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Reducing haemorrhagic transformation after thrombolysis for stroke: a strategy utilising minocycline.

Blacker DJ, Prentice D, Alvaro A, Bates TR, Bynevelt M, Kelly A, Kho LK, Kohler E, Hankey GJ, Thompson A, Major T - Stroke Res Treat (2013)

Bottom Line: The primary endpoint is HT diagnosed by brain CT and MRI.Secondary endpoints include clinical outcome measures.Some illustrative cases from the early recruitment phase of this study will be presented, and future perspectives will be discussed.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology and Clinical Neurophysiology, Sir Charles Gairdner Hospital, Nedlands, Western Australia and School of Medicine and Pharmacology, University of Western Australia, Nedlands, WA 6009, Australia.

ABSTRACT
Haemorrhagic transformation (HT) of recently ischaemic brain is a feared complication of thrombolytic therapy that may be caused or compounded by ischaemia-induced activation of matrix metalloproteinases (MMPs). The tetracycline antibiotic minocycline inhibits matrix MMPs and reduces macroscopic HT in rodents with stroke treated with tissue plasminogen activator (tPA). The West Australian Intravenous Minocycline and TPA Stroke Study (WAIMATSS) aims to determine the safety and efficacy of adding minocycline to tPA in acute ischaemic stroke. The WAIMATSS is a multicentre, prospective, and randomised pilot study of intravenous minocycline, 200 mg 12 hourly for 5 doses, compared with standard care, in patients with ischaemic stroke treated with intravenous tPA. The primary endpoint is HT diagnosed by brain CT and MRI. Secondary endpoints include clinical outcome measures. Some illustrative cases from the early recruitment phase of this study will be presented, and future perspectives will be discussed.

No MeSH data available.


Related in: MedlinePlus

Subject presented with acute left hemiparesis, leg more affected than arm. Routine day one CT (a) and day 5 MRI (b) demonstrate a small haemorrhage in the left temporal lobe, away from the main area of infarction, shown on diffusion weighted MRI (c) and (d), mainly in the territory of the right anterior cerebral artery. No clinical deterioration was detected.
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Related In: Results  -  Collection


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fig1: Subject presented with acute left hemiparesis, leg more affected than arm. Routine day one CT (a) and day 5 MRI (b) demonstrate a small haemorrhage in the left temporal lobe, away from the main area of infarction, shown on diffusion weighted MRI (c) and (d), mainly in the territory of the right anterior cerebral artery. No clinical deterioration was detected.

Mentions: In Figure 1 blood was detected on CT and MRI in a region away from the infarction.


Reducing haemorrhagic transformation after thrombolysis for stroke: a strategy utilising minocycline.

Blacker DJ, Prentice D, Alvaro A, Bates TR, Bynevelt M, Kelly A, Kho LK, Kohler E, Hankey GJ, Thompson A, Major T - Stroke Res Treat (2013)

Subject presented with acute left hemiparesis, leg more affected than arm. Routine day one CT (a) and day 5 MRI (b) demonstrate a small haemorrhage in the left temporal lobe, away from the main area of infarction, shown on diffusion weighted MRI (c) and (d), mainly in the territory of the right anterior cerebral artery. No clinical deterioration was detected.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3649751&req=5

fig1: Subject presented with acute left hemiparesis, leg more affected than arm. Routine day one CT (a) and day 5 MRI (b) demonstrate a small haemorrhage in the left temporal lobe, away from the main area of infarction, shown on diffusion weighted MRI (c) and (d), mainly in the territory of the right anterior cerebral artery. No clinical deterioration was detected.
Mentions: In Figure 1 blood was detected on CT and MRI in a region away from the infarction.

Bottom Line: The primary endpoint is HT diagnosed by brain CT and MRI.Secondary endpoints include clinical outcome measures.Some illustrative cases from the early recruitment phase of this study will be presented, and future perspectives will be discussed.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology and Clinical Neurophysiology, Sir Charles Gairdner Hospital, Nedlands, Western Australia and School of Medicine and Pharmacology, University of Western Australia, Nedlands, WA 6009, Australia.

ABSTRACT
Haemorrhagic transformation (HT) of recently ischaemic brain is a feared complication of thrombolytic therapy that may be caused or compounded by ischaemia-induced activation of matrix metalloproteinases (MMPs). The tetracycline antibiotic minocycline inhibits matrix MMPs and reduces macroscopic HT in rodents with stroke treated with tissue plasminogen activator (tPA). The West Australian Intravenous Minocycline and TPA Stroke Study (WAIMATSS) aims to determine the safety and efficacy of adding minocycline to tPA in acute ischaemic stroke. The WAIMATSS is a multicentre, prospective, and randomised pilot study of intravenous minocycline, 200 mg 12 hourly for 5 doses, compared with standard care, in patients with ischaemic stroke treated with intravenous tPA. The primary endpoint is HT diagnosed by brain CT and MRI. Secondary endpoints include clinical outcome measures. Some illustrative cases from the early recruitment phase of this study will be presented, and future perspectives will be discussed.

No MeSH data available.


Related in: MedlinePlus