Limits...
Total and carboxylated osteocalcin associate with insulin levels in young adults born with normal or very low birth weight.

Paldánius PM, Ivaska KK, Hovi P, Andersson S, Eriksson JG, Väänänen K, Kajantie E, Mäkitie O - PLoS ONE (2013)

Bottom Line: OGTT induced a significant reduction in OC (p<0.001), similar in both groups.OC reduction was not associated with OGTT-induced increases in insulin (p = 0.54).Serum OC appears to be negatively associated with long-term glucose regulation whereas acute changes during OGTT may be mediated via other mechanisms.

View Article: PubMed Central - PubMed

Affiliation: Children's Hospital, Helsinki University Central Hospital, and Institute of Clinical Medicine, University of Helsinki, Helsinki, Finland. ppaldanius@gmail.com

ABSTRACT

Objective: Osteocalcin (OC), a bone-derived protein, has been implicated in the regulation of glucose and energy metabolism. Young adults born with very low birth weight (VLBW) have altered glucose regulation and lower bone mineral density (BMD) compared with those born at term. The aim of this study was to explore the association between bone and glucose metabolism in healthy young adults born prematurely or at term.

Methods: The cohort of this cross-sectional study comprised 332 non-diabetic young adults (age 18 to 27 years) born either preterm with VLBW (n = 163) or at term (n = 169). OC, carboxylated osteocalcin (cOC) and markers of glucose metabolism were measured at fasting and after a 75-g oral glucose tolerance test (OGTT).

Results: VLBW adults were shorter, had lower BMD (p<0.001) and higher fasting OC (p = 0.027) and cOC (p = 0.005) than term-born subjects. They also had higher 2-hour insulin (p = 0.001) and glucose (p = 0.037) concentrations. OGTT induced a significant reduction in OC (p<0.001), similar in both groups. OC reduction was not associated with OGTT-induced increases in insulin (p = 0.54). However, fasting total OC and cOC correlated negatively with fasting insulin after adjustment for age, gender, BMD and VLBW status (r = -0.182, p = 0.009 and r = -0.283, p<0.001, respectively).

Conclusion: Adults born with VLBW have higher OC and cOC than their peers born at term. This may in part reflect the mechanisms that underlie their lower BMD and decreased insulin sensitivity. Serum OC appears to be negatively associated with long-term glucose regulation whereas acute changes during OGTT may be mediated via other mechanisms.

Show MeSH

Related in: MedlinePlus

Glucose (A), insulin (B), total osteocalcin (C) and carboxylated osteocalcin (D) before and after 2-hour oral glucose tolerance test in term and VLBW subjects.The lines inside the boxes represent the 50th percentile; the limits of the boxes represent the 25th and 75th percentiles, and the whiskers represent the 10th and 90th percentiles.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3643916&req=5

pone-0063036-g001: Glucose (A), insulin (B), total osteocalcin (C) and carboxylated osteocalcin (D) before and after 2-hour oral glucose tolerance test in term and VLBW subjects.The lines inside the boxes represent the 50th percentile; the limits of the boxes represent the 25th and 75th percentiles, and the whiskers represent the 10th and 90th percentiles.

Mentions: Subjects with VLBW had higher fasting levels of OC (ANOVA, p = 0.027) and cOC (p = 0.005) than the term-born subjects. Total OC and cOC remained higher also after OGTT in VLBW subjects as compared with those born at term (ANOVA, p = 0.016 and p = 0.007, respectively) (Table 2, Figure 1). Male subjects had significantly higher levels of total OC and cOC than female subjects, both in the VLBW group and in subjects born at term (p<0.001 for all). The difference between subjects with VLBW and those born at term tended to be more pronounced in females but the difference did not reach statistical significance. The mean lumbar spine Z score values were significantly lower in VLBW subjects (−0.94) than in those born at term (−0.42, p<0.001).


Total and carboxylated osteocalcin associate with insulin levels in young adults born with normal or very low birth weight.

Paldánius PM, Ivaska KK, Hovi P, Andersson S, Eriksson JG, Väänänen K, Kajantie E, Mäkitie O - PLoS ONE (2013)

Glucose (A), insulin (B), total osteocalcin (C) and carboxylated osteocalcin (D) before and after 2-hour oral glucose tolerance test in term and VLBW subjects.The lines inside the boxes represent the 50th percentile; the limits of the boxes represent the 25th and 75th percentiles, and the whiskers represent the 10th and 90th percentiles.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3643916&req=5

pone-0063036-g001: Glucose (A), insulin (B), total osteocalcin (C) and carboxylated osteocalcin (D) before and after 2-hour oral glucose tolerance test in term and VLBW subjects.The lines inside the boxes represent the 50th percentile; the limits of the boxes represent the 25th and 75th percentiles, and the whiskers represent the 10th and 90th percentiles.
Mentions: Subjects with VLBW had higher fasting levels of OC (ANOVA, p = 0.027) and cOC (p = 0.005) than the term-born subjects. Total OC and cOC remained higher also after OGTT in VLBW subjects as compared with those born at term (ANOVA, p = 0.016 and p = 0.007, respectively) (Table 2, Figure 1). Male subjects had significantly higher levels of total OC and cOC than female subjects, both in the VLBW group and in subjects born at term (p<0.001 for all). The difference between subjects with VLBW and those born at term tended to be more pronounced in females but the difference did not reach statistical significance. The mean lumbar spine Z score values were significantly lower in VLBW subjects (−0.94) than in those born at term (−0.42, p<0.001).

Bottom Line: OGTT induced a significant reduction in OC (p<0.001), similar in both groups.OC reduction was not associated with OGTT-induced increases in insulin (p = 0.54).Serum OC appears to be negatively associated with long-term glucose regulation whereas acute changes during OGTT may be mediated via other mechanisms.

View Article: PubMed Central - PubMed

Affiliation: Children's Hospital, Helsinki University Central Hospital, and Institute of Clinical Medicine, University of Helsinki, Helsinki, Finland. ppaldanius@gmail.com

ABSTRACT

Objective: Osteocalcin (OC), a bone-derived protein, has been implicated in the regulation of glucose and energy metabolism. Young adults born with very low birth weight (VLBW) have altered glucose regulation and lower bone mineral density (BMD) compared with those born at term. The aim of this study was to explore the association between bone and glucose metabolism in healthy young adults born prematurely or at term.

Methods: The cohort of this cross-sectional study comprised 332 non-diabetic young adults (age 18 to 27 years) born either preterm with VLBW (n = 163) or at term (n = 169). OC, carboxylated osteocalcin (cOC) and markers of glucose metabolism were measured at fasting and after a 75-g oral glucose tolerance test (OGTT).

Results: VLBW adults were shorter, had lower BMD (p<0.001) and higher fasting OC (p = 0.027) and cOC (p = 0.005) than term-born subjects. They also had higher 2-hour insulin (p = 0.001) and glucose (p = 0.037) concentrations. OGTT induced a significant reduction in OC (p<0.001), similar in both groups. OC reduction was not associated with OGTT-induced increases in insulin (p = 0.54). However, fasting total OC and cOC correlated negatively with fasting insulin after adjustment for age, gender, BMD and VLBW status (r = -0.182, p = 0.009 and r = -0.283, p<0.001, respectively).

Conclusion: Adults born with VLBW have higher OC and cOC than their peers born at term. This may in part reflect the mechanisms that underlie their lower BMD and decreased insulin sensitivity. Serum OC appears to be negatively associated with long-term glucose regulation whereas acute changes during OGTT may be mediated via other mechanisms.

Show MeSH
Related in: MedlinePlus