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Comparison Study of Airway Reactivity Outcomes due to a Pharmacologic Challenge Test: Impulse Oscillometry versus Least Mean Squared Analysis Techniques.

Rodriguez E, Bullard CM, Armani MH, Miller TL, Shaffer TH - Pulm Med (2013)

Bottom Line: The technique of measuring transpulmonary pressure and respiratory airflow with manometry and pneumotachography using the least mean squared analysis (LMS) has been used broadly in both preclinical and clinical settings for the evaluation of neonatal respiratory function during tidal volume breathing for lung tissue and airway frictional mechanical properties measurements.Whereas the technique of measuring respiratory function using the impulse oscillation technique (IOS) involves the assessment of the relationship between pressure and flow using an impulse signal with a range of frequencies, requires less cooperation and provides more information on total respiratory system resistance (chest wall, lung tissue, and airways).The present study represents a preclinical animal study to determine whether these respiratory function techniques (LMS and IOS) are comparable in detecting changes in respiratory resistance derived from a direct pharmacological challenge.

View Article: PubMed Central - PubMed

Affiliation: Nemours Research Lung Center, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE 19803, USA ; Nemours Biomedical Research, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE 19803, USA ; Division of Clinical Pharmacology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

ABSTRACT
The technique of measuring transpulmonary pressure and respiratory airflow with manometry and pneumotachography using the least mean squared analysis (LMS) has been used broadly in both preclinical and clinical settings for the evaluation of neonatal respiratory function during tidal volume breathing for lung tissue and airway frictional mechanical properties measurements. Whereas the technique of measuring respiratory function using the impulse oscillation technique (IOS) involves the assessment of the relationship between pressure and flow using an impulse signal with a range of frequencies, requires less cooperation and provides more information on total respiratory system resistance (chest wall, lung tissue, and airways). The present study represents a preclinical animal study to determine whether these respiratory function techniques (LMS and IOS) are comparable in detecting changes in respiratory resistance derived from a direct pharmacological challenge.

No MeSH data available.


Related in: MedlinePlus

Bland-Altman plots constructed from the least mean square (LMS) and impulse oscillometry (IOS) data at each specific frequency (percentage of change) with mean (bias), ±LOA, and best-fit values of linear regression (slope, r2, P value) after administration of intravenous bethanechol. LOA, limit of agreement; Upper LOA, mean difference (bias) + 1.96 SD; Lower LOA, mean difference (bias) −1.96 SD; r2, R squares. The P value is testing the  hypothesis that the overall slope is zero.
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fig5: Bland-Altman plots constructed from the least mean square (LMS) and impulse oscillometry (IOS) data at each specific frequency (percentage of change) with mean (bias), ±LOA, and best-fit values of linear regression (slope, r2, P value) after administration of intravenous bethanechol. LOA, limit of agreement; Upper LOA, mean difference (bias) + 1.96 SD; Lower LOA, mean difference (bias) −1.96 SD; r2, R squares. The P value is testing the hypothesis that the overall slope is zero.

Mentions: The Bland-Altman analysis demonstrated that 95% of the differences between methods (IOS and LMS) lay within ±1.96 SD from the mean difference indicated by the LOA. Overall, there was a consistent linear sloped trend with a systematic bias (negative bias presented at lower values and positive bias presented at higher values of the measurement range) across the Bland-Altman plots, but within the LOA (Figure 5); this effect becomes less biased towards lower frequencies (Figures 5(a) and 5(b)) as do the slopes of the linear regression analysis.


Comparison Study of Airway Reactivity Outcomes due to a Pharmacologic Challenge Test: Impulse Oscillometry versus Least Mean Squared Analysis Techniques.

Rodriguez E, Bullard CM, Armani MH, Miller TL, Shaffer TH - Pulm Med (2013)

Bland-Altman plots constructed from the least mean square (LMS) and impulse oscillometry (IOS) data at each specific frequency (percentage of change) with mean (bias), ±LOA, and best-fit values of linear regression (slope, r2, P value) after administration of intravenous bethanechol. LOA, limit of agreement; Upper LOA, mean difference (bias) + 1.96 SD; Lower LOA, mean difference (bias) −1.96 SD; r2, R squares. The P value is testing the  hypothesis that the overall slope is zero.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3649693&req=5

fig5: Bland-Altman plots constructed from the least mean square (LMS) and impulse oscillometry (IOS) data at each specific frequency (percentage of change) with mean (bias), ±LOA, and best-fit values of linear regression (slope, r2, P value) after administration of intravenous bethanechol. LOA, limit of agreement; Upper LOA, mean difference (bias) + 1.96 SD; Lower LOA, mean difference (bias) −1.96 SD; r2, R squares. The P value is testing the hypothesis that the overall slope is zero.
Mentions: The Bland-Altman analysis demonstrated that 95% of the differences between methods (IOS and LMS) lay within ±1.96 SD from the mean difference indicated by the LOA. Overall, there was a consistent linear sloped trend with a systematic bias (negative bias presented at lower values and positive bias presented at higher values of the measurement range) across the Bland-Altman plots, but within the LOA (Figure 5); this effect becomes less biased towards lower frequencies (Figures 5(a) and 5(b)) as do the slopes of the linear regression analysis.

Bottom Line: The technique of measuring transpulmonary pressure and respiratory airflow with manometry and pneumotachography using the least mean squared analysis (LMS) has been used broadly in both preclinical and clinical settings for the evaluation of neonatal respiratory function during tidal volume breathing for lung tissue and airway frictional mechanical properties measurements.Whereas the technique of measuring respiratory function using the impulse oscillation technique (IOS) involves the assessment of the relationship between pressure and flow using an impulse signal with a range of frequencies, requires less cooperation and provides more information on total respiratory system resistance (chest wall, lung tissue, and airways).The present study represents a preclinical animal study to determine whether these respiratory function techniques (LMS and IOS) are comparable in detecting changes in respiratory resistance derived from a direct pharmacological challenge.

View Article: PubMed Central - PubMed

Affiliation: Nemours Research Lung Center, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE 19803, USA ; Nemours Biomedical Research, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE 19803, USA ; Division of Clinical Pharmacology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

ABSTRACT
The technique of measuring transpulmonary pressure and respiratory airflow with manometry and pneumotachography using the least mean squared analysis (LMS) has been used broadly in both preclinical and clinical settings for the evaluation of neonatal respiratory function during tidal volume breathing for lung tissue and airway frictional mechanical properties measurements. Whereas the technique of measuring respiratory function using the impulse oscillation technique (IOS) involves the assessment of the relationship between pressure and flow using an impulse signal with a range of frequencies, requires less cooperation and provides more information on total respiratory system resistance (chest wall, lung tissue, and airways). The present study represents a preclinical animal study to determine whether these respiratory function techniques (LMS and IOS) are comparable in detecting changes in respiratory resistance derived from a direct pharmacological challenge.

No MeSH data available.


Related in: MedlinePlus