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Protective role of Helicobacter pylori infection in prognosis of gastric cancer: evidence from 2,454 patients with gastric cancer.

Wang F, Sun G, Zou Y, Zhong F, Ma T, Li X - PLoS ONE (2013)

Bottom Line: There was no evidence of publication bias.This meta-analysis suggests a protective role for H. pylori infection in the prognosis of GC.The underlying mechanisms need to be further elucidated, which could provide new therapeutic approaches for GC.

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.

ABSTRACT

Background: A number of studies have investigated the association between Helicobacter pylori (H. pylori) infection and the prognosis of gastric cancer (GC), with inconsistent and inconclusive results. We performed a meta-analysis to derive a more precise estimation of the association.

Methodology/principal findings: A systematic search of PubMed, EMBASE, Cochrane and Chinese wanfang databases was performed with the last search updated on February 19, 2013. The hazard ratio (HR) and its 95% confidence interval (95%CI) were used to assess the strength of association. A total of 12 studies including 2454 patients with GC were involved in this meta-analysis. The pooled HR was 0.71 (95%CI: 0.57-0.87; P = 0.001) for OS and 0.60 (95%CI: 0.30-1.18; P = 0.139) for DFS in GC patients, respectively. The protective role of H. pylori infection in the prognosis of GC was also observed among different subgroups stratified by ethnicity, statistical methodology, H. pylori evaluation method and quality assessment. There was no evidence of publication bias.

Conclusions/significance: This meta-analysis suggests a protective role for H. pylori infection in the prognosis of GC. The underlying mechanisms need to be further elucidated, which could provide new therapeutic approaches for GC.

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Related in: MedlinePlus

The flow chart of the included studies in the meta-analysis.
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pone-0062440-g001: The flow chart of the included studies in the meta-analysis.

Mentions: Our systematic literature search yielded a total of 12 studies associated with H. pylori infection and the prognosis of GC in the final analysis [8]–[19]. Figure 1 illustrates the search process and the final selection of relevant studies. Of the 1529 potential relevant records after duplications removed, 1510 records were excluded after we had reviewed the titles and abstracts. After carefully reviewing the remaining 19 studies [8]–[19], [28]–[34], a total of 12 studies were eligible for the final analysis. Five conference abstracts were excluded for duplicate reports [28]–[32]. There were two studies from the same population, both reported by Lee et al. [8], [33]. Under this circumstance, the study with larger sample size was included [8], while the other study was excluded due to overlapping data-set [33]. The study by Zhang et al. [34] was excluded because it focused on patients with proximal gastric carcinoma involving the esophagus (PGCE).


Protective role of Helicobacter pylori infection in prognosis of gastric cancer: evidence from 2,454 patients with gastric cancer.

Wang F, Sun G, Zou Y, Zhong F, Ma T, Li X - PLoS ONE (2013)

The flow chart of the included studies in the meta-analysis.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3646839&req=5

pone-0062440-g001: The flow chart of the included studies in the meta-analysis.
Mentions: Our systematic literature search yielded a total of 12 studies associated with H. pylori infection and the prognosis of GC in the final analysis [8]–[19]. Figure 1 illustrates the search process and the final selection of relevant studies. Of the 1529 potential relevant records after duplications removed, 1510 records were excluded after we had reviewed the titles and abstracts. After carefully reviewing the remaining 19 studies [8]–[19], [28]–[34], a total of 12 studies were eligible for the final analysis. Five conference abstracts were excluded for duplicate reports [28]–[32]. There were two studies from the same population, both reported by Lee et al. [8], [33]. Under this circumstance, the study with larger sample size was included [8], while the other study was excluded due to overlapping data-set [33]. The study by Zhang et al. [34] was excluded because it focused on patients with proximal gastric carcinoma involving the esophagus (PGCE).

Bottom Line: There was no evidence of publication bias.This meta-analysis suggests a protective role for H. pylori infection in the prognosis of GC.The underlying mechanisms need to be further elucidated, which could provide new therapeutic approaches for GC.

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.

ABSTRACT

Background: A number of studies have investigated the association between Helicobacter pylori (H. pylori) infection and the prognosis of gastric cancer (GC), with inconsistent and inconclusive results. We performed a meta-analysis to derive a more precise estimation of the association.

Methodology/principal findings: A systematic search of PubMed, EMBASE, Cochrane and Chinese wanfang databases was performed with the last search updated on February 19, 2013. The hazard ratio (HR) and its 95% confidence interval (95%CI) were used to assess the strength of association. A total of 12 studies including 2454 patients with GC were involved in this meta-analysis. The pooled HR was 0.71 (95%CI: 0.57-0.87; P = 0.001) for OS and 0.60 (95%CI: 0.30-1.18; P = 0.139) for DFS in GC patients, respectively. The protective role of H. pylori infection in the prognosis of GC was also observed among different subgroups stratified by ethnicity, statistical methodology, H. pylori evaluation method and quality assessment. There was no evidence of publication bias.

Conclusions/significance: This meta-analysis suggests a protective role for H. pylori infection in the prognosis of GC. The underlying mechanisms need to be further elucidated, which could provide new therapeutic approaches for GC.

Show MeSH
Related in: MedlinePlus