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Risk factors for postoperative hypoxemia in patients undergoing Stanford A aortic dissection surgery.

Wang Y, Xue S, Zhu H - J Cardiothorac Surg (2013)

Bottom Line: We found that the incidence of postoperative hypoxemia was 49.5%.Multiple logistic regression analysis showed that preoperative hypoxemia, CA time and transfusion more than 3000 ml were independently associated with postoperative hypoxemia in Stanford A aortic dissection.Preoperative oxygen fraction lower than 200 mmHg, longer CA time and transfusion more than 3000 ml are predictors of postoperative hypoxemia in Stanford A aortic dissection.

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ABSTRACT

Background: The purpose of this study is to identify the risk factors for postoperative hypoxemia in patients with Stanford A aortic dissection surgery and their relation to clinical outcomes.

Methods: Clinical records of 186 patients with postoperative hypoxemia in Stanford A aortic dissection were analyzed retrospectively. The patients were divided into two groups by postoperative oxygen fraction (PaO2/FiO2):hypoxemia group (N=92) and non-hypoxemia group (N=94).

Results: We found that the incidence of postoperative hypoxemia was 49.5%. Statistical analysis by t-test and χ2 indicated that acute onset of the aortic dissection (p=0.000), preoperative oxygen fraction (PaO2/FiO2) ≤200 mmHg(p=0.000), body mass index (p=0.008), circulatory arrest (CA) time (p=0.000) and transfusion more than 3000 ml(p=0.000) were significantly associated with postoperative hypoxemia. Multiple logistic regression analysis showed that preoperative hypoxemia, CA time and transfusion more than 3000 ml were independently associated with postoperative hypoxemia in Stanford A aortic dissection.

Conclusion: Our results suggest that postoperative hypoxemia is a common complication in patients treated by Stanford A aortic dissection surgery. Preoperative oxygen fraction lower than 200 mmHg, longer CA time and transfusion more than 3000 ml are predictors of postoperative hypoxemia in Stanford A aortic dissection.

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Kaplan-Meier survival curve.
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Figure 1: Kaplan-Meier survival curve.

Mentions: All statistical analysis were performed with SPSS16.0 for windows. Quantitative variables were described as mean and standard deviation. The test of homogeneity variance was used for determination of quantitative data distribution. When the distribution of variables was normal, independent samples t-test was used for comparison of quantitative sizes of two independent samples. The dependence of qualitative variable was evaluated by Chi-squared (χ2) criterion. Multivariate stepwise forward logistic regression analysis was adopted to identify independent risk factors for postoperative hypoxemia. Survival was analyzed by the Kaplan-Meier method and log rank test. A p value of less than 0.05 was considered statistically significant. Kaplan-Meier curves were shown in Figure 1.


Risk factors for postoperative hypoxemia in patients undergoing Stanford A aortic dissection surgery.

Wang Y, Xue S, Zhu H - J Cardiothorac Surg (2013)

Kaplan-Meier survival curve.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3649943&req=5

Figure 1: Kaplan-Meier survival curve.
Mentions: All statistical analysis were performed with SPSS16.0 for windows. Quantitative variables were described as mean and standard deviation. The test of homogeneity variance was used for determination of quantitative data distribution. When the distribution of variables was normal, independent samples t-test was used for comparison of quantitative sizes of two independent samples. The dependence of qualitative variable was evaluated by Chi-squared (χ2) criterion. Multivariate stepwise forward logistic regression analysis was adopted to identify independent risk factors for postoperative hypoxemia. Survival was analyzed by the Kaplan-Meier method and log rank test. A p value of less than 0.05 was considered statistically significant. Kaplan-Meier curves were shown in Figure 1.

Bottom Line: We found that the incidence of postoperative hypoxemia was 49.5%.Multiple logistic regression analysis showed that preoperative hypoxemia, CA time and transfusion more than 3000 ml were independently associated with postoperative hypoxemia in Stanford A aortic dissection.Preoperative oxygen fraction lower than 200 mmHg, longer CA time and transfusion more than 3000 ml are predictors of postoperative hypoxemia in Stanford A aortic dissection.

View Article: PubMed Central - HTML - PubMed

ABSTRACT

Background: The purpose of this study is to identify the risk factors for postoperative hypoxemia in patients with Stanford A aortic dissection surgery and their relation to clinical outcomes.

Methods: Clinical records of 186 patients with postoperative hypoxemia in Stanford A aortic dissection were analyzed retrospectively. The patients were divided into two groups by postoperative oxygen fraction (PaO2/FiO2):hypoxemia group (N=92) and non-hypoxemia group (N=94).

Results: We found that the incidence of postoperative hypoxemia was 49.5%. Statistical analysis by t-test and χ2 indicated that acute onset of the aortic dissection (p=0.000), preoperative oxygen fraction (PaO2/FiO2) ≤200 mmHg(p=0.000), body mass index (p=0.008), circulatory arrest (CA) time (p=0.000) and transfusion more than 3000 ml(p=0.000) were significantly associated with postoperative hypoxemia. Multiple logistic regression analysis showed that preoperative hypoxemia, CA time and transfusion more than 3000 ml were independently associated with postoperative hypoxemia in Stanford A aortic dissection.

Conclusion: Our results suggest that postoperative hypoxemia is a common complication in patients treated by Stanford A aortic dissection surgery. Preoperative oxygen fraction lower than 200 mmHg, longer CA time and transfusion more than 3000 ml are predictors of postoperative hypoxemia in Stanford A aortic dissection.

Show MeSH
Related in: MedlinePlus