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Total and carboxylated osteocalcin associate with insulin levels in young adults born with normal or very low birth weight.

Paldánius PM, Ivaska KK, Hovi P, Andersson S, Eriksson JG, Väänänen K, Kajantie E, Mäkitie O - PLoS ONE (2013)

Bottom Line: OGTT induced a significant reduction in OC (p<0.001), similar in both groups.OC reduction was not associated with OGTT-induced increases in insulin (p = 0.54).Serum OC appears to be negatively associated with long-term glucose regulation whereas acute changes during OGTT may be mediated via other mechanisms.

View Article: PubMed Central - PubMed

Affiliation: Children's Hospital, Helsinki University Central Hospital, and Institute of Clinical Medicine, University of Helsinki, Helsinki, Finland. ppaldanius@gmail.com

ABSTRACT

Objective: Osteocalcin (OC), a bone-derived protein, has been implicated in the regulation of glucose and energy metabolism. Young adults born with very low birth weight (VLBW) have altered glucose regulation and lower bone mineral density (BMD) compared with those born at term. The aim of this study was to explore the association between bone and glucose metabolism in healthy young adults born prematurely or at term.

Methods: The cohort of this cross-sectional study comprised 332 non-diabetic young adults (age 18 to 27 years) born either preterm with VLBW (n = 163) or at term (n = 169). OC, carboxylated osteocalcin (cOC) and markers of glucose metabolism were measured at fasting and after a 75-g oral glucose tolerance test (OGTT).

Results: VLBW adults were shorter, had lower BMD (p<0.001) and higher fasting OC (p = 0.027) and cOC (p = 0.005) than term-born subjects. They also had higher 2-hour insulin (p = 0.001) and glucose (p = 0.037) concentrations. OGTT induced a significant reduction in OC (p<0.001), similar in both groups. OC reduction was not associated with OGTT-induced increases in insulin (p = 0.54). However, fasting total OC and cOC correlated negatively with fasting insulin after adjustment for age, gender, BMD and VLBW status (r = -0.182, p = 0.009 and r = -0.283, p<0.001, respectively).

Conclusion: Adults born with VLBW have higher OC and cOC than their peers born at term. This may in part reflect the mechanisms that underlie their lower BMD and decreased insulin sensitivity. Serum OC appears to be negatively associated with long-term glucose regulation whereas acute changes during OGTT may be mediated via other mechanisms.

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Related in: MedlinePlus

Standardized linear regression coefficients (βstd) between fasting insulin and A) total osteocalcin or B) carboxylated osteocalcin.Results are shown separately for the entire cohort (All) and the two groups (Term, VLBW) and they have been adjusted for age, gender and Z-score for lumbar spine BMD. Squares indicate the value for βstd, and the whiskers represent 95% confidence interval. The P values are indicated with asterisks: *, P<0.05; **, P<0.01; ***, P<0.001; ns, not significant.
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pone-0063036-g002: Standardized linear regression coefficients (βstd) between fasting insulin and A) total osteocalcin or B) carboxylated osteocalcin.Results are shown separately for the entire cohort (All) and the two groups (Term, VLBW) and they have been adjusted for age, gender and Z-score for lumbar spine BMD. Squares indicate the value for βstd, and the whiskers represent 95% confidence interval. The P values are indicated with asterisks: *, P<0.05; **, P<0.01; ***, P<0.001; ns, not significant.

Mentions: Fasting total OC and cOC were negatively correlated with fasting insulin levels after adjustment for age, gender, VLBW status and BMD (r = −0.182, p = 0.009 and r = −0.283, p<0.001, respectively) (Table 3). The correlation between fasting insulin and cOC remained significant also after adjustment for lean body mass (r = −0.242, p<0.001) and whole body fat percent (r = −0.144, p = 0.028) (Table 3). The correlation between insulin and OC was similar in both groups, although the r -values were generally larger in the VLBW group (Figure 2). There was no significant association between insulin and total OC when the correlations were further adjusted for body fat percentage. As expected, total OC and lumbar spine Z-score were inversely correlated in all subjects (βstd = −0.239, p<0.001) independent of gender or VLBW status.


Total and carboxylated osteocalcin associate with insulin levels in young adults born with normal or very low birth weight.

Paldánius PM, Ivaska KK, Hovi P, Andersson S, Eriksson JG, Väänänen K, Kajantie E, Mäkitie O - PLoS ONE (2013)

Standardized linear regression coefficients (βstd) between fasting insulin and A) total osteocalcin or B) carboxylated osteocalcin.Results are shown separately for the entire cohort (All) and the two groups (Term, VLBW) and they have been adjusted for age, gender and Z-score for lumbar spine BMD. Squares indicate the value for βstd, and the whiskers represent 95% confidence interval. The P values are indicated with asterisks: *, P<0.05; **, P<0.01; ***, P<0.001; ns, not significant.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3643916&req=5

pone-0063036-g002: Standardized linear regression coefficients (βstd) between fasting insulin and A) total osteocalcin or B) carboxylated osteocalcin.Results are shown separately for the entire cohort (All) and the two groups (Term, VLBW) and they have been adjusted for age, gender and Z-score for lumbar spine BMD. Squares indicate the value for βstd, and the whiskers represent 95% confidence interval. The P values are indicated with asterisks: *, P<0.05; **, P<0.01; ***, P<0.001; ns, not significant.
Mentions: Fasting total OC and cOC were negatively correlated with fasting insulin levels after adjustment for age, gender, VLBW status and BMD (r = −0.182, p = 0.009 and r = −0.283, p<0.001, respectively) (Table 3). The correlation between fasting insulin and cOC remained significant also after adjustment for lean body mass (r = −0.242, p<0.001) and whole body fat percent (r = −0.144, p = 0.028) (Table 3). The correlation between insulin and OC was similar in both groups, although the r -values were generally larger in the VLBW group (Figure 2). There was no significant association between insulin and total OC when the correlations were further adjusted for body fat percentage. As expected, total OC and lumbar spine Z-score were inversely correlated in all subjects (βstd = −0.239, p<0.001) independent of gender or VLBW status.

Bottom Line: OGTT induced a significant reduction in OC (p<0.001), similar in both groups.OC reduction was not associated with OGTT-induced increases in insulin (p = 0.54).Serum OC appears to be negatively associated with long-term glucose regulation whereas acute changes during OGTT may be mediated via other mechanisms.

View Article: PubMed Central - PubMed

Affiliation: Children's Hospital, Helsinki University Central Hospital, and Institute of Clinical Medicine, University of Helsinki, Helsinki, Finland. ppaldanius@gmail.com

ABSTRACT

Objective: Osteocalcin (OC), a bone-derived protein, has been implicated in the regulation of glucose and energy metabolism. Young adults born with very low birth weight (VLBW) have altered glucose regulation and lower bone mineral density (BMD) compared with those born at term. The aim of this study was to explore the association between bone and glucose metabolism in healthy young adults born prematurely or at term.

Methods: The cohort of this cross-sectional study comprised 332 non-diabetic young adults (age 18 to 27 years) born either preterm with VLBW (n = 163) or at term (n = 169). OC, carboxylated osteocalcin (cOC) and markers of glucose metabolism were measured at fasting and after a 75-g oral glucose tolerance test (OGTT).

Results: VLBW adults were shorter, had lower BMD (p<0.001) and higher fasting OC (p = 0.027) and cOC (p = 0.005) than term-born subjects. They also had higher 2-hour insulin (p = 0.001) and glucose (p = 0.037) concentrations. OGTT induced a significant reduction in OC (p<0.001), similar in both groups. OC reduction was not associated with OGTT-induced increases in insulin (p = 0.54). However, fasting total OC and cOC correlated negatively with fasting insulin after adjustment for age, gender, BMD and VLBW status (r = -0.182, p = 0.009 and r = -0.283, p<0.001, respectively).

Conclusion: Adults born with VLBW have higher OC and cOC than their peers born at term. This may in part reflect the mechanisms that underlie their lower BMD and decreased insulin sensitivity. Serum OC appears to be negatively associated with long-term glucose regulation whereas acute changes during OGTT may be mediated via other mechanisms.

Show MeSH
Related in: MedlinePlus