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The relationship between P3 amplitude and working memory performance differs in young and older adults.

Saliasi E, Geerligs L, Lorist MM, Maurits NM - PLoS ONE (2013)

Bottom Line: Among young adults, more efficient performance correlated with a larger P3 amplitude at parietal sites.In contrast, a higher P3 amplitude at midline electrode sites in older adults correlated with less efficient performance.Particularly, the enhanced frontal midline EEG activity in older adults during working memory performance seems to reflect inefficient use of neural resources due to frontal lobe dysfunction.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. e.saliasi@umcg.nl

ABSTRACT
While some elderly show deteriorations in cognitive performance, others achieve performance levels comparable to young adults. To examine whether age-related changes in brain activity varied with working memory performance efficiency, we recorded electroencephalography (EEG) from young and older healthy adults during performance on an n-back task with two loads (0- and 1-back) and two versions (identity and integrated). Young adults showed a typical P3 amplitude pattern with a parietal-maximum. Compared to young adults, the P3 amplitude of older adults was characterized by frontal hyperactivity coupled with posterior hypoactivity. Moreover, P3 amplitude in young and older adults varied with working memory performance efficiency. Among young adults, more efficient performance correlated with a larger P3 amplitude at parietal sites. In contrast, a higher P3 amplitude at midline electrode sites in older adults correlated with less efficient performance. Particularly, the enhanced frontal midline EEG activity in older adults during working memory performance seems to reflect inefficient use of neural resources due to frontal lobe dysfunction.

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Schematic diagram of the n-back task, separately for each task load, and each task version.Details about timing for stimulus and inter trial interval (ITI) are included.
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pone-0063701-g001: Schematic diagram of the n-back task, separately for each task load, and each task version.Details about timing for stimulus and inter trial interval (ITI) are included.

Mentions: Working memory was tested using an adapted visual n-back task (Figure 1). Each block started with the presentation of the instructions, followed by a fixation cross, which was presented in the middle of the screen and remained visible throughout stimulus presentation. A continuous stream of letters was presented, one letter per frame, for 500 ms each. The time interval between two stimuli varied randomly between 1000 and 2000 ms. Each letter was randomly positioned in one of 8 possible locations (horizontalĂ—axis, vertical Y axis and the lower and upper position of both diagonals).


The relationship between P3 amplitude and working memory performance differs in young and older adults.

Saliasi E, Geerligs L, Lorist MM, Maurits NM - PLoS ONE (2013)

Schematic diagram of the n-back task, separately for each task load, and each task version.Details about timing for stimulus and inter trial interval (ITI) are included.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3646823&req=5

pone-0063701-g001: Schematic diagram of the n-back task, separately for each task load, and each task version.Details about timing for stimulus and inter trial interval (ITI) are included.
Mentions: Working memory was tested using an adapted visual n-back task (Figure 1). Each block started with the presentation of the instructions, followed by a fixation cross, which was presented in the middle of the screen and remained visible throughout stimulus presentation. A continuous stream of letters was presented, one letter per frame, for 500 ms each. The time interval between two stimuli varied randomly between 1000 and 2000 ms. Each letter was randomly positioned in one of 8 possible locations (horizontalĂ—axis, vertical Y axis and the lower and upper position of both diagonals).

Bottom Line: Among young adults, more efficient performance correlated with a larger P3 amplitude at parietal sites.In contrast, a higher P3 amplitude at midline electrode sites in older adults correlated with less efficient performance.Particularly, the enhanced frontal midline EEG activity in older adults during working memory performance seems to reflect inefficient use of neural resources due to frontal lobe dysfunction.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. e.saliasi@umcg.nl

ABSTRACT
While some elderly show deteriorations in cognitive performance, others achieve performance levels comparable to young adults. To examine whether age-related changes in brain activity varied with working memory performance efficiency, we recorded electroencephalography (EEG) from young and older healthy adults during performance on an n-back task with two loads (0- and 1-back) and two versions (identity and integrated). Young adults showed a typical P3 amplitude pattern with a parietal-maximum. Compared to young adults, the P3 amplitude of older adults was characterized by frontal hyperactivity coupled with posterior hypoactivity. Moreover, P3 amplitude in young and older adults varied with working memory performance efficiency. Among young adults, more efficient performance correlated with a larger P3 amplitude at parietal sites. In contrast, a higher P3 amplitude at midline electrode sites in older adults correlated with less efficient performance. Particularly, the enhanced frontal midline EEG activity in older adults during working memory performance seems to reflect inefficient use of neural resources due to frontal lobe dysfunction.

Show MeSH
Related in: MedlinePlus