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Reducing haemorrhagic transformation after thrombolysis for stroke: a strategy utilising minocycline.

Blacker DJ, Prentice D, Alvaro A, Bates TR, Bynevelt M, Kelly A, Kho LK, Kohler E, Hankey GJ, Thompson A, Major T - Stroke Res Treat (2013)

Bottom Line: The primary endpoint is HT diagnosed by brain CT and MRI.Secondary endpoints include clinical outcome measures.Some illustrative cases from the early recruitment phase of this study will be presented, and future perspectives will be discussed.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology and Clinical Neurophysiology, Sir Charles Gairdner Hospital, Nedlands, Western Australia and School of Medicine and Pharmacology, University of Western Australia, Nedlands, WA 6009, Australia.

ABSTRACT
Haemorrhagic transformation (HT) of recently ischaemic brain is a feared complication of thrombolytic therapy that may be caused or compounded by ischaemia-induced activation of matrix metalloproteinases (MMPs). The tetracycline antibiotic minocycline inhibits matrix MMPs and reduces macroscopic HT in rodents with stroke treated with tissue plasminogen activator (tPA). The West Australian Intravenous Minocycline and TPA Stroke Study (WAIMATSS) aims to determine the safety and efficacy of adding minocycline to tPA in acute ischaemic stroke. The WAIMATSS is a multicentre, prospective, and randomised pilot study of intravenous minocycline, 200 mg 12 hourly for 5 doses, compared with standard care, in patients with ischaemic stroke treated with intravenous tPA. The primary endpoint is HT diagnosed by brain CT and MRI. Secondary endpoints include clinical outcome measures. Some illustrative cases from the early recruitment phase of this study will be presented, and future perspectives will be discussed.

No MeSH data available.


Related in: MedlinePlus

Subject presented with mild left hemiparesis. The day one CT (a) and (b) shows a small infarct in the right subcortical white matter, with a suggestion of increased signal within the central portion. The gradient echo (c) and susceptibility weighted image (d) MRI sequences performed on day seven suggest a small amount of blood within the infarct. No clinical deterioration was detected.
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Related In: Results  -  Collection


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fig2: Subject presented with mild left hemiparesis. The day one CT (a) and (b) shows a small infarct in the right subcortical white matter, with a suggestion of increased signal within the central portion. The gradient echo (c) and susceptibility weighted image (d) MRI sequences performed on day seven suggest a small amount of blood within the infarct. No clinical deterioration was detected.

Mentions: In Figure 2 a small amount of blood was visible only on the MRI sequences. Such events will comprise the main data to enable a comparison of the treatment arms.


Reducing haemorrhagic transformation after thrombolysis for stroke: a strategy utilising minocycline.

Blacker DJ, Prentice D, Alvaro A, Bates TR, Bynevelt M, Kelly A, Kho LK, Kohler E, Hankey GJ, Thompson A, Major T - Stroke Res Treat (2013)

Subject presented with mild left hemiparesis. The day one CT (a) and (b) shows a small infarct in the right subcortical white matter, with a suggestion of increased signal within the central portion. The gradient echo (c) and susceptibility weighted image (d) MRI sequences performed on day seven suggest a small amount of blood within the infarct. No clinical deterioration was detected.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3649751&req=5

fig2: Subject presented with mild left hemiparesis. The day one CT (a) and (b) shows a small infarct in the right subcortical white matter, with a suggestion of increased signal within the central portion. The gradient echo (c) and susceptibility weighted image (d) MRI sequences performed on day seven suggest a small amount of blood within the infarct. No clinical deterioration was detected.
Mentions: In Figure 2 a small amount of blood was visible only on the MRI sequences. Such events will comprise the main data to enable a comparison of the treatment arms.

Bottom Line: The primary endpoint is HT diagnosed by brain CT and MRI.Secondary endpoints include clinical outcome measures.Some illustrative cases from the early recruitment phase of this study will be presented, and future perspectives will be discussed.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology and Clinical Neurophysiology, Sir Charles Gairdner Hospital, Nedlands, Western Australia and School of Medicine and Pharmacology, University of Western Australia, Nedlands, WA 6009, Australia.

ABSTRACT
Haemorrhagic transformation (HT) of recently ischaemic brain is a feared complication of thrombolytic therapy that may be caused or compounded by ischaemia-induced activation of matrix metalloproteinases (MMPs). The tetracycline antibiotic minocycline inhibits matrix MMPs and reduces macroscopic HT in rodents with stroke treated with tissue plasminogen activator (tPA). The West Australian Intravenous Minocycline and TPA Stroke Study (WAIMATSS) aims to determine the safety and efficacy of adding minocycline to tPA in acute ischaemic stroke. The WAIMATSS is a multicentre, prospective, and randomised pilot study of intravenous minocycline, 200 mg 12 hourly for 5 doses, compared with standard care, in patients with ischaemic stroke treated with intravenous tPA. The primary endpoint is HT diagnosed by brain CT and MRI. Secondary endpoints include clinical outcome measures. Some illustrative cases from the early recruitment phase of this study will be presented, and future perspectives will be discussed.

No MeSH data available.


Related in: MedlinePlus