicosapentaenoic (EPA) and docosahexaenoic (DHA) omega-3 fatty acids, when incorporated in the plasmatic membrane, decrease the arachidonic acid (AA) metabolism and the production of eicosanoids derived from it. Thus, an alternative family of lipid mediators are produced that are often less inflammatory than those produced from arachidonic acid. Fatty acids can also influence the production of peptide mediators such as cytokines, and the expression of transcription factors, which can determine the production patterns of eicosanoids and cytokines as well as cell differentiation. Due to these properties, the objective of this literature review was to investigate studies published over the last 15 years on the effects of using omega-3 fatty acids on inflammatory markers in leukemia and lymphomas.

No MeSH data available.


Related in: MedlinePlus