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The silicon supplement 'Monomethylsilanetriol' is safe and increases the body pool of silicon in healthy Pre-menopausal women.

Jugdaohsingh R, Hui M, Anderson SH, Kinrade SD, Powell JJ - Nutr Metab (Lond) (2013)

Bottom Line: There were no reported adverse effects (i.e. changes to health and well-being) or serum biochemical changes with MMST versus placebo.Our data indicate that oral MMST is safe, is absorbed and undergoes sufficient metabolism in vivo to raise fasting serum silicon levels, consistent with other well absorbed forms of dietary silicon (e.g. orthosilicic acid).It thus appears to be a suitable silicon supplement.

View Article: PubMed Central - HTML - PubMed

Affiliation: MRC Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge, CB1 9NL, UK. ravin.jugdaohsingh@mrc-hnr.cam.ac.uk.

ABSTRACT

Background: Monomethylsilanetriol (MMST) has been used for decades as an oral silicon supplement for bone and connective tissue health, although there are no formal data on its in vivo utilisation or safety following sustained dosing.

Methods: To investigate whether MMST contributes to the body pool of silicon and, secondly, to establish its safety following 4 weeks' supplementation in humans, twenty-two healthy pre-menopausal women (22-38 years) were recruited and supplemented with MMST at the maximum daily recommended dose (10.5 mg Si/day) for 4 weeks in a double-blind, randomised, placebo-controlled, cross-over design (i.e. 8 weeks in total). Fasting serum and urine samples were collected at baseline and at the end of the 4-week supplementation/placebo periods for analysis of total silicon by inductively coupled plasma optical emission spectrometry, MMST by proton nuclear magnetic resonance spectroscopy and full serum biochemistry. Participants also reported on, by questionnaire, their health, well-being and quality of life at 0, 4 and 8 weeks.

Results: Overall, 4-weeks supplementation with MMST significantly increased total fasting Si concentrations in serum and urine (P ≤ 0.003; paired t-test). MMST was semi-quantifiable in serum and quantifiable in urine, but only accounted for ca. 50% and 10%, respectively, of the increased total-Si concentration. There were no reported adverse effects (i.e. changes to health and well-being) or serum biochemical changes with MMST versus placebo.

Conclusions: Our data indicate that oral MMST is safe, is absorbed and undergoes sufficient metabolism in vivo to raise fasting serum silicon levels, consistent with other well absorbed forms of dietary silicon (e.g. orthosilicic acid). It thus appears to be a suitable silicon supplement.

No MeSH data available.


Related in: MedlinePlus

Increase in fasting serum and urinary silicon levels detected as MMST. Increase of total-Si concentration (black bars) and MMST concentration (white bars) in fasting urine (A, n=10) and fasting serum (B, n=6) following 4-week supplementation with MMST. MMST was not detected in the baseline serum samples (detection limit ca. 10 μg/L), but was detected in three of the baseline urine samples (21 ± 7 μg/L; detection limit 3 μg/L).
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Figure 4: Increase in fasting serum and urinary silicon levels detected as MMST. Increase of total-Si concentration (black bars) and MMST concentration (white bars) in fasting urine (A, n=10) and fasting serum (B, n=6) following 4-week supplementation with MMST. MMST was not detected in the baseline serum samples (detection limit ca. 10 μg/L), but was detected in three of the baseline urine samples (21 ± 7 μg/L; detection limit 3 μg/L).

Mentions: We used 1H-NMR to quantitate the concentration of MMST in urine and compared that value to the total-Si increase (as determined by ICP-OES) over and above baseline in the paired samples. MMST was detected above the detection limit (3 μg/L) in all 10 fasting urine samples following supplementation with MMST (Figure 4A). Curiously, MMST was also detected, albeit at much lower concentrations, in three of the five baseline samples (week-0) and three of the four placebo samples (week-4) analysed (data not shown). The concentration of MMST in the 10 fasting urine samples following MMST supplementation accounted for only 10.3 ± 6.6% of the increase in the total-Si excreted, consistent with significant metabolism of the organosilicon to inorganic silicon.


The silicon supplement 'Monomethylsilanetriol' is safe and increases the body pool of silicon in healthy Pre-menopausal women.

Jugdaohsingh R, Hui M, Anderson SH, Kinrade SD, Powell JJ - Nutr Metab (Lond) (2013)

Increase in fasting serum and urinary silicon levels detected as MMST. Increase of total-Si concentration (black bars) and MMST concentration (white bars) in fasting urine (A, n=10) and fasting serum (B, n=6) following 4-week supplementation with MMST. MMST was not detected in the baseline serum samples (detection limit ca. 10 μg/L), but was detected in three of the baseline urine samples (21 ± 7 μg/L; detection limit 3 μg/L).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3649945&req=5

Figure 4: Increase in fasting serum and urinary silicon levels detected as MMST. Increase of total-Si concentration (black bars) and MMST concentration (white bars) in fasting urine (A, n=10) and fasting serum (B, n=6) following 4-week supplementation with MMST. MMST was not detected in the baseline serum samples (detection limit ca. 10 μg/L), but was detected in three of the baseline urine samples (21 ± 7 μg/L; detection limit 3 μg/L).
Mentions: We used 1H-NMR to quantitate the concentration of MMST in urine and compared that value to the total-Si increase (as determined by ICP-OES) over and above baseline in the paired samples. MMST was detected above the detection limit (3 μg/L) in all 10 fasting urine samples following supplementation with MMST (Figure 4A). Curiously, MMST was also detected, albeit at much lower concentrations, in three of the five baseline samples (week-0) and three of the four placebo samples (week-4) analysed (data not shown). The concentration of MMST in the 10 fasting urine samples following MMST supplementation accounted for only 10.3 ± 6.6% of the increase in the total-Si excreted, consistent with significant metabolism of the organosilicon to inorganic silicon.

Bottom Line: There were no reported adverse effects (i.e. changes to health and well-being) or serum biochemical changes with MMST versus placebo.Our data indicate that oral MMST is safe, is absorbed and undergoes sufficient metabolism in vivo to raise fasting serum silicon levels, consistent with other well absorbed forms of dietary silicon (e.g. orthosilicic acid).It thus appears to be a suitable silicon supplement.

View Article: PubMed Central - HTML - PubMed

Affiliation: MRC Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge, CB1 9NL, UK. ravin.jugdaohsingh@mrc-hnr.cam.ac.uk.

ABSTRACT

Background: Monomethylsilanetriol (MMST) has been used for decades as an oral silicon supplement for bone and connective tissue health, although there are no formal data on its in vivo utilisation or safety following sustained dosing.

Methods: To investigate whether MMST contributes to the body pool of silicon and, secondly, to establish its safety following 4 weeks' supplementation in humans, twenty-two healthy pre-menopausal women (22-38 years) were recruited and supplemented with MMST at the maximum daily recommended dose (10.5 mg Si/day) for 4 weeks in a double-blind, randomised, placebo-controlled, cross-over design (i.e. 8 weeks in total). Fasting serum and urine samples were collected at baseline and at the end of the 4-week supplementation/placebo periods for analysis of total silicon by inductively coupled plasma optical emission spectrometry, MMST by proton nuclear magnetic resonance spectroscopy and full serum biochemistry. Participants also reported on, by questionnaire, their health, well-being and quality of life at 0, 4 and 8 weeks.

Results: Overall, 4-weeks supplementation with MMST significantly increased total fasting Si concentrations in serum and urine (P ≤ 0.003; paired t-test). MMST was semi-quantifiable in serum and quantifiable in urine, but only accounted for ca. 50% and 10%, respectively, of the increased total-Si concentration. There were no reported adverse effects (i.e. changes to health and well-being) or serum biochemical changes with MMST versus placebo.

Conclusions: Our data indicate that oral MMST is safe, is absorbed and undergoes sufficient metabolism in vivo to raise fasting serum silicon levels, consistent with other well absorbed forms of dietary silicon (e.g. orthosilicic acid). It thus appears to be a suitable silicon supplement.

No MeSH data available.


Related in: MedlinePlus