Limits...
Graves' disease in monozygotic twins - a case report.

Rüst CA, Knechtle B, Rosemann T - BMC Endocr Disord (2013)

Bottom Line: We present monozygotic female twins developing consecutively Graves' disease within five years.Both the mother and the twins were cigarette smokers.The twins were treated with carbamizole and this therapy led to normalization of thyroid stimulating hormone and thyroxine.

View Article: PubMed Central - HTML - PubMed

Affiliation: Institute of General Practice and Health Services Research, University of Zurich, Zurich, Switzerland. beat.knechtle@hispeed.ch.

ABSTRACT

Background: Autoimmune thyroid diseases including Graves' disease and Hashimoto's thyroiditis are caused by immune response to self-thyroid antigens. The rare situation of hyperthyroidism with Graves' disease in twins has been reported in a very few case reports in literature.

Case presentation: We present monozygotic female twins developing consecutively Graves' disease within five years. One year before the diagnosis of Graves' disease was established in the first twin, the mother developed a toxic thyroid nodule with hyperthyroidism leading to hemi thyroidectomy. Both the mother and the twins were cigarette smokers. The twins were treated with carbamizole and this therapy led to normalization of thyroid stimulating hormone and thyroxine.

Conclusion: This case report supports the hypothesis that a genetic factor as well as an environmental factor (cigarette smoking) might be of great importance in the aetiology of Graves' disease.

No MeSH data available.


Related in: MedlinePlus

Timeline of TSH and fT4 for twin B.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3672004&req=5

Figure 2: Timeline of TSH and fT4 for twin B.

Mentions: In January 2012, the unmarried twin B aged 32 years went to the family doctor of twin A due to symptoms such as tiredness, dizziness, heart palpitations and sweating. The mother noticed a gaze. The patient herself remarked an increase in the collar size. Laboratory analyses revealed Graves’ disease (Table 1), and a treatment with carbamizole 20 mg per day was started. Due to normalization of fT4 (Figure 2) the dosage of carbamizole was reduced to 15 mg per day. The therapy was continued for one year. In the case history of twin B, varicose vein stripping was done in 2006. She also started smoking cigarettes as a teenager and smokes 5–10 cigarettes per day.


Graves' disease in monozygotic twins - a case report.

Rüst CA, Knechtle B, Rosemann T - BMC Endocr Disord (2013)

Timeline of TSH and fT4 for twin B.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3672004&req=5

Figure 2: Timeline of TSH and fT4 for twin B.
Mentions: In January 2012, the unmarried twin B aged 32 years went to the family doctor of twin A due to symptoms such as tiredness, dizziness, heart palpitations and sweating. The mother noticed a gaze. The patient herself remarked an increase in the collar size. Laboratory analyses revealed Graves’ disease (Table 1), and a treatment with carbamizole 20 mg per day was started. Due to normalization of fT4 (Figure 2) the dosage of carbamizole was reduced to 15 mg per day. The therapy was continued for one year. In the case history of twin B, varicose vein stripping was done in 2006. She also started smoking cigarettes as a teenager and smokes 5–10 cigarettes per day.

Bottom Line: We present monozygotic female twins developing consecutively Graves' disease within five years.Both the mother and the twins were cigarette smokers.The twins were treated with carbamizole and this therapy led to normalization of thyroid stimulating hormone and thyroxine.

View Article: PubMed Central - HTML - PubMed

Affiliation: Institute of General Practice and Health Services Research, University of Zurich, Zurich, Switzerland. beat.knechtle@hispeed.ch.

ABSTRACT

Background: Autoimmune thyroid diseases including Graves' disease and Hashimoto's thyroiditis are caused by immune response to self-thyroid antigens. The rare situation of hyperthyroidism with Graves' disease in twins has been reported in a very few case reports in literature.

Case presentation: We present monozygotic female twins developing consecutively Graves' disease within five years. One year before the diagnosis of Graves' disease was established in the first twin, the mother developed a toxic thyroid nodule with hyperthyroidism leading to hemi thyroidectomy. Both the mother and the twins were cigarette smokers. The twins were treated with carbamizole and this therapy led to normalization of thyroid stimulating hormone and thyroxine.

Conclusion: This case report supports the hypothesis that a genetic factor as well as an environmental factor (cigarette smoking) might be of great importance in the aetiology of Graves' disease.

No MeSH data available.


Related in: MedlinePlus