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Obesity and Staphylococcus aureus nasal colonization among women and men in a general population.

Olsen K, Danielsen K, Wilsgaard T, Sangvik M, Sollid JU, Thune I, Eggen AE, Simonsen GS, Furberg AS - PLoS ONE (2013)

Bottom Line: Among men, high WC was also associated with S. aureus nasal colonization.The associations did not change significantly when the analysis was restricted to participants without signs of pre-diabetes (HbA1c <6.0%) among women and men, and to non-users of hormonal contraceptives among women.Our results support that obesity is a possible determinant for S. aureus nasal colonization independent of DM, in particular for premenopausal women.

View Article: PubMed Central - PubMed

Affiliation: Department of Microbiology and Infection Control, University Hospital of North Norway, Tromsø, Norway. karina.olsen@unn.no

ABSTRACT

Background: Obesity and diabetes mellitus (DM) have been linked to increased risk of infections, and Staphylococcus aureus nasal colonization is a major risk factor for developing infections with the microbe. We therefore sought to find whether body mass index (BMI) and waist circumference (WC) could be associated with S. aureus colonization independent of DM.

Methodology: S. aureus colonization was assessed by nasal swab cultures among 2,169 women and 1,709 men, aged 30-87 years, in the population-based Tromsø Staph and Skin Study in 2007-08. Height (cm), weight (kg), WC (cm), and glycated haemoglobin (HbA1c,%) were measured. Multivariable logistic regression analyses including information on DM, HbA1c, hormonal contraceptive use and other potential confounders were used.

Results: In the female population, each 2.5 kg/m(2) increase in BMI was associated with a 7% higher odds of S. aureus nasal colonization (P = 0.01). When comparing obese and lean women aged 30-43 years, we observed that BMI ≥32.5 versus <22.5 kg/m(2) and WC ≥101 versus <80 cm was associated with a 2.60 and 2.12 times higher odds of S. aureus colonization, respectively (95% confidence intervals 1.35-4.98 and 1.17-3.85). Among men, high WC was also associated with S. aureus nasal colonization. The associations did not change significantly when the analysis was restricted to participants without signs of pre-diabetes (HbA1c <6.0%) among women and men, and to non-users of hormonal contraceptives among women.

Conclusion: Our results support that obesity is a possible determinant for S. aureus nasal colonization independent of DM, in particular for premenopausal women. The role of obesity at different ages and by sex should be addressed in future prospective studies of S. aureus colonization.

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Related in: MedlinePlus

Probability of Staphylococcus aureus colonization.Probability of S. aureus carriage among women (n = 2,169) and men (n = 1,709) according to body mass index in kg/m2. Lines depict regression line (navy) with 95% mean prediction interval (grey area) from age-adjusted linear regression models.
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pone-0063716-g001: Probability of Staphylococcus aureus colonization.Probability of S. aureus carriage among women (n = 2,169) and men (n = 1,709) according to body mass index in kg/m2. Lines depict regression line (navy) with 95% mean prediction interval (grey area) from age-adjusted linear regression models.

Mentions: There was a positive relationship between BMI (continuous) and S. aureus nasal colonization among women (Figure 1, age-adjusted). For each 2.5 kg/m2 increase in BMI a 7% increase in the odds of S. aureus nasal colonization was observed (multivariable model; OR 1.07, 95% CI 1.01–1.14). The prevalence of S. aureus nasal colonization increased from 20.6% (95% CI 16.8–24.4) among women with BMI <22.5 kg/m2 to 28.1% (95% CI 22.2–34.0) among women with BMI ≥32.5 kg/m2, corresponding to a 67% increased odds (BMI ≥32.5 versus <22.5 kg/m2) (Table 2). In sensitivity analysis restricted to women with HbA1c <6.0%, the OR was attenuated to 1.07 for each 2.5 kg/m2 increase in BMI (95% CI 1.00–1.14, P = 0.06) and 1.56 for BMI ≥32.5 kg/m2 versus <22.5 kg/m2 (95% CI 0.99–2.46, P = 0.06). BMI was not associated with S. aureus nasal colonization among men.


Obesity and Staphylococcus aureus nasal colonization among women and men in a general population.

Olsen K, Danielsen K, Wilsgaard T, Sangvik M, Sollid JU, Thune I, Eggen AE, Simonsen GS, Furberg AS - PLoS ONE (2013)

Probability of Staphylococcus aureus colonization.Probability of S. aureus carriage among women (n = 2,169) and men (n = 1,709) according to body mass index in kg/m2. Lines depict regression line (navy) with 95% mean prediction interval (grey area) from age-adjusted linear regression models.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3646820&req=5

pone-0063716-g001: Probability of Staphylococcus aureus colonization.Probability of S. aureus carriage among women (n = 2,169) and men (n = 1,709) according to body mass index in kg/m2. Lines depict regression line (navy) with 95% mean prediction interval (grey area) from age-adjusted linear regression models.
Mentions: There was a positive relationship between BMI (continuous) and S. aureus nasal colonization among women (Figure 1, age-adjusted). For each 2.5 kg/m2 increase in BMI a 7% increase in the odds of S. aureus nasal colonization was observed (multivariable model; OR 1.07, 95% CI 1.01–1.14). The prevalence of S. aureus nasal colonization increased from 20.6% (95% CI 16.8–24.4) among women with BMI <22.5 kg/m2 to 28.1% (95% CI 22.2–34.0) among women with BMI ≥32.5 kg/m2, corresponding to a 67% increased odds (BMI ≥32.5 versus <22.5 kg/m2) (Table 2). In sensitivity analysis restricted to women with HbA1c <6.0%, the OR was attenuated to 1.07 for each 2.5 kg/m2 increase in BMI (95% CI 1.00–1.14, P = 0.06) and 1.56 for BMI ≥32.5 kg/m2 versus <22.5 kg/m2 (95% CI 0.99–2.46, P = 0.06). BMI was not associated with S. aureus nasal colonization among men.

Bottom Line: Among men, high WC was also associated with S. aureus nasal colonization.The associations did not change significantly when the analysis was restricted to participants without signs of pre-diabetes (HbA1c <6.0%) among women and men, and to non-users of hormonal contraceptives among women.Our results support that obesity is a possible determinant for S. aureus nasal colonization independent of DM, in particular for premenopausal women.

View Article: PubMed Central - PubMed

Affiliation: Department of Microbiology and Infection Control, University Hospital of North Norway, Tromsø, Norway. karina.olsen@unn.no

ABSTRACT

Background: Obesity and diabetes mellitus (DM) have been linked to increased risk of infections, and Staphylococcus aureus nasal colonization is a major risk factor for developing infections with the microbe. We therefore sought to find whether body mass index (BMI) and waist circumference (WC) could be associated with S. aureus colonization independent of DM.

Methodology: S. aureus colonization was assessed by nasal swab cultures among 2,169 women and 1,709 men, aged 30-87 years, in the population-based Tromsø Staph and Skin Study in 2007-08. Height (cm), weight (kg), WC (cm), and glycated haemoglobin (HbA1c,%) were measured. Multivariable logistic regression analyses including information on DM, HbA1c, hormonal contraceptive use and other potential confounders were used.

Results: In the female population, each 2.5 kg/m(2) increase in BMI was associated with a 7% higher odds of S. aureus nasal colonization (P = 0.01). When comparing obese and lean women aged 30-43 years, we observed that BMI ≥32.5 versus <22.5 kg/m(2) and WC ≥101 versus <80 cm was associated with a 2.60 and 2.12 times higher odds of S. aureus colonization, respectively (95% confidence intervals 1.35-4.98 and 1.17-3.85). Among men, high WC was also associated with S. aureus nasal colonization. The associations did not change significantly when the analysis was restricted to participants without signs of pre-diabetes (HbA1c <6.0%) among women and men, and to non-users of hormonal contraceptives among women.

Conclusion: Our results support that obesity is a possible determinant for S. aureus nasal colonization independent of DM, in particular for premenopausal women. The role of obesity at different ages and by sex should be addressed in future prospective studies of S. aureus colonization.

Show MeSH
Related in: MedlinePlus