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A comparison of the clinical and epidemiological characteristics of adult patients with laboratory-confirmed influenza A or B during the 2011-2012 influenza season in Korea: a multi-center study.

Wie SH, So BH, Song JY, Cheong HJ, Seo YB, Choi SH, Noh JY, Baek JH, Lee JS, Kim HY, Kim YK, Choi WS, Lee J, Jeong HW, Kim WJ - PLoS ONE (2013)

Bottom Line: We analyzed data from 2,129 adult patients with influenza-like illnesses who visited the emergency rooms of seven university hospitals in Korea from October 2011 to May 2012.The proportion of males to females and elderly population were significantly higher for influenza A (H3N2) patients group compared with influenza B group.Hypertension, diabetes, chronic lung diseases, cardiovascular disorders, and neuromuscular diseases were independently associated with hospitalization due to influenza.

View Article: PubMed Central - PubMed

Affiliation: Division of Infectious Diseases, Department of Internal Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

ABSTRACT

Background: During the 2011/2012 winter influenza season in the Republic of Korea, influenza A (H3N2) was the predominant virus in the first peak period of influenza activity during the second half of January 2012. On the other hand, influenza B was the predominant virus in the second peak period of influenza activity during the second half of March 2012. The objectives of this study were to compare the clinical and epidemiological characteristics of patients with laboratory-confirmed influenza A or influenza B.

Methodology/principal findings: We analyzed data from 2,129 adult patients with influenza-like illnesses who visited the emergency rooms of seven university hospitals in Korea from October 2011 to May 2012. Of 850 patients with laboratory-confirmed influenza, 656 (77.2%) had influenza A (H3N2), and 194 (22.8%) influenza B. Age, and the frequencies of cardiovascular disorders, diabetes, hypertension were significantly higher in patients with influenza A (H3N2) (P<0.05). The frequencies of leukopenia or thrombocytopenia in patients with influenza B at initial presentation were statistically higher than those in patients with influenza A (H3N2) (P<0.05). The rate of hospitalization, and length of hospital stay were statistically higher in patients with influenza A (H3N2) (P<0.05), and of the 79 hospitalized patients, the frequency of diabetes, hypertension, cases having at least one of the comorbid conditions, and the proportion of elderly were significantly higher in patients with influenza A (H3N2) (P<0.05).

Conclusions: The proportion of males to females and elderly population were significantly higher for influenza A (H3N2) patients group compared with influenza B group. Hypertension, diabetes, chronic lung diseases, cardiovascular disorders, and neuromuscular diseases were independently associated with hospitalization due to influenza. Physicians should assess and treat the underlying comorbid conditions as well as influenza viral infections for the appropriate management of patients with influenza.

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Weekly number of adult patients with laboratory-confirmed influenza A and B, 2011–2012.
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pone-0062685-g002: Weekly number of adult patients with laboratory-confirmed influenza A and B, 2011–2012.

Mentions: A total of 2,129 patients with ILI who visited the emergency rooms of seven university hospitals in Korea from October 2011 to May 2012 were screened. Of these patients, 656 cases of laboratory-confirmed influenza A (H3N2) and 194 cases of laboratory-confirmed influenza B were enrolled and prospectively compared for clinical features, laboratory parameters, complications, and clinical outcomes (Figure 1). During the weeks 41- and 42 (Oct 2∼Oct 15), two female patients were diagnosed with laboratory-confirmed influenza A (H3N2), and then laboratory-confirmed influenza A (H3N2) began to be seen again in week 52 (Dec 18∼Dec 24) and peaked in week 3 (Jan 15∼Jan 21) in the 2011–2012 influenza season. Laboratory-confirmed influenza B began to be seen in week 1 (Jan 1∼Jan 7) and peaked in week 13 (Mar 25∼Mar 31) in the 2011–2012 influenza season, and the number of patients with laboratory-confirmed influenza B was higher than the number of those with laboratory-confirmed influenza A (H3N2) during weeks 12–18 (Mar 18∼May 5) (Figure 2).


A comparison of the clinical and epidemiological characteristics of adult patients with laboratory-confirmed influenza A or B during the 2011-2012 influenza season in Korea: a multi-center study.

Wie SH, So BH, Song JY, Cheong HJ, Seo YB, Choi SH, Noh JY, Baek JH, Lee JS, Kim HY, Kim YK, Choi WS, Lee J, Jeong HW, Kim WJ - PLoS ONE (2013)

Weekly number of adult patients with laboratory-confirmed influenza A and B, 2011–2012.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3643978&req=5

pone-0062685-g002: Weekly number of adult patients with laboratory-confirmed influenza A and B, 2011–2012.
Mentions: A total of 2,129 patients with ILI who visited the emergency rooms of seven university hospitals in Korea from October 2011 to May 2012 were screened. Of these patients, 656 cases of laboratory-confirmed influenza A (H3N2) and 194 cases of laboratory-confirmed influenza B were enrolled and prospectively compared for clinical features, laboratory parameters, complications, and clinical outcomes (Figure 1). During the weeks 41- and 42 (Oct 2∼Oct 15), two female patients were diagnosed with laboratory-confirmed influenza A (H3N2), and then laboratory-confirmed influenza A (H3N2) began to be seen again in week 52 (Dec 18∼Dec 24) and peaked in week 3 (Jan 15∼Jan 21) in the 2011–2012 influenza season. Laboratory-confirmed influenza B began to be seen in week 1 (Jan 1∼Jan 7) and peaked in week 13 (Mar 25∼Mar 31) in the 2011–2012 influenza season, and the number of patients with laboratory-confirmed influenza B was higher than the number of those with laboratory-confirmed influenza A (H3N2) during weeks 12–18 (Mar 18∼May 5) (Figure 2).

Bottom Line: We analyzed data from 2,129 adult patients with influenza-like illnesses who visited the emergency rooms of seven university hospitals in Korea from October 2011 to May 2012.The proportion of males to females and elderly population were significantly higher for influenza A (H3N2) patients group compared with influenza B group.Hypertension, diabetes, chronic lung diseases, cardiovascular disorders, and neuromuscular diseases were independently associated with hospitalization due to influenza.

View Article: PubMed Central - PubMed

Affiliation: Division of Infectious Diseases, Department of Internal Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

ABSTRACT

Background: During the 2011/2012 winter influenza season in the Republic of Korea, influenza A (H3N2) was the predominant virus in the first peak period of influenza activity during the second half of January 2012. On the other hand, influenza B was the predominant virus in the second peak period of influenza activity during the second half of March 2012. The objectives of this study were to compare the clinical and epidemiological characteristics of patients with laboratory-confirmed influenza A or influenza B.

Methodology/principal findings: We analyzed data from 2,129 adult patients with influenza-like illnesses who visited the emergency rooms of seven university hospitals in Korea from October 2011 to May 2012. Of 850 patients with laboratory-confirmed influenza, 656 (77.2%) had influenza A (H3N2), and 194 (22.8%) influenza B. Age, and the frequencies of cardiovascular disorders, diabetes, hypertension were significantly higher in patients with influenza A (H3N2) (P<0.05). The frequencies of leukopenia or thrombocytopenia in patients with influenza B at initial presentation were statistically higher than those in patients with influenza A (H3N2) (P<0.05). The rate of hospitalization, and length of hospital stay were statistically higher in patients with influenza A (H3N2) (P<0.05), and of the 79 hospitalized patients, the frequency of diabetes, hypertension, cases having at least one of the comorbid conditions, and the proportion of elderly were significantly higher in patients with influenza A (H3N2) (P<0.05).

Conclusions: The proportion of males to females and elderly population were significantly higher for influenza A (H3N2) patients group compared with influenza B group. Hypertension, diabetes, chronic lung diseases, cardiovascular disorders, and neuromuscular diseases were independently associated with hospitalization due to influenza. Physicians should assess and treat the underlying comorbid conditions as well as influenza viral infections for the appropriate management of patients with influenza.

Show MeSH
Related in: MedlinePlus