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Cell-type specificity of lung cancer associated with low-dose soil heavy metal contamination in Taiwan: an ecological study.

Huang HH, Huang JY, Lung CC, Wu CL, Ho CC, Sun YH, Ko PC, Su SY, Chen SC, Liaw YP - BMC Public Health (2013)

Bottom Line: For males, the trend test for lung SCC incidence caused by exposure to Cr, Cu, Hg, Ni, and Zn showed a statistically significant dose-response relationship.However, for lung AC, only Cu and Ni had a significant dose-response relationship.As for females, those achieving a statistically significant dose-response relationship for the trend test were Cr (P = 0.02), Ni (P = 0.02), and Zn (P= 0.02) for lung SCC, and Cu (P < 0.01) and Zn (P = 0.02) for lung AC.

View Article: PubMed Central - HTML - PubMed

Affiliation: Jen-Ai Hospital, Taichung City 41265, Taiwan.

ABSTRACT

Background: Numerous studies have examined the association between heavy metal contamination (including arsenic [As], cadmium [Cd], chromium [Cr], copper [Cu], mercury [Hg], nickel [Ni], lead [Pb], and zinc [Zn]) and lung cancer. However, data from previous studies on pathological cell types are limited, particularly regarding exposure to low-dose soil heavy metal contamination. The purpose of this study was to explore the association between soil heavy metal contamination and lung cancer incidence by specific cell type in Taiwan.

Methods: We conducted an ecological study and calculated the annual averages of eight soil heavy metals (i.e., As, Cd, Cr, Cu, Hg, Ni, Pb, and Zn) by using data from the Taiwan Environmental Protection Administration from1982 to 1986. The age-standardized incidence rates of lung cancer according to two major pathological types (adenocarcinoma [AC] and squamous cell carcinoma [SCC]) were obtained from the National Cancer Registry Program conducted in Taiwan from 2001 to 2005. A geographical information system was used to plot the maps of soil heavy metal concentration and lung cancer incidence rates. Poisson regression models were used to obtain the adjusted relative ratios (RR) and 95% confidence intervals (CI) for the lung cancer incidence associated with soil heavy metals.

Results: For males, the trend test for lung SCC incidence caused by exposure to Cr, Cu, Hg, Ni, and Zn showed a statistically significant dose-response relationship. However, for lung AC, only Cu and Ni had a significant dose-response relationship. As for females, those achieving a statistically significant dose-response relationship for the trend test were Cr (P = 0.02), Ni (P = 0.02), and Zn (P= 0.02) for lung SCC, and Cu (P < 0.01) and Zn (P = 0.02) for lung AC.

Conclusion: The current study suggests that a dose-response relationship exists between low-dose soil heavy metal concentration and lung cancer occurrence by specific cell-type; however, the relevant mechanism should be explored further.

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Related in: MedlinePlus

Spatial distributions of township soil heavy metal concentration (mg/kg) during 1982-1986 in Taiwan. Detailed legend: Spatial distributions of township soil heavy metal concentration (mg/kg) during 1982–1986 in Taiwan. (a) As, (b) Cd, (c) Cr, (d) Cu, (e) Hg, (f) Ni, (g) Pb, (h) Zn.
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Figure 1: Spatial distributions of township soil heavy metal concentration (mg/kg) during 1982-1986 in Taiwan. Detailed legend: Spatial distributions of township soil heavy metal concentration (mg/kg) during 1982–1986 in Taiwan. (a) As, (b) Cd, (c) Cr, (d) Cu, (e) Hg, (f) Ni, (g) Pb, (h) Zn.

Mentions: Figure 1 shows the distribution of the average concentrations of As (Figure 1a), Cd (Figure 1b), Cr (Figure 1c), Cu (Figure 1d), Hg (Figure 1e), Ni (Figure 1f), Pb (Figure 1g), and Zn (Figure 1h) in soil collected from the target townships during 1982–1986. The As concentration is higher in the southwestern coastal areas, and the Cd concentration is sporadically higher in northern and central Taiwan. Townships having higher Cr concentrations are in western and northeastern coastal areas. Cu concentration is sporadically high in Taiwan. Hg concentration is higher in the western coastal townships; Ni concentration is higher in the western and southeastern coastal townships. Pb and Zn concentrations have sporadic high values in Taiwan.


Cell-type specificity of lung cancer associated with low-dose soil heavy metal contamination in Taiwan: an ecological study.

Huang HH, Huang JY, Lung CC, Wu CL, Ho CC, Sun YH, Ko PC, Su SY, Chen SC, Liaw YP - BMC Public Health (2013)

Spatial distributions of township soil heavy metal concentration (mg/kg) during 1982-1986 in Taiwan. Detailed legend: Spatial distributions of township soil heavy metal concentration (mg/kg) during 1982–1986 in Taiwan. (a) As, (b) Cd, (c) Cr, (d) Cu, (e) Hg, (f) Ni, (g) Pb, (h) Zn.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3643867&req=5

Figure 1: Spatial distributions of township soil heavy metal concentration (mg/kg) during 1982-1986 in Taiwan. Detailed legend: Spatial distributions of township soil heavy metal concentration (mg/kg) during 1982–1986 in Taiwan. (a) As, (b) Cd, (c) Cr, (d) Cu, (e) Hg, (f) Ni, (g) Pb, (h) Zn.
Mentions: Figure 1 shows the distribution of the average concentrations of As (Figure 1a), Cd (Figure 1b), Cr (Figure 1c), Cu (Figure 1d), Hg (Figure 1e), Ni (Figure 1f), Pb (Figure 1g), and Zn (Figure 1h) in soil collected from the target townships during 1982–1986. The As concentration is higher in the southwestern coastal areas, and the Cd concentration is sporadically higher in northern and central Taiwan. Townships having higher Cr concentrations are in western and northeastern coastal areas. Cu concentration is sporadically high in Taiwan. Hg concentration is higher in the western coastal townships; Ni concentration is higher in the western and southeastern coastal townships. Pb and Zn concentrations have sporadic high values in Taiwan.

Bottom Line: For males, the trend test for lung SCC incidence caused by exposure to Cr, Cu, Hg, Ni, and Zn showed a statistically significant dose-response relationship.However, for lung AC, only Cu and Ni had a significant dose-response relationship.As for females, those achieving a statistically significant dose-response relationship for the trend test were Cr (P = 0.02), Ni (P = 0.02), and Zn (P= 0.02) for lung SCC, and Cu (P < 0.01) and Zn (P = 0.02) for lung AC.

View Article: PubMed Central - HTML - PubMed

Affiliation: Jen-Ai Hospital, Taichung City 41265, Taiwan.

ABSTRACT

Background: Numerous studies have examined the association between heavy metal contamination (including arsenic [As], cadmium [Cd], chromium [Cr], copper [Cu], mercury [Hg], nickel [Ni], lead [Pb], and zinc [Zn]) and lung cancer. However, data from previous studies on pathological cell types are limited, particularly regarding exposure to low-dose soil heavy metal contamination. The purpose of this study was to explore the association between soil heavy metal contamination and lung cancer incidence by specific cell type in Taiwan.

Methods: We conducted an ecological study and calculated the annual averages of eight soil heavy metals (i.e., As, Cd, Cr, Cu, Hg, Ni, Pb, and Zn) by using data from the Taiwan Environmental Protection Administration from1982 to 1986. The age-standardized incidence rates of lung cancer according to two major pathological types (adenocarcinoma [AC] and squamous cell carcinoma [SCC]) were obtained from the National Cancer Registry Program conducted in Taiwan from 2001 to 2005. A geographical information system was used to plot the maps of soil heavy metal concentration and lung cancer incidence rates. Poisson regression models were used to obtain the adjusted relative ratios (RR) and 95% confidence intervals (CI) for the lung cancer incidence associated with soil heavy metals.

Results: For males, the trend test for lung SCC incidence caused by exposure to Cr, Cu, Hg, Ni, and Zn showed a statistically significant dose-response relationship. However, for lung AC, only Cu and Ni had a significant dose-response relationship. As for females, those achieving a statistically significant dose-response relationship for the trend test were Cr (P = 0.02), Ni (P = 0.02), and Zn (P= 0.02) for lung SCC, and Cu (P < 0.01) and Zn (P = 0.02) for lung AC.

Conclusion: The current study suggests that a dose-response relationship exists between low-dose soil heavy metal concentration and lung cancer occurrence by specific cell-type; however, the relevant mechanism should be explored further.

Show MeSH
Related in: MedlinePlus