Limits...
The absence of obstructive sleep apnea may protect against non-alcoholic fatty liver in patients undergoing bariatric surgery.

Corey KE, Misdraji J, Zheng H, Malecki KM, Kneeman J, Gelrud L, Chung RT - PLoS ONE (2013)

Bottom Line: Patients with other causes of chronic liver disease were excluded.One hundred fifty-nine patients were included.Our study confirmed several factors associated with normal liver histology, including black race and identified a novel factor, absence of OSA.

View Article: PubMed Central - PubMed

Affiliation: Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America.

ABSTRACT

Background: Non-alcoholic fatty liver disease (NAFLD) is the most common cause of liver disease worldwide and its progressive form, steatohepatitis, will be the leading indication for liver transplant by 2020. While risk factors for steatohepatitis have been identified, little work has been performed to identify factors protective against NAFLD development.

Aim: This study sought to identify factors predictive of normal liver histology in a bariatric cohort.

Methods: Patients undergoing weight loss surgery with liver biopsies at the time of surgery were included. Patients with other causes of chronic liver disease were excluded.

Results: One hundred fifty-nine patients were included. Forty-nine patients had normal liver histology and 110 patients had NAFLD. Several previously identified factors associated with normal liver histology were found. Black race was the strongest predictor of the absence of NAFLD with an odds ratio (OR) of 6.8, 95% confidence interval (CI) 2.4-18.9. Low HOMA-IR was also associated with normal histology (OR 1.4, 95% CI 1.03-1.9). In contrast, low HDL was associated with a decreased chance of normal histology (OR 0.38, 95% CI 0.05-0.83). Interestingly, a novel protective factor, the absence of obstructive sleep apnea (OSA) was strongly associated with normal histology (OR 5.6, 95% CI 2.0-16.1). In multivariate regression controlling for BMI, black race, absence of OSA, low HOMA-IR and low ALT independently predicted normal liver histology with an area under the ROC curve of 0.85.

Conclusions: Our study confirmed several factors associated with normal liver histology, including black race and identified a novel factor, absence of OSA. Further evaluation of these factors will allow for improved understanding of the pathogenesis of NAFLD.

Show MeSH

Related in: MedlinePlus

This figure graphically displays the range of the scores for the Healthy Liver Score and the corresponding liver histology.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3643948&req=5

pone-0062504-g001: This figure graphically displays the range of the scores for the Healthy Liver Score and the corresponding liver histology.

Mentions: The presence of obstructive sleep apnea is coded as 1 and the absence as value of 0. Black race receives a value of 1 and white patients receive a value of 0. The Healthy Liver Score values range from −12 to 3 in our cohort. (Figure 1).


The absence of obstructive sleep apnea may protect against non-alcoholic fatty liver in patients undergoing bariatric surgery.

Corey KE, Misdraji J, Zheng H, Malecki KM, Kneeman J, Gelrud L, Chung RT - PLoS ONE (2013)

This figure graphically displays the range of the scores for the Healthy Liver Score and the corresponding liver histology.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3643948&req=5

pone-0062504-g001: This figure graphically displays the range of the scores for the Healthy Liver Score and the corresponding liver histology.
Mentions: The presence of obstructive sleep apnea is coded as 1 and the absence as value of 0. Black race receives a value of 1 and white patients receive a value of 0. The Healthy Liver Score values range from −12 to 3 in our cohort. (Figure 1).

Bottom Line: Patients with other causes of chronic liver disease were excluded.One hundred fifty-nine patients were included.Our study confirmed several factors associated with normal liver histology, including black race and identified a novel factor, absence of OSA.

View Article: PubMed Central - PubMed

Affiliation: Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America.

ABSTRACT

Background: Non-alcoholic fatty liver disease (NAFLD) is the most common cause of liver disease worldwide and its progressive form, steatohepatitis, will be the leading indication for liver transplant by 2020. While risk factors for steatohepatitis have been identified, little work has been performed to identify factors protective against NAFLD development.

Aim: This study sought to identify factors predictive of normal liver histology in a bariatric cohort.

Methods: Patients undergoing weight loss surgery with liver biopsies at the time of surgery were included. Patients with other causes of chronic liver disease were excluded.

Results: One hundred fifty-nine patients were included. Forty-nine patients had normal liver histology and 110 patients had NAFLD. Several previously identified factors associated with normal liver histology were found. Black race was the strongest predictor of the absence of NAFLD with an odds ratio (OR) of 6.8, 95% confidence interval (CI) 2.4-18.9. Low HOMA-IR was also associated with normal histology (OR 1.4, 95% CI 1.03-1.9). In contrast, low HDL was associated with a decreased chance of normal histology (OR 0.38, 95% CI 0.05-0.83). Interestingly, a novel protective factor, the absence of obstructive sleep apnea (OSA) was strongly associated with normal histology (OR 5.6, 95% CI 2.0-16.1). In multivariate regression controlling for BMI, black race, absence of OSA, low HOMA-IR and low ALT independently predicted normal liver histology with an area under the ROC curve of 0.85.

Conclusions: Our study confirmed several factors associated with normal liver histology, including black race and identified a novel factor, absence of OSA. Further evaluation of these factors will allow for improved understanding of the pathogenesis of NAFLD.

Show MeSH
Related in: MedlinePlus