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Design and validation of a method to determine the position of the fovea by using the nerve-head to fovea distance of the fellow eye.

van de Put MA, Nayebi F, Croonen D, Nolte IM, Japing WJ, Hooymans JM, Los LI - PLoS ONE (2013)

Bottom Line: The effect of age, gender, and refractive error on NFD was analysed.We found a significant effect of age (center of the nerve-head (P = 0.006) and rim of the nerve head (P = 0.003)) and refractive error (center of nerve-head (P<0.001) and rim of nerve head (P<0.001)) on NFD.Age and refractive error have an effect on NFD.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. m.a.j.van.de.put@umcg.nl

ABSTRACT

Purpose: To measure the nerve-head to fovea distance (NFD) on fundus photographs in fellow eyes, and to compare the NFD between fellow eyes.

Methods: Diabetic patients without retinopathy, (n = 183) who were screened by fundus photography at the University Medical Center Groningen, the Netherlands from January 1(st) 2005 until January 1(st) 2006 were included. The NFD was measured in left and right eyes both from the center and from the rim of the nerve-head. To determine inter- and intra-observer agreement, repeated measurements by one observer (n = 3) were performed on all photographs and by two observers on 60 photographs (30 paired eyes). The effect of age, gender, and refractive error on NFD was analysed.

Results: The correlation of NFDs between the left and the right eye was 0.958 when measured from the center of the nerve head (mean difference 0.0078 mm. ±SD 0.079 (95% limits of agreement -0.147-0.163)) and 0.963 when measured from the rim (mean difference 0.0056±SD 0.073 (95% limits of agreement -0.137-0.149)). Using the NFD between fellow eyes interchangeably, resulted in a standard error of 0.153 mm. Intra- and inter-observer variability was small. We found a significant effect of age (center of the nerve-head (P = 0.006) and rim of the nerve head (P = 0.003)) and refractive error (center of nerve-head (P<0.001) and rim of nerve head (P<0.001)) on NFD.

Conclusions: The NFD in one eye provides a confident, reproducible, and valid method to address the position of the fovea in the fellow eye. We recommend using the NFD measured from the center of the nerve-head since the standard error by this method was smallest. Age and refractive error have an effect on NFD.

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The age of 183 patients plotted against the mean NFD measured form the center of the nerve-head of both eyes (ODS) together with the line of equation (N = 183).
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pone-0062518-g005: The age of 183 patients plotted against the mean NFD measured form the center of the nerve-head of both eyes (ODS) together with the line of equation (N = 183).

Mentions: There was no significant difference in NFD between males and females. There was a significant effect of age and refraction on NFD. When measured from the center of the nerve-head, we found that NFD decreased by 0.062 mm (P<0.001) per unit increase in spherical equivalent of refraction (Figure 4), and NFD decreased with aging by 0.0029 mm (P = 0.006) per year of age (R2 = 0.206) (Figure 5). When measuring NFD from the rim of the nerve-head we observed a decrease in NFD by 0.050 mm (P<0.001) per unit increase in spherical equivalent of refraction and by 0.0031 mm (P = 0.003) per year of age (R2 = 0.165).


Design and validation of a method to determine the position of the fovea by using the nerve-head to fovea distance of the fellow eye.

van de Put MA, Nayebi F, Croonen D, Nolte IM, Japing WJ, Hooymans JM, Los LI - PLoS ONE (2013)

The age of 183 patients plotted against the mean NFD measured form the center of the nerve-head of both eyes (ODS) together with the line of equation (N = 183).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3646827&req=5

pone-0062518-g005: The age of 183 patients plotted against the mean NFD measured form the center of the nerve-head of both eyes (ODS) together with the line of equation (N = 183).
Mentions: There was no significant difference in NFD between males and females. There was a significant effect of age and refraction on NFD. When measured from the center of the nerve-head, we found that NFD decreased by 0.062 mm (P<0.001) per unit increase in spherical equivalent of refraction (Figure 4), and NFD decreased with aging by 0.0029 mm (P = 0.006) per year of age (R2 = 0.206) (Figure 5). When measuring NFD from the rim of the nerve-head we observed a decrease in NFD by 0.050 mm (P<0.001) per unit increase in spherical equivalent of refraction and by 0.0031 mm (P = 0.003) per year of age (R2 = 0.165).

Bottom Line: The effect of age, gender, and refractive error on NFD was analysed.We found a significant effect of age (center of the nerve-head (P = 0.006) and rim of the nerve head (P = 0.003)) and refractive error (center of nerve-head (P<0.001) and rim of nerve head (P<0.001)) on NFD.Age and refractive error have an effect on NFD.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. m.a.j.van.de.put@umcg.nl

ABSTRACT

Purpose: To measure the nerve-head to fovea distance (NFD) on fundus photographs in fellow eyes, and to compare the NFD between fellow eyes.

Methods: Diabetic patients without retinopathy, (n = 183) who were screened by fundus photography at the University Medical Center Groningen, the Netherlands from January 1(st) 2005 until January 1(st) 2006 were included. The NFD was measured in left and right eyes both from the center and from the rim of the nerve-head. To determine inter- and intra-observer agreement, repeated measurements by one observer (n = 3) were performed on all photographs and by two observers on 60 photographs (30 paired eyes). The effect of age, gender, and refractive error on NFD was analysed.

Results: The correlation of NFDs between the left and the right eye was 0.958 when measured from the center of the nerve head (mean difference 0.0078 mm. ±SD 0.079 (95% limits of agreement -0.147-0.163)) and 0.963 when measured from the rim (mean difference 0.0056±SD 0.073 (95% limits of agreement -0.137-0.149)). Using the NFD between fellow eyes interchangeably, resulted in a standard error of 0.153 mm. Intra- and inter-observer variability was small. We found a significant effect of age (center of the nerve-head (P = 0.006) and rim of the nerve head (P = 0.003)) and refractive error (center of nerve-head (P<0.001) and rim of nerve head (P<0.001)) on NFD.

Conclusions: The NFD in one eye provides a confident, reproducible, and valid method to address the position of the fovea in the fellow eye. We recommend using the NFD measured from the center of the nerve-head since the standard error by this method was smallest. Age and refractive error have an effect on NFD.

Show MeSH
Related in: MedlinePlus