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Effects of omega-3 fatty acids on regulatory T cells in hematologic neoplasms.

Betiati Dda S, de Oliveira PF, Camargo Cde Q, Nunes EA, Trindade EB - Rev Bras Hematol Hemoter (2013)

Bottom Line: These, in turn, have divergent actions on the neoplastic process.Populations of T cells have different roles in the neoplastic environment; while interferon-gamma positive T cells have antitumor activity, the FoxP3+interleukin-10 positive population present a pro-tumor activity.Fatty acids can also influence the production of peptide mediators such as cytokines, and the expression of transcription factors, which can determine the production patterns of eicosanoids and cytokines as well as cell differentiation.

View Article: PubMed Central - HTML - PubMed

Affiliation: Universidade Federal de Santa Catarina - UFSC, Florianópolis, SC, Brazil.

ABSTRACT
The development of leukemia and lymphomas is related to the increase in inflammatory process modulators. These, in turn, have divergent actions on the neoplastic process. Populations of T cells have different roles in the neoplastic environment; while interferon-gamma positive T cells have antitumor activity, the FoxP3+interleukin-10 positive population present a pro-tumor activity. Simultaneously, the inflammatory process promotes the mobilization of fatty acids from the cell membrane to produce lipid mediators, which also participate of the inflammatory response. Eicosapentaenoic (EPA) and docosahexaenoic (DHA) omega-3 fatty acids, when incorporated in the plasmatic membrane, decrease the arachidonic acid (AA) metabolism and the production of eicosanoids derived from it. Thus, an alternative family of lipid mediators are produced that are often less inflammatory than those produced from arachidonic acid. Fatty acids can also influence the production of peptide mediators such as cytokines, and the expression of transcription factors, which can determine the production patterns of eicosanoids and cytokines as well as cell differentiation. Due to these properties, the objective of this literature review was to investigate studies published over the last 15 years on the effects of using omega-3 fatty acids on inflammatory markers in leukemia and lymphomas.

No MeSH data available.


Related in: MedlinePlus

Synthesis of lipid mediators from arachidonic acid (AA), eicosapentaenoic (EPA)and docosahexaenoic (DHA) omega-3 fatty acids (Adapted from Calder (6))
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f01: Synthesis of lipid mediators from arachidonic acid (AA), eicosapentaenoic (EPA)and docosahexaenoic (DHA) omega-3 fatty acids (Adapted from Calder (6))

Mentions: AA, used as the main substrate to the synthesis of eicosanoids, is one of the mostabundant fatty acids in inflammatory cells. The ω-3 fatty acids, EPA anddocosahexaenoic (DHA), when incorporated into the plasma membrane, reduce themetabolism of AA and thus reduce the eicosanoids derived from it, because they havehigher affinity as substrates for COX-2 and LOX-5. Thus, an alternative family ofeicosanoids starts to be formed which are often less inflammatory than those producedfrom AA. D and E series resolvins are also produced from ω-3 fatty acids; theseare lipid mediators that have a powerful anti-inflammatory action (Figure 1). These fatty acids can influence theproduction of peptide mediators (cytokines) and the expression of transcriptionfactors (such as nuclear factor kappa B - NF-kB) which can determine the productionpattern of cytokines and eicosanoids(6,7). Faber etal.(9) reported that healthyindividuals who take oral supplements containing 2.4 g EPA and 1.2 g of DHA for oneweek, have an increased ex vivo production of IL-1β, tumornecrosis factor alpha (TNF-α), IL-6, IL-8 and interferon-gamma(IFN-γ).


Effects of omega-3 fatty acids on regulatory T cells in hematologic neoplasms.

Betiati Dda S, de Oliveira PF, Camargo Cde Q, Nunes EA, Trindade EB - Rev Bras Hematol Hemoter (2013)

Synthesis of lipid mediators from arachidonic acid (AA), eicosapentaenoic (EPA)and docosahexaenoic (DHA) omega-3 fatty acids (Adapted from Calder (6))
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3672122&req=5

f01: Synthesis of lipid mediators from arachidonic acid (AA), eicosapentaenoic (EPA)and docosahexaenoic (DHA) omega-3 fatty acids (Adapted from Calder (6))
Mentions: AA, used as the main substrate to the synthesis of eicosanoids, is one of the mostabundant fatty acids in inflammatory cells. The ω-3 fatty acids, EPA anddocosahexaenoic (DHA), when incorporated into the plasma membrane, reduce themetabolism of AA and thus reduce the eicosanoids derived from it, because they havehigher affinity as substrates for COX-2 and LOX-5. Thus, an alternative family ofeicosanoids starts to be formed which are often less inflammatory than those producedfrom AA. D and E series resolvins are also produced from ω-3 fatty acids; theseare lipid mediators that have a powerful anti-inflammatory action (Figure 1). These fatty acids can influence theproduction of peptide mediators (cytokines) and the expression of transcriptionfactors (such as nuclear factor kappa B - NF-kB) which can determine the productionpattern of cytokines and eicosanoids(6,7). Faber etal.(9) reported that healthyindividuals who take oral supplements containing 2.4 g EPA and 1.2 g of DHA for oneweek, have an increased ex vivo production of IL-1β, tumornecrosis factor alpha (TNF-α), IL-6, IL-8 and interferon-gamma(IFN-γ).

Bottom Line: These, in turn, have divergent actions on the neoplastic process.Populations of T cells have different roles in the neoplastic environment; while interferon-gamma positive T cells have antitumor activity, the FoxP3+interleukin-10 positive population present a pro-tumor activity.Fatty acids can also influence the production of peptide mediators such as cytokines, and the expression of transcription factors, which can determine the production patterns of eicosanoids and cytokines as well as cell differentiation.

View Article: PubMed Central - HTML - PubMed

Affiliation: Universidade Federal de Santa Catarina - UFSC, Florianópolis, SC, Brazil.

ABSTRACT
The development of leukemia and lymphomas is related to the increase in inflammatory process modulators. These, in turn, have divergent actions on the neoplastic process. Populations of T cells have different roles in the neoplastic environment; while interferon-gamma positive T cells have antitumor activity, the FoxP3+interleukin-10 positive population present a pro-tumor activity. Simultaneously, the inflammatory process promotes the mobilization of fatty acids from the cell membrane to produce lipid mediators, which also participate of the inflammatory response. Eicosapentaenoic (EPA) and docosahexaenoic (DHA) omega-3 fatty acids, when incorporated in the plasmatic membrane, decrease the arachidonic acid (AA) metabolism and the production of eicosanoids derived from it. Thus, an alternative family of lipid mediators are produced that are often less inflammatory than those produced from arachidonic acid. Fatty acids can also influence the production of peptide mediators such as cytokines, and the expression of transcription factors, which can determine the production patterns of eicosanoids and cytokines as well as cell differentiation. Due to these properties, the objective of this literature review was to investigate studies published over the last 15 years on the effects of using omega-3 fatty acids on inflammatory markers in leukemia and lymphomas.

No MeSH data available.


Related in: MedlinePlus