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Comparison Study of Airway Reactivity Outcomes due to a Pharmacologic Challenge Test: Impulse Oscillometry versus Least Mean Squared Analysis Techniques.

Rodriguez E, Bullard CM, Armani MH, Miller TL, Shaffer TH - Pulm Med (2013)

Bottom Line: The technique of measuring transpulmonary pressure and respiratory airflow with manometry and pneumotachography using the least mean squared analysis (LMS) has been used broadly in both preclinical and clinical settings for the evaluation of neonatal respiratory function during tidal volume breathing for lung tissue and airway frictional mechanical properties measurements.Whereas the technique of measuring respiratory function using the impulse oscillation technique (IOS) involves the assessment of the relationship between pressure and flow using an impulse signal with a range of frequencies, requires less cooperation and provides more information on total respiratory system resistance (chest wall, lung tissue, and airways).The present study represents a preclinical animal study to determine whether these respiratory function techniques (LMS and IOS) are comparable in detecting changes in respiratory resistance derived from a direct pharmacological challenge.

View Article: PubMed Central - PubMed

Affiliation: Nemours Research Lung Center, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE 19803, USA ; Nemours Biomedical Research, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE 19803, USA ; Division of Clinical Pharmacology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

ABSTRACT
The technique of measuring transpulmonary pressure and respiratory airflow with manometry and pneumotachography using the least mean squared analysis (LMS) has been used broadly in both preclinical and clinical settings for the evaluation of neonatal respiratory function during tidal volume breathing for lung tissue and airway frictional mechanical properties measurements. Whereas the technique of measuring respiratory function using the impulse oscillation technique (IOS) involves the assessment of the relationship between pressure and flow using an impulse signal with a range of frequencies, requires less cooperation and provides more information on total respiratory system resistance (chest wall, lung tissue, and airways). The present study represents a preclinical animal study to determine whether these respiratory function techniques (LMS and IOS) are comparable in detecting changes in respiratory resistance derived from a direct pharmacological challenge.

No MeSH data available.


Plots of mean values for respiratory resistance (Rrs) from 10 Hz to 25 Hz before (pre) and after (post) bethanechol for each piglet. P = 0.018, paired t-test one tailed for the average.
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fig3: Plots of mean values for respiratory resistance (Rrs) from 10 Hz to 25 Hz before (pre) and after (post) bethanechol for each piglet. P = 0.018, paired t-test one tailed for the average.

Mentions: Following bethanechol administration, a significant overall increase in the respiratory resistance measured by IOS was demonstrated by positive changes in Rrs from 10 to 25 Hz (+96%, P = 0.018; Figure 3). Significant increases in specific respiratory resistances were demonstrated by positive changes in the intermediate frequency spectrum (frequencies: Rrs 10 Hz [+106%, P = 0.031], Rrs 15 Hz [+96%, P = 0.013], Rrs 20 Hz [+95%, P = 0.026], and Rrs 25 Hz [+85%, P = 0.037]). No statistically significant differences between the prebethanechol (pre) and postbethanechol (post) outcomes for any remaining frequencies were observed: Rrs 3 Hz (+67%, P = 0.131), Rrs 5 Hz (+67%, P = 0.09), and Rrs 35 Hz (+95%, P = 0.084), and the resistance spectrum of Rrs demonstrated increased positive frequency dependence (Figure 4).


Comparison Study of Airway Reactivity Outcomes due to a Pharmacologic Challenge Test: Impulse Oscillometry versus Least Mean Squared Analysis Techniques.

Rodriguez E, Bullard CM, Armani MH, Miller TL, Shaffer TH - Pulm Med (2013)

Plots of mean values for respiratory resistance (Rrs) from 10 Hz to 25 Hz before (pre) and after (post) bethanechol for each piglet. P = 0.018, paired t-test one tailed for the average.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3649693&req=5

fig3: Plots of mean values for respiratory resistance (Rrs) from 10 Hz to 25 Hz before (pre) and after (post) bethanechol for each piglet. P = 0.018, paired t-test one tailed for the average.
Mentions: Following bethanechol administration, a significant overall increase in the respiratory resistance measured by IOS was demonstrated by positive changes in Rrs from 10 to 25 Hz (+96%, P = 0.018; Figure 3). Significant increases in specific respiratory resistances were demonstrated by positive changes in the intermediate frequency spectrum (frequencies: Rrs 10 Hz [+106%, P = 0.031], Rrs 15 Hz [+96%, P = 0.013], Rrs 20 Hz [+95%, P = 0.026], and Rrs 25 Hz [+85%, P = 0.037]). No statistically significant differences between the prebethanechol (pre) and postbethanechol (post) outcomes for any remaining frequencies were observed: Rrs 3 Hz (+67%, P = 0.131), Rrs 5 Hz (+67%, P = 0.09), and Rrs 35 Hz (+95%, P = 0.084), and the resistance spectrum of Rrs demonstrated increased positive frequency dependence (Figure 4).

Bottom Line: The technique of measuring transpulmonary pressure and respiratory airflow with manometry and pneumotachography using the least mean squared analysis (LMS) has been used broadly in both preclinical and clinical settings for the evaluation of neonatal respiratory function during tidal volume breathing for lung tissue and airway frictional mechanical properties measurements.Whereas the technique of measuring respiratory function using the impulse oscillation technique (IOS) involves the assessment of the relationship between pressure and flow using an impulse signal with a range of frequencies, requires less cooperation and provides more information on total respiratory system resistance (chest wall, lung tissue, and airways).The present study represents a preclinical animal study to determine whether these respiratory function techniques (LMS and IOS) are comparable in detecting changes in respiratory resistance derived from a direct pharmacological challenge.

View Article: PubMed Central - PubMed

Affiliation: Nemours Research Lung Center, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE 19803, USA ; Nemours Biomedical Research, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE 19803, USA ; Division of Clinical Pharmacology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

ABSTRACT
The technique of measuring transpulmonary pressure and respiratory airflow with manometry and pneumotachography using the least mean squared analysis (LMS) has been used broadly in both preclinical and clinical settings for the evaluation of neonatal respiratory function during tidal volume breathing for lung tissue and airway frictional mechanical properties measurements. Whereas the technique of measuring respiratory function using the impulse oscillation technique (IOS) involves the assessment of the relationship between pressure and flow using an impulse signal with a range of frequencies, requires less cooperation and provides more information on total respiratory system resistance (chest wall, lung tissue, and airways). The present study represents a preclinical animal study to determine whether these respiratory function techniques (LMS and IOS) are comparable in detecting changes in respiratory resistance derived from a direct pharmacological challenge.

No MeSH data available.