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The relationship between P3 amplitude and working memory performance differs in young and older adults.

Saliasi E, Geerligs L, Lorist MM, Maurits NM - PLoS ONE (2013)

Bottom Line: Among young adults, more efficient performance correlated with a larger P3 amplitude at parietal sites.In contrast, a higher P3 amplitude at midline electrode sites in older adults correlated with less efficient performance.Particularly, the enhanced frontal midline EEG activity in older adults during working memory performance seems to reflect inefficient use of neural resources due to frontal lobe dysfunction.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. e.saliasi@umcg.nl

ABSTRACT
While some elderly show deteriorations in cognitive performance, others achieve performance levels comparable to young adults. To examine whether age-related changes in brain activity varied with working memory performance efficiency, we recorded electroencephalography (EEG) from young and older healthy adults during performance on an n-back task with two loads (0- and 1-back) and two versions (identity and integrated). Young adults showed a typical P3 amplitude pattern with a parietal-maximum. Compared to young adults, the P3 amplitude of older adults was characterized by frontal hyperactivity coupled with posterior hypoactivity. Moreover, P3 amplitude in young and older adults varied with working memory performance efficiency. Among young adults, more efficient performance correlated with a larger P3 amplitude at parietal sites. In contrast, a higher P3 amplitude at midline electrode sites in older adults correlated with less efficient performance. Particularly, the enhanced frontal midline EEG activity in older adults during working memory performance seems to reflect inefficient use of neural resources due to frontal lobe dysfunction.

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Related in: MedlinePlus

Behavioral results comprised of mean RTs (bars) in milliseconds (ms) and accuracy scores (lines) in percentages (%) for young (black) and old (grey) adults.Behavioral outcomes are presented, separately, for the 0-back and the 1-back load in the identity version and in the integrated version.
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pone-0063701-g002: Behavioral results comprised of mean RTs (bars) in milliseconds (ms) and accuracy scores (lines) in percentages (%) for young (black) and old (grey) adults.Behavioral outcomes are presented, separately, for the 0-back and the 1-back load in the identity version and in the integrated version.

Mentions: Mean accuracy scores and RTs for young and older adults, for the different task conditions are illustrated in Figure 2. The estimated proportion of correct responses was higher in the 0-back (92%) than in the 1-back load condition (90%; βintercept  = 2.33; z  = 34, p<0.0005; βload  = −.35; z  = −7.7, p<0.0001). However, this load effect was modulated by age and version (βage*load*version  = −.62; z  = −3.4, p<0.001). For older adults, the estimated proportion of correct responses was higher in the 0-back than in the 1-back load condition, in both versions (identity: 92.6% vs. 87.6%; βintercept identity version in the 0-back load  = 2.54 z  = 20.1, p<0.0001; β1-back  = −.55; z  = −6.14, p<0.0001 and integrated: 92.4% vs. 88.5%; βintercept integrated version in the 0-back load  = 2.49, z  = 17.91, p<0.0001; β1-back  = −46; z  = −5.25; p<0.0001). For young adults, this load effect was limited to the integrated version (93.6% vs. 90%; βintercept integrated version in the 0-back load  = 2.66, z  = 24.22, p<0.0001; β1-back  = −.47; z  = −4.98, p<0.0001).


The relationship between P3 amplitude and working memory performance differs in young and older adults.

Saliasi E, Geerligs L, Lorist MM, Maurits NM - PLoS ONE (2013)

Behavioral results comprised of mean RTs (bars) in milliseconds (ms) and accuracy scores (lines) in percentages (%) for young (black) and old (grey) adults.Behavioral outcomes are presented, separately, for the 0-back and the 1-back load in the identity version and in the integrated version.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3646823&req=5

pone-0063701-g002: Behavioral results comprised of mean RTs (bars) in milliseconds (ms) and accuracy scores (lines) in percentages (%) for young (black) and old (grey) adults.Behavioral outcomes are presented, separately, for the 0-back and the 1-back load in the identity version and in the integrated version.
Mentions: Mean accuracy scores and RTs for young and older adults, for the different task conditions are illustrated in Figure 2. The estimated proportion of correct responses was higher in the 0-back (92%) than in the 1-back load condition (90%; βintercept  = 2.33; z  = 34, p<0.0005; βload  = −.35; z  = −7.7, p<0.0001). However, this load effect was modulated by age and version (βage*load*version  = −.62; z  = −3.4, p<0.001). For older adults, the estimated proportion of correct responses was higher in the 0-back than in the 1-back load condition, in both versions (identity: 92.6% vs. 87.6%; βintercept identity version in the 0-back load  = 2.54 z  = 20.1, p<0.0001; β1-back  = −.55; z  = −6.14, p<0.0001 and integrated: 92.4% vs. 88.5%; βintercept integrated version in the 0-back load  = 2.49, z  = 17.91, p<0.0001; β1-back  = −46; z  = −5.25; p<0.0001). For young adults, this load effect was limited to the integrated version (93.6% vs. 90%; βintercept integrated version in the 0-back load  = 2.66, z  = 24.22, p<0.0001; β1-back  = −.47; z  = −4.98, p<0.0001).

Bottom Line: Among young adults, more efficient performance correlated with a larger P3 amplitude at parietal sites.In contrast, a higher P3 amplitude at midline electrode sites in older adults correlated with less efficient performance.Particularly, the enhanced frontal midline EEG activity in older adults during working memory performance seems to reflect inefficient use of neural resources due to frontal lobe dysfunction.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. e.saliasi@umcg.nl

ABSTRACT
While some elderly show deteriorations in cognitive performance, others achieve performance levels comparable to young adults. To examine whether age-related changes in brain activity varied with working memory performance efficiency, we recorded electroencephalography (EEG) from young and older healthy adults during performance on an n-back task with two loads (0- and 1-back) and two versions (identity and integrated). Young adults showed a typical P3 amplitude pattern with a parietal-maximum. Compared to young adults, the P3 amplitude of older adults was characterized by frontal hyperactivity coupled with posterior hypoactivity. Moreover, P3 amplitude in young and older adults varied with working memory performance efficiency. Among young adults, more efficient performance correlated with a larger P3 amplitude at parietal sites. In contrast, a higher P3 amplitude at midline electrode sites in older adults correlated with less efficient performance. Particularly, the enhanced frontal midline EEG activity in older adults during working memory performance seems to reflect inefficient use of neural resources due to frontal lobe dysfunction.

Show MeSH
Related in: MedlinePlus