Limits...
Exposure levels of environmental endocrine disruptors in mother-newborn pairs in China and their placental transfer characteristics.

Li LX, Chen L, Meng XZ, Chen BH, Chen SQ, Zhao Y, Zhao LF, Liang Y, Zhang YH - PLoS ONE (2013)

Bottom Line: The placenta is expected to be an effective barrier protecting the developing embryo against some endocrine disruptors (EDs) circulating in maternal blood.In contrast, PBDEs levels in cord blood samples were significantly higher than those in maternal blood.MEHP levels in meconium were much higher than those in cord blood samples, and highly correlated.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Public Health Safety, Ministry of Education, School of Public Health, Fudan University, Shanghai, China.

ABSTRACT
There is a growing concern about the potential health effects of exposure to various environmental chemicals during pregnancy and infancy. The placenta is expected to be an effective barrier protecting the developing embryo against some endocrine disruptors (EDs) circulating in maternal blood. The current study was designed to assess in utero exposure levels of non-persistent organic pollutants (non-POPs) and persistent organic pollutants (POPs) in Chinese newborns and potential role of placenta barrier against fetal exposure to these commonly-used environmental endocrine disruptors. A total of 230 newborn-mother pairs were enrolled during 2010-2011, 201 pairs of which were recruited from Shanghai, and the other 29 pairs came from Wenzhou. Maternal blood, cord blood, and meconium specimens were collected in the subject population from Shanghai and analyzed for non-POPs, including mono-2-ethylhexyl phthalate (MEHP), octylphenol (OP) and 4-nonylphenol (4-NP). A total of 19 polybrominated diphenyl ethers (PBDEs) congeners, which belong to POPs, were detected in maternal and cord blood specimens from the other 29 pairs. Fetal-maternal ratios (F-M ratios) and regression coefficients were presented to assess potential function of placenta on barricading the mother/fetal transfer of these EDs. Concentrations of the detected non-POPs in cord blood samples were approximately 20% lower than those in maternal blood, and regression coefficients of which were all over 0.80. In contrast, PBDEs levels in cord blood samples were significantly higher than those in maternal blood. MEHP levels in meconium were much higher than those in cord blood samples, and highly correlated. Therefore, observations demonstrated that the placental barrier slightly decreased the fetal exposure to most non-POPs, while PBDEs seemed to be totally transferred across the placenta and finally reached the fetus. For in utero exposure assessment of Di-2-ethylhexyl phthalate (DEHP), MEHP level in meconium may be a useful biomarker.

Show MeSH

Related in: MedlinePlus

Regression analysis between non-POPs levels in maternal and cord blood. Regression analysis was used to analyze the relationship between these EDs levels in maternal and cord blood. (A) The relationship between MEHP levels in maternal and cord blood. The regression coefficient was 0.807, meaning that about 80% MEHP could cross the placenta; (B) The relationship between OP levels in maternal and cord blood. The regression coefficient was 0.846, meaning that about 85% OP could go through the placenta; (C) The relationship between 4-NP levels in maternal and cord blood. The regression coefficient was 0.862, meaning that more than 86% 4-NP could cross the placenta.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3646826&req=5

pone-0062526-g004: Regression analysis between non-POPs levels in maternal and cord blood. Regression analysis was used to analyze the relationship between these EDs levels in maternal and cord blood. (A) The relationship between MEHP levels in maternal and cord blood. The regression coefficient was 0.807, meaning that about 80% MEHP could cross the placenta; (B) The relationship between OP levels in maternal and cord blood. The regression coefficient was 0.846, meaning that about 85% OP could go through the placenta; (C) The relationship between 4-NP levels in maternal and cord blood. The regression coefficient was 0.862, meaning that more than 86% 4-NP could cross the placenta.

Mentions: After controlling for the potential confounders (including gestational age, smoking, socioeconomic level, and prepregnancy BMI), regression analysis was used to analyze the relationship between these EDs levels in maternal and cord blood, and good correlations between the two specimens could be demonstrated by regression coefficients (Figure 4). The regression coefficients of all the non-POPs were over 0.80, indicating these EDs can cross the placenta to a great extent.


Exposure levels of environmental endocrine disruptors in mother-newborn pairs in China and their placental transfer characteristics.

Li LX, Chen L, Meng XZ, Chen BH, Chen SQ, Zhao Y, Zhao LF, Liang Y, Zhang YH - PLoS ONE (2013)

Regression analysis between non-POPs levels in maternal and cord blood. Regression analysis was used to analyze the relationship between these EDs levels in maternal and cord blood. (A) The relationship between MEHP levels in maternal and cord blood. The regression coefficient was 0.807, meaning that about 80% MEHP could cross the placenta; (B) The relationship between OP levels in maternal and cord blood. The regression coefficient was 0.846, meaning that about 85% OP could go through the placenta; (C) The relationship between 4-NP levels in maternal and cord blood. The regression coefficient was 0.862, meaning that more than 86% 4-NP could cross the placenta.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3646826&req=5

pone-0062526-g004: Regression analysis between non-POPs levels in maternal and cord blood. Regression analysis was used to analyze the relationship between these EDs levels in maternal and cord blood. (A) The relationship between MEHP levels in maternal and cord blood. The regression coefficient was 0.807, meaning that about 80% MEHP could cross the placenta; (B) The relationship between OP levels in maternal and cord blood. The regression coefficient was 0.846, meaning that about 85% OP could go through the placenta; (C) The relationship between 4-NP levels in maternal and cord blood. The regression coefficient was 0.862, meaning that more than 86% 4-NP could cross the placenta.
Mentions: After controlling for the potential confounders (including gestational age, smoking, socioeconomic level, and prepregnancy BMI), regression analysis was used to analyze the relationship between these EDs levels in maternal and cord blood, and good correlations between the two specimens could be demonstrated by regression coefficients (Figure 4). The regression coefficients of all the non-POPs were over 0.80, indicating these EDs can cross the placenta to a great extent.

Bottom Line: The placenta is expected to be an effective barrier protecting the developing embryo against some endocrine disruptors (EDs) circulating in maternal blood.In contrast, PBDEs levels in cord blood samples were significantly higher than those in maternal blood.MEHP levels in meconium were much higher than those in cord blood samples, and highly correlated.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Public Health Safety, Ministry of Education, School of Public Health, Fudan University, Shanghai, China.

ABSTRACT
There is a growing concern about the potential health effects of exposure to various environmental chemicals during pregnancy and infancy. The placenta is expected to be an effective barrier protecting the developing embryo against some endocrine disruptors (EDs) circulating in maternal blood. The current study was designed to assess in utero exposure levels of non-persistent organic pollutants (non-POPs) and persistent organic pollutants (POPs) in Chinese newborns and potential role of placenta barrier against fetal exposure to these commonly-used environmental endocrine disruptors. A total of 230 newborn-mother pairs were enrolled during 2010-2011, 201 pairs of which were recruited from Shanghai, and the other 29 pairs came from Wenzhou. Maternal blood, cord blood, and meconium specimens were collected in the subject population from Shanghai and analyzed for non-POPs, including mono-2-ethylhexyl phthalate (MEHP), octylphenol (OP) and 4-nonylphenol (4-NP). A total of 19 polybrominated diphenyl ethers (PBDEs) congeners, which belong to POPs, were detected in maternal and cord blood specimens from the other 29 pairs. Fetal-maternal ratios (F-M ratios) and regression coefficients were presented to assess potential function of placenta on barricading the mother/fetal transfer of these EDs. Concentrations of the detected non-POPs in cord blood samples were approximately 20% lower than those in maternal blood, and regression coefficients of which were all over 0.80. In contrast, PBDEs levels in cord blood samples were significantly higher than those in maternal blood. MEHP levels in meconium were much higher than those in cord blood samples, and highly correlated. Therefore, observations demonstrated that the placental barrier slightly decreased the fetal exposure to most non-POPs, while PBDEs seemed to be totally transferred across the placenta and finally reached the fetus. For in utero exposure assessment of Di-2-ethylhexyl phthalate (DEHP), MEHP level in meconium may be a useful biomarker.

Show MeSH
Related in: MedlinePlus