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Adenoid cystic carcinoma in the maxillary gingiva: a case report and immunohistochemical study.

Zhao C, Liu JZ, Wang SB, Wang SC - Cancer Biol Med (2013)

Bottom Line: Clinical examination revealed an ulcer in the left upper molar gingiva, with swelling in the region from the second premolar to the third molar.X-ray images demonstrated the involvement of the maxillary alveolar bone.In this case, no recurrence or distant metastasis was observed after 2 years of follow-up.

View Article: PubMed Central - PubMed

Affiliation: Zhengzhou University School and Hospital of Stomatology, Zhengzhou 450000, China; ; Department of Pathology, The Fourth Affiliated Hospital of Zhengzhou University, Zhengzhou 450044, China.

ABSTRACT
Gingival adenoid cystic carcinoma (ACC) is a rare malignancy. We describe the diagnosis and treatment of a 43 year-old woman who presented with a persistent oral ulcer for approximately 1 year, and subsequent pain in the left posterior maxillary region. Clinical examination revealed an ulcer in the left upper molar gingiva, with swelling in the region from the second premolar to the third molar. X-ray images demonstrated the involvement of the maxillary alveolar bone. The histopathological and immunohistochemical features were diagnostic of ACC. ACC is often presented as a gingival lesion; thus, it may easily be neglected by patients. The identification of this tumor using specific pathological analyses prevents misdiagnosis and enables clinicians to determine the appropriate treatment. In this case, no recurrence or distant metastasis was observed after 2 years of follow-up.

No MeSH data available.


Related in: MedlinePlus

Micrographs of the ACC stained with hematoxylin and eosin. A. Prominent solid and microcystic patterns of the ACC with the ulcer margins (200×); B. Details of the ACC, showing a cribriform pattern and its tumor cells (400×).
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f2: Micrographs of the ACC stained with hematoxylin and eosin. A. Prominent solid and microcystic patterns of the ACC with the ulcer margins (200×); B. Details of the ACC, showing a cribriform pattern and its tumor cells (400×).

Mentions: Upon admission, malignant mesenchymal or odontogenic neoplasia was suspected. An incisional biopsy was then performed under local anesthesia. The histopathological and immunohistochemical features were diagnostic of ACC. Microscopic examination showed prominent solid, microcystic, and focally tubular glandular patterns of growth, as well as numerous cells with myoepithelial characteristics and a few luminal cells. The histopathological features were similar to those of the solid subtype of salivary gland ACC (Figure 2). A panel of antibodies (Dako, USA) was used for immunohistochemical evaluation, namely, those for cytokeratins (CK5, 05/16B4; CK7, OV-TL12/30), smooth muscle actin (SMA, 1A4), p63 (4A4), and Ki-67 (MIB-1).


Adenoid cystic carcinoma in the maxillary gingiva: a case report and immunohistochemical study.

Zhao C, Liu JZ, Wang SB, Wang SC - Cancer Biol Med (2013)

Micrographs of the ACC stained with hematoxylin and eosin. A. Prominent solid and microcystic patterns of the ACC with the ulcer margins (200×); B. Details of the ACC, showing a cribriform pattern and its tumor cells (400×).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3643682&req=5

f2: Micrographs of the ACC stained with hematoxylin and eosin. A. Prominent solid and microcystic patterns of the ACC with the ulcer margins (200×); B. Details of the ACC, showing a cribriform pattern and its tumor cells (400×).
Mentions: Upon admission, malignant mesenchymal or odontogenic neoplasia was suspected. An incisional biopsy was then performed under local anesthesia. The histopathological and immunohistochemical features were diagnostic of ACC. Microscopic examination showed prominent solid, microcystic, and focally tubular glandular patterns of growth, as well as numerous cells with myoepithelial characteristics and a few luminal cells. The histopathological features were similar to those of the solid subtype of salivary gland ACC (Figure 2). A panel of antibodies (Dako, USA) was used for immunohistochemical evaluation, namely, those for cytokeratins (CK5, 05/16B4; CK7, OV-TL12/30), smooth muscle actin (SMA, 1A4), p63 (4A4), and Ki-67 (MIB-1).

Bottom Line: Clinical examination revealed an ulcer in the left upper molar gingiva, with swelling in the region from the second premolar to the third molar.X-ray images demonstrated the involvement of the maxillary alveolar bone.In this case, no recurrence or distant metastasis was observed after 2 years of follow-up.

View Article: PubMed Central - PubMed

Affiliation: Zhengzhou University School and Hospital of Stomatology, Zhengzhou 450000, China; ; Department of Pathology, The Fourth Affiliated Hospital of Zhengzhou University, Zhengzhou 450044, China.

ABSTRACT
Gingival adenoid cystic carcinoma (ACC) is a rare malignancy. We describe the diagnosis and treatment of a 43 year-old woman who presented with a persistent oral ulcer for approximately 1 year, and subsequent pain in the left posterior maxillary region. Clinical examination revealed an ulcer in the left upper molar gingiva, with swelling in the region from the second premolar to the third molar. X-ray images demonstrated the involvement of the maxillary alveolar bone. The histopathological and immunohistochemical features were diagnostic of ACC. ACC is often presented as a gingival lesion; thus, it may easily be neglected by patients. The identification of this tumor using specific pathological analyses prevents misdiagnosis and enables clinicians to determine the appropriate treatment. In this case, no recurrence or distant metastasis was observed after 2 years of follow-up.

No MeSH data available.


Related in: MedlinePlus