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High Serum CEA and CYFRA21-1 Levels after a Two-Cycle Adjuvant Chemotherapy for NSCLC: Possible Poor Prognostic Factors.

Lin XF, Wang XD, Sun DQ, Li Z, Bai Y - Cancer Biol Med (2012)

Bottom Line: A high CEA level was a poor prognostic factor (RR 1.152) for DFS.The median survival time (MST) of the high CEA level group was 26 months, whereas that of the normal group was 61 months (P<0.0001).The median DFS time of the high CEA group and the normal group was 34 and 53 months, respectively (P<0.0001).

View Article: PubMed Central - PubMed

Affiliation: Tianjin Medical College, Tianjin 300222, China.

ABSTRACT

Objective: The aim of this study was to test whether carcinoembryonic antigen (CEA) and cytokeratin 19 fragments (CYFRA21-1) can be used as a prognostic factor for non-small-cell lung cancer (NSCLC) after two cycles of adjuvant chemotherapy in NSCLC patients.

Methods: A total of 169 patients underwent at least two cycles of adjuvant chemotherapy. The serum levels of CEA and CYFRA21-1 were recorded after the second cycle of chemotherapy, and the patient follow-up was conducted. Overall survival (OS) and disease-free survival (DFS) were used as the primary endpoint and the secondary endpoint, respectively.

Results: The high levels of CEA and CYFRA21-1 after two cycles of adjuvant chemotherapy were poor prognostic factors for OS, with risk ratios (RR) of 2.003 and 1.702, respectively. A high CEA level was a poor prognostic factor (RR 1.152) for DFS. The median survival time (MST) of the high CEA level group was 26 months, whereas that of the normal group was 61 months (P<0.0001). The median DFS time of the high CEA group and the normal group was 34 and 53 months, respectively (P<0.0001). The MST of the high CYFRA21-1 group and the normal group was 43 and 56 months, respectively (P<0.0001).

Conclusions: The high serum levels of CEA or CYFRA21-1 after two cycles of adjuvant chemotherapy are poor prognostic factors for NSCLC patients.

No MeSH data available.


Related in: MedlinePlus

Kaplan-Meier survival curve of DFS for the high (abnormal, ≥3.3 ng/mL) and normal CYFRA21-1 level (<3.3 ng/mL) patients.
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f3: Kaplan-Meier survival curve of DFS for the high (abnormal, ≥3.3 ng/mL) and normal CYFRA21-1 level (<3.3 ng/mL) patients.

Mentions: Comparison of the OS between the high (abnormal) serum CYFRA21-1 level group (CYFRA21-1 ≥3.3 ng/mL) and the normal level group (CYFRA21-1 <3.3 ng/mL) is shown in Table 6 and Figure 3. The MST of patients with high CYFRA21-1 level was significantly shorter than that of those with normal CYFRA21-1 level (43 months vs. 56 months, P<0.0001).


High Serum CEA and CYFRA21-1 Levels after a Two-Cycle Adjuvant Chemotherapy for NSCLC: Possible Poor Prognostic Factors.

Lin XF, Wang XD, Sun DQ, Li Z, Bai Y - Cancer Biol Med (2012)

Kaplan-Meier survival curve of DFS for the high (abnormal, ≥3.3 ng/mL) and normal CYFRA21-1 level (<3.3 ng/mL) patients.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3643679&req=5

f3: Kaplan-Meier survival curve of DFS for the high (abnormal, ≥3.3 ng/mL) and normal CYFRA21-1 level (<3.3 ng/mL) patients.
Mentions: Comparison of the OS between the high (abnormal) serum CYFRA21-1 level group (CYFRA21-1 ≥3.3 ng/mL) and the normal level group (CYFRA21-1 <3.3 ng/mL) is shown in Table 6 and Figure 3. The MST of patients with high CYFRA21-1 level was significantly shorter than that of those with normal CYFRA21-1 level (43 months vs. 56 months, P<0.0001).

Bottom Line: A high CEA level was a poor prognostic factor (RR 1.152) for DFS.The median survival time (MST) of the high CEA level group was 26 months, whereas that of the normal group was 61 months (P<0.0001).The median DFS time of the high CEA group and the normal group was 34 and 53 months, respectively (P<0.0001).

View Article: PubMed Central - PubMed

Affiliation: Tianjin Medical College, Tianjin 300222, China.

ABSTRACT

Objective: The aim of this study was to test whether carcinoembryonic antigen (CEA) and cytokeratin 19 fragments (CYFRA21-1) can be used as a prognostic factor for non-small-cell lung cancer (NSCLC) after two cycles of adjuvant chemotherapy in NSCLC patients.

Methods: A total of 169 patients underwent at least two cycles of adjuvant chemotherapy. The serum levels of CEA and CYFRA21-1 were recorded after the second cycle of chemotherapy, and the patient follow-up was conducted. Overall survival (OS) and disease-free survival (DFS) were used as the primary endpoint and the secondary endpoint, respectively.

Results: The high levels of CEA and CYFRA21-1 after two cycles of adjuvant chemotherapy were poor prognostic factors for OS, with risk ratios (RR) of 2.003 and 1.702, respectively. A high CEA level was a poor prognostic factor (RR 1.152) for DFS. The median survival time (MST) of the high CEA level group was 26 months, whereas that of the normal group was 61 months (P<0.0001). The median DFS time of the high CEA group and the normal group was 34 and 53 months, respectively (P<0.0001). The MST of the high CYFRA21-1 group and the normal group was 43 and 56 months, respectively (P<0.0001).

Conclusions: The high serum levels of CEA or CYFRA21-1 after two cycles of adjuvant chemotherapy are poor prognostic factors for NSCLC patients.

No MeSH data available.


Related in: MedlinePlus