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Assessing cue-induced brain response as a function of abstinence duration in heroin-dependent individuals: an event-related fMRI study.

Li Q, Wang Y, Zhang Y, Li W, Zhu J, Zheng Y, Chen J, Zhao L, Zhou Z, Liu Y, Wang W, Tian J - PLoS ONE (2013)

Bottom Line: The self-reported craving scores were significantly increased after cue exposure in the short-term abstinent patients (t = 3.000, P = 0.008), but no increase was found in the long-term abstinent patients (t = 1.510, P = 0.149).However, no significant differences in cue-induced craving changes were found between the two groups (t = 1.193, P = 0.850).Comparing between the long-term abstinence and short-term abstinence groups, significant decreases in brain activation were detected in the bilateral anterior cingulated cortex, left medial prefrontal cortex, caudate, middle occipital gyrus, inferior parietal lobule and right precuneus.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Tangdu Hospital, the Fourth Military Medical University, Xi'an, China.

ABSTRACT
The brain activity induced by heroin-related cues may play a role in the maintenance of heroin dependence. Whether the reinforcement or processing biases construct an everlasting feature of heroin addiction remains to be resolved. We used an event-related fMRI paradigm to measure brain activation in response to heroin cue-related pictures versus neutral pictures as the control condition in heroin-dependent patients undergoing short-term and long-term abstinence. The self-reported craving scores were significantly increased after cue exposure in the short-term abstinent patients (t = 3.000, P = 0.008), but no increase was found in the long-term abstinent patients (t = 1.510, P = 0.149). However, no significant differences in cue-induced craving changes were found between the two groups (t = 1.193, P = 0.850). Comparing between the long-term abstinence and short-term abstinence groups, significant decreases in brain activation were detected in the bilateral anterior cingulated cortex, left medial prefrontal cortex, caudate, middle occipital gyrus, inferior parietal lobule and right precuneus. Among all of the heroin dependent patients, the abstinence duration was negatively correlated with brain activation in the left medial prefrontal cortex and left inferior parietal lobule. These findings suggest that long-term abstinence may be useful for heroin-dependent patients to diminish their saliency value of heroin-related cues and possibly lower the relapse vulnerability to some extent.

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Related in: MedlinePlus

The activated regions relating to the “Heroin-Neutral” contrast for the SA group (P<0.05, corrected for Monte Carlo simulations).
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pone-0062911-g001: The activated regions relating to the “Heroin-Neutral” contrast for the SA group (P<0.05, corrected for Monte Carlo simulations).

Mentions: In the SA group, the significantly activated brain regions relating to the “Heroin-Neutral” contrast included the bilateral nucleus accumbens (NAc), caudate, DLPFC, OFC, MPFC, superior frontal gyrus (SFG), precentral gyrus (PrG), amygdala, pons, midbrain, middle cingulate cortex (MCC), fusiform, PCC, precuneus, thalamus, middle occipital gyrus (MOG), middle temporal gyrus (MTG), inferior temporal gyrus (ITG), inferior parietal lobule (IPL), left ACC, hippocampus, insula, inferior occipital gyrus (IOG), angular gyrus and cerebellum (Figure 1 and Table S1). In the LA group, the significantly activated brain regions included the left amygdala, inferior occipital gyrus (IOG), superior parietal lobule (SPL) and right parahippocampal gyrus, angular gyrus and bilateral fusiform, IPL, ITG, MTG, MOG and cerebellum (Table 2 and Figure 2).


Assessing cue-induced brain response as a function of abstinence duration in heroin-dependent individuals: an event-related fMRI study.

Li Q, Wang Y, Zhang Y, Li W, Zhu J, Zheng Y, Chen J, Zhao L, Zhou Z, Liu Y, Wang W, Tian J - PLoS ONE (2013)

The activated regions relating to the “Heroin-Neutral” contrast for the SA group (P<0.05, corrected for Monte Carlo simulations).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3646913&req=5

pone-0062911-g001: The activated regions relating to the “Heroin-Neutral” contrast for the SA group (P<0.05, corrected for Monte Carlo simulations).
Mentions: In the SA group, the significantly activated brain regions relating to the “Heroin-Neutral” contrast included the bilateral nucleus accumbens (NAc), caudate, DLPFC, OFC, MPFC, superior frontal gyrus (SFG), precentral gyrus (PrG), amygdala, pons, midbrain, middle cingulate cortex (MCC), fusiform, PCC, precuneus, thalamus, middle occipital gyrus (MOG), middle temporal gyrus (MTG), inferior temporal gyrus (ITG), inferior parietal lobule (IPL), left ACC, hippocampus, insula, inferior occipital gyrus (IOG), angular gyrus and cerebellum (Figure 1 and Table S1). In the LA group, the significantly activated brain regions included the left amygdala, inferior occipital gyrus (IOG), superior parietal lobule (SPL) and right parahippocampal gyrus, angular gyrus and bilateral fusiform, IPL, ITG, MTG, MOG and cerebellum (Table 2 and Figure 2).

Bottom Line: The self-reported craving scores were significantly increased after cue exposure in the short-term abstinent patients (t = 3.000, P = 0.008), but no increase was found in the long-term abstinent patients (t = 1.510, P = 0.149).However, no significant differences in cue-induced craving changes were found between the two groups (t = 1.193, P = 0.850).Comparing between the long-term abstinence and short-term abstinence groups, significant decreases in brain activation were detected in the bilateral anterior cingulated cortex, left medial prefrontal cortex, caudate, middle occipital gyrus, inferior parietal lobule and right precuneus.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Tangdu Hospital, the Fourth Military Medical University, Xi'an, China.

ABSTRACT
The brain activity induced by heroin-related cues may play a role in the maintenance of heroin dependence. Whether the reinforcement or processing biases construct an everlasting feature of heroin addiction remains to be resolved. We used an event-related fMRI paradigm to measure brain activation in response to heroin cue-related pictures versus neutral pictures as the control condition in heroin-dependent patients undergoing short-term and long-term abstinence. The self-reported craving scores were significantly increased after cue exposure in the short-term abstinent patients (t = 3.000, P = 0.008), but no increase was found in the long-term abstinent patients (t = 1.510, P = 0.149). However, no significant differences in cue-induced craving changes were found between the two groups (t = 1.193, P = 0.850). Comparing between the long-term abstinence and short-term abstinence groups, significant decreases in brain activation were detected in the bilateral anterior cingulated cortex, left medial prefrontal cortex, caudate, middle occipital gyrus, inferior parietal lobule and right precuneus. Among all of the heroin dependent patients, the abstinence duration was negatively correlated with brain activation in the left medial prefrontal cortex and left inferior parietal lobule. These findings suggest that long-term abstinence may be useful for heroin-dependent patients to diminish their saliency value of heroin-related cues and possibly lower the relapse vulnerability to some extent.

Show MeSH
Related in: MedlinePlus