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Spontaneous pineal apoplexy in a pineal parenchymal tumor of intermediate differentiation.

Wang CC, Turner J, Steel T - Cancer Biol Med (2013)

Bottom Line: Pineal apoplexy is a rare clinical presentation of pineal parenchymal tumors.The paresis required an expeditious tumor resection.Clinical and radiological evidence of the cure 5 years post-surgery is available.

View Article: PubMed Central - PubMed

Affiliation: Nepean Hospital, Kingswood, NSW 2747, Australia;

ABSTRACT
Pineal apoplexy is a rare clinical presentation of pineal parenchymal tumors. We report the curative treatment of a case of pineal parenchymal tumor of intermediate differentiation with spontaneous apoplectic hemorrhage. This case is shown through computed tomography and magnetic resonance imaging of the brain, and is confirmed via histopathological studies. Recurrent upward gaze paresis was observed after the stereotactic biopsy. The paresis required an expeditious tumor resection. The mechanism of the pineal apoplectic hemorrhage remains unclear although it has been observed in different pineal region lesions. Clinical and radiological evidence of the cure 5 years post-surgery is available.

No MeSH data available.


Related in: MedlinePlus

Pineal parenchymal tumor of intermediate differentiation. A. Area of tumors with uniform round nuclei and nucleus-free pineocytomatous rosettes containing fine fibrillary material. One mitosis is seen (arrow) (H&E staining, 400×); B. More cellular area with mild nuclear atypia and no rosettes (H&E staining, 400×); C. Moderate numbers of neurofilament protein expression among the tumor cells (400×); D. Several Ki-67 labeled nuclei of tumor cells (400×).
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f2: Pineal parenchymal tumor of intermediate differentiation. A. Area of tumors with uniform round nuclei and nucleus-free pineocytomatous rosettes containing fine fibrillary material. One mitosis is seen (arrow) (H&E staining, 400×); B. More cellular area with mild nuclear atypia and no rosettes (H&E staining, 400×); C. Moderate numbers of neurofilament protein expression among the tumor cells (400×); D. Several Ki-67 labeled nuclei of tumor cells (400×).

Mentions: The histological studies revealed a moderate cellular tumor composed of small cells with round and generally uniform nuclei, fine chromatin, and small nucleoli. A few foci of cells with mild nuclear atypia were also found. Mitotic figures were rare (fewer than one per ten high-power field). Small pineocytomatous rosettes were focally found . Extensive hemorrhaging occurred in the adjacent granulation tissue, gliosis, and hemosiderin-laiden macrophages. The immunohistochemistry was positive for neurofilament, enolase, synaptophysin, and CD 56, but negative for NeuN . The Ki-67 proliferation index was 20% to 30% (Figure 2). The tumor was diagnosed as grade II PPTID based on the standards of World Health Organization (WHO).


Spontaneous pineal apoplexy in a pineal parenchymal tumor of intermediate differentiation.

Wang CC, Turner J, Steel T - Cancer Biol Med (2013)

Pineal parenchymal tumor of intermediate differentiation. A. Area of tumors with uniform round nuclei and nucleus-free pineocytomatous rosettes containing fine fibrillary material. One mitosis is seen (arrow) (H&E staining, 400×); B. More cellular area with mild nuclear atypia and no rosettes (H&E staining, 400×); C. Moderate numbers of neurofilament protein expression among the tumor cells (400×); D. Several Ki-67 labeled nuclei of tumor cells (400×).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3643688&req=5

f2: Pineal parenchymal tumor of intermediate differentiation. A. Area of tumors with uniform round nuclei and nucleus-free pineocytomatous rosettes containing fine fibrillary material. One mitosis is seen (arrow) (H&E staining, 400×); B. More cellular area with mild nuclear atypia and no rosettes (H&E staining, 400×); C. Moderate numbers of neurofilament protein expression among the tumor cells (400×); D. Several Ki-67 labeled nuclei of tumor cells (400×).
Mentions: The histological studies revealed a moderate cellular tumor composed of small cells with round and generally uniform nuclei, fine chromatin, and small nucleoli. A few foci of cells with mild nuclear atypia were also found. Mitotic figures were rare (fewer than one per ten high-power field). Small pineocytomatous rosettes were focally found . Extensive hemorrhaging occurred in the adjacent granulation tissue, gliosis, and hemosiderin-laiden macrophages. The immunohistochemistry was positive for neurofilament, enolase, synaptophysin, and CD 56, but negative for NeuN . The Ki-67 proliferation index was 20% to 30% (Figure 2). The tumor was diagnosed as grade II PPTID based on the standards of World Health Organization (WHO).

Bottom Line: Pineal apoplexy is a rare clinical presentation of pineal parenchymal tumors.The paresis required an expeditious tumor resection.Clinical and radiological evidence of the cure 5 years post-surgery is available.

View Article: PubMed Central - PubMed

Affiliation: Nepean Hospital, Kingswood, NSW 2747, Australia;

ABSTRACT
Pineal apoplexy is a rare clinical presentation of pineal parenchymal tumors. We report the curative treatment of a case of pineal parenchymal tumor of intermediate differentiation with spontaneous apoplectic hemorrhage. This case is shown through computed tomography and magnetic resonance imaging of the brain, and is confirmed via histopathological studies. Recurrent upward gaze paresis was observed after the stereotactic biopsy. The paresis required an expeditious tumor resection. The mechanism of the pineal apoplectic hemorrhage remains unclear although it has been observed in different pineal region lesions. Clinical and radiological evidence of the cure 5 years post-surgery is available.

No MeSH data available.


Related in: MedlinePlus