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Utilizing harmonization and common surveillance methods to consolidate 4 cohorts: the Western Alaska Tribal Collaborative for Health (WATCH) study.

Koller KR, Wolfe AW, Metzger JS, Austin MA, Hopkins SE, Kaufmann C, Jolly SE, Ebbesson SO, Umans JG, Howard BV, Boyer BB - Int J Circumpolar Health (2013)

Bottom Line: Prospective surveillance data over an average 6.7-year follow-up can now be used to study CVD and diabetes incidence and associated risk factors in a subset of 2,754 western AN participants (1,218 men and 1,536 women) who consented to initial surveillance.The combined cohort provides statistical power to examine incidence rates and risk factors for CVD and diabetes and allows for analyses by geographic region.The data can be used to develop intervention programmes in these populations and others.

View Article: PubMed Central - PubMed

Affiliation: Division of Community Health Services, Alaska Native Tribal Health Consortium, Anchorage, AK, USA.

ABSTRACT

Background: According to health status reports, chronic disease prevalence appears to be rising in western Alaska Native (AN) people, and accurate population-based data are needed. Four cohort studies of western AN people were conducted in the Norton Sound and Yukon-Kuskokwim regions, but none have been large enough to allow reliable estimates of rates of chronic diseases and evaluate their risk factors.

Objective: In this article, the methods used to combine 4 major cohort studies of rural western AN people are described and the benefits and challenges encountered in combining data and standardizing surveillance methods for these studies are discussed.

Design: Tribal permission was obtained for each cohort study and the consolidated study. Data from baseline exams were directly combined or harmonized into new variables. Common surveillance methods were developed and implemented to identify incidence and risk factors for cardiovascular disease (CVD) events and type 2 diabetes.

Results: A cohort of 4,569 western AN participants (2,116 men and 2,453 women), aged 18-95 years, was established to study CVD and diabetes prevalence. Prospective surveillance data over an average 6.7-year follow-up can now be used to study CVD and diabetes incidence and associated risk factors in a subset of 2,754 western AN participants (1,218 men and 1,536 women) who consented to initial surveillance.

Conclusions: The combined cohort provides statistical power to examine incidence rates and risk factors for CVD and diabetes and allows for analyses by geographic region. The data can be used to develop intervention programmes in these populations and others.

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Related in: MedlinePlus

WATCH study data consolidation flow.
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Figure 0001: WATCH study data consolidation flow.

Mentions: The WATCH data consolidation flow for both the prevalence and surveillance phases is shown in Fig. 1. For each original study, participants were assigned a study identifier (ID) and each study retained its own study ID key. Data managers ensured no cases were duplicated between studies (i.e. all cases were unique and were not included in more than 1 study). To maintain confidentiality, the operations committee replaced all originally assigned WATCH IDs with a second unique ID and retained the only key to the second set of WATCH IDs. For all medical record reviews, records were deidentified and a WATCH study ID was used.


Utilizing harmonization and common surveillance methods to consolidate 4 cohorts: the Western Alaska Tribal Collaborative for Health (WATCH) study.

Koller KR, Wolfe AW, Metzger JS, Austin MA, Hopkins SE, Kaufmann C, Jolly SE, Ebbesson SO, Umans JG, Howard BV, Boyer BB - Int J Circumpolar Health (2013)

WATCH study data consolidation flow.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3644062&req=5

Figure 0001: WATCH study data consolidation flow.
Mentions: The WATCH data consolidation flow for both the prevalence and surveillance phases is shown in Fig. 1. For each original study, participants were assigned a study identifier (ID) and each study retained its own study ID key. Data managers ensured no cases were duplicated between studies (i.e. all cases were unique and were not included in more than 1 study). To maintain confidentiality, the operations committee replaced all originally assigned WATCH IDs with a second unique ID and retained the only key to the second set of WATCH IDs. For all medical record reviews, records were deidentified and a WATCH study ID was used.

Bottom Line: Prospective surveillance data over an average 6.7-year follow-up can now be used to study CVD and diabetes incidence and associated risk factors in a subset of 2,754 western AN participants (1,218 men and 1,536 women) who consented to initial surveillance.The combined cohort provides statistical power to examine incidence rates and risk factors for CVD and diabetes and allows for analyses by geographic region.The data can be used to develop intervention programmes in these populations and others.

View Article: PubMed Central - PubMed

Affiliation: Division of Community Health Services, Alaska Native Tribal Health Consortium, Anchorage, AK, USA.

ABSTRACT

Background: According to health status reports, chronic disease prevalence appears to be rising in western Alaska Native (AN) people, and accurate population-based data are needed. Four cohort studies of western AN people were conducted in the Norton Sound and Yukon-Kuskokwim regions, but none have been large enough to allow reliable estimates of rates of chronic diseases and evaluate their risk factors.

Objective: In this article, the methods used to combine 4 major cohort studies of rural western AN people are described and the benefits and challenges encountered in combining data and standardizing surveillance methods for these studies are discussed.

Design: Tribal permission was obtained for each cohort study and the consolidated study. Data from baseline exams were directly combined or harmonized into new variables. Common surveillance methods were developed and implemented to identify incidence and risk factors for cardiovascular disease (CVD) events and type 2 diabetes.

Results: A cohort of 4,569 western AN participants (2,116 men and 2,453 women), aged 18-95 years, was established to study CVD and diabetes prevalence. Prospective surveillance data over an average 6.7-year follow-up can now be used to study CVD and diabetes incidence and associated risk factors in a subset of 2,754 western AN participants (1,218 men and 1,536 women) who consented to initial surveillance.

Conclusions: The combined cohort provides statistical power to examine incidence rates and risk factors for CVD and diabetes and allows for analyses by geographic region. The data can be used to develop intervention programmes in these populations and others.

Show MeSH
Related in: MedlinePlus