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Functionalized gold nanorods for tumor imaging and targeted therapy.

Gui C, Cui DX - Cancer Biol Med (2012)

Bottom Line: Gold nanorods, as an emerging noble metal nanomaterial with unique properties, have become the new exciting focus of theoretical and experimental studies in the past few years.The structure and function of gold nanorods, especially their biocompatibility, optical property, and photothermal effects, have been attracting more and more attention.We also explore other prospective applications and discuss the corresponding concepts, issues, approaches, and challenges, with the aim of stimulating broader interest in gold nanorod-based nanotechnology and improving its practical application.

View Article: PubMed Central - PubMed

Affiliation: Department of Bio-Nano Science and Engineering, Key Laboratory for Thin Film and Microfabrication of the Ministry of Education, Institute of Micro-Nano Science and Technology, Shanghai Jiaotong University, Shanghai 200240, China.

ABSTRACT
Gold nanorods, as an emerging noble metal nanomaterial with unique properties, have become the new exciting focus of theoretical and experimental studies in the past few years. The structure and function of gold nanorods, especially their biocompatibility, optical property, and photothermal effects, have been attracting more and more attention. Gold nanorods exhibit great potential in applications such as tumor molecular imaging and photothermal therapy. In this article, we review some of the main advances made over the past few years in the application of gold nanorods in surface functionalization, molecular imaging, and photothermal therapy. We also explore other prospective applications and discuss the corresponding concepts, issues, approaches, and challenges, with the aim of stimulating broader interest in gold nanorod-based nanotechnology and improving its practical application.

No MeSH data available.


Related in: MedlinePlus

Light scattering images and intracellular location of RGD-dGNRs. Reflective mode dark-field images and bright images of RGD-dGNRs (A), dGNRs (B), and free peptide RGD-dGNRs (C) after incubation with A375 cells for 30 min at room temperature. The images were acquired with a Zeiss Axioscope2 microscope imaging system. A1: Bright-field image of A375 cells incubated with RGD-dGNRs exhibiting cell shapes. A2: Dark-field image of A375 cells incubated with RGD-dGNR nanoprobes exhibiting golden color. B1: Bright-field image of A375 cells incubated with dGNRs exhibiting cell shapes. B2: Dark-field image of A375 cells incubated with RGD-dGNR nanoprobes exhibiting black color. C1: Bright-field image of A375 cells incubated with free peptide and RGD-dGNRs exhibiting cell shapes. C2: Dark-field image of melanoma A375 cells incubated with free peptide and RGD-dGNRs, exhibiting black color. D1 and D2: TEM images of RGD-dGNRs (arrow) in the cytoplasm of melanoma A375 cells, left scale bar, 500 nm; right scale bar, 200 nm. Reprinted with permission from [24], Li Z, Huang P, Zhang X, et al. RGD-conjugated dendrimer-modified gold nanorods for in vivo tumor targeting and photothermal therapy. Mol Pharm 2010; 7: 94-104.
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f9: Light scattering images and intracellular location of RGD-dGNRs. Reflective mode dark-field images and bright images of RGD-dGNRs (A), dGNRs (B), and free peptide RGD-dGNRs (C) after incubation with A375 cells for 30 min at room temperature. The images were acquired with a Zeiss Axioscope2 microscope imaging system. A1: Bright-field image of A375 cells incubated with RGD-dGNRs exhibiting cell shapes. A2: Dark-field image of A375 cells incubated with RGD-dGNR nanoprobes exhibiting golden color. B1: Bright-field image of A375 cells incubated with dGNRs exhibiting cell shapes. B2: Dark-field image of A375 cells incubated with RGD-dGNR nanoprobes exhibiting black color. C1: Bright-field image of A375 cells incubated with free peptide and RGD-dGNRs exhibiting cell shapes. C2: Dark-field image of melanoma A375 cells incubated with free peptide and RGD-dGNRs, exhibiting black color. D1 and D2: TEM images of RGD-dGNRs (arrow) in the cytoplasm of melanoma A375 cells, left scale bar, 500 nm; right scale bar, 200 nm. Reprinted with permission from [24], Li Z, Huang P, Zhang X, et al. RGD-conjugated dendrimer-modified gold nanorods for in vivo tumor targeting and photothermal therapy. Mol Pharm 2010; 7: 94-104.

Mentions: Li et al.[24] also evaluated the specificity and sensitivity of RGD-dGNR nanoprobes in tumor cell targeting. Melanoma A375 cells incubated with RGD-dGNR nanoprobes exhibited a strong golden color, whereas the melanoma A375 cells incubated with free RGD peptides and pre-incubated with free RGD peptides did not exhibit a golden color. RGD-dGNR nanoprobes were located on the surface and in the cytoplasm of the melanoma A375 cells (Figure 9). This finding suggests that RGD-dGNR nanoprobes can specifically target melanoma A375 cells.


Functionalized gold nanorods for tumor imaging and targeted therapy.

Gui C, Cui DX - Cancer Biol Med (2012)

Light scattering images and intracellular location of RGD-dGNRs. Reflective mode dark-field images and bright images of RGD-dGNRs (A), dGNRs (B), and free peptide RGD-dGNRs (C) after incubation with A375 cells for 30 min at room temperature. The images were acquired with a Zeiss Axioscope2 microscope imaging system. A1: Bright-field image of A375 cells incubated with RGD-dGNRs exhibiting cell shapes. A2: Dark-field image of A375 cells incubated with RGD-dGNR nanoprobes exhibiting golden color. B1: Bright-field image of A375 cells incubated with dGNRs exhibiting cell shapes. B2: Dark-field image of A375 cells incubated with RGD-dGNR nanoprobes exhibiting black color. C1: Bright-field image of A375 cells incubated with free peptide and RGD-dGNRs exhibiting cell shapes. C2: Dark-field image of melanoma A375 cells incubated with free peptide and RGD-dGNRs, exhibiting black color. D1 and D2: TEM images of RGD-dGNRs (arrow) in the cytoplasm of melanoma A375 cells, left scale bar, 500 nm; right scale bar, 200 nm. Reprinted with permission from [24], Li Z, Huang P, Zhang X, et al. RGD-conjugated dendrimer-modified gold nanorods for in vivo tumor targeting and photothermal therapy. Mol Pharm 2010; 7: 94-104.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3643678&req=5

f9: Light scattering images and intracellular location of RGD-dGNRs. Reflective mode dark-field images and bright images of RGD-dGNRs (A), dGNRs (B), and free peptide RGD-dGNRs (C) after incubation with A375 cells for 30 min at room temperature. The images were acquired with a Zeiss Axioscope2 microscope imaging system. A1: Bright-field image of A375 cells incubated with RGD-dGNRs exhibiting cell shapes. A2: Dark-field image of A375 cells incubated with RGD-dGNR nanoprobes exhibiting golden color. B1: Bright-field image of A375 cells incubated with dGNRs exhibiting cell shapes. B2: Dark-field image of A375 cells incubated with RGD-dGNR nanoprobes exhibiting black color. C1: Bright-field image of A375 cells incubated with free peptide and RGD-dGNRs exhibiting cell shapes. C2: Dark-field image of melanoma A375 cells incubated with free peptide and RGD-dGNRs, exhibiting black color. D1 and D2: TEM images of RGD-dGNRs (arrow) in the cytoplasm of melanoma A375 cells, left scale bar, 500 nm; right scale bar, 200 nm. Reprinted with permission from [24], Li Z, Huang P, Zhang X, et al. RGD-conjugated dendrimer-modified gold nanorods for in vivo tumor targeting and photothermal therapy. Mol Pharm 2010; 7: 94-104.
Mentions: Li et al.[24] also evaluated the specificity and sensitivity of RGD-dGNR nanoprobes in tumor cell targeting. Melanoma A375 cells incubated with RGD-dGNR nanoprobes exhibited a strong golden color, whereas the melanoma A375 cells incubated with free RGD peptides and pre-incubated with free RGD peptides did not exhibit a golden color. RGD-dGNR nanoprobes were located on the surface and in the cytoplasm of the melanoma A375 cells (Figure 9). This finding suggests that RGD-dGNR nanoprobes can specifically target melanoma A375 cells.

Bottom Line: Gold nanorods, as an emerging noble metal nanomaterial with unique properties, have become the new exciting focus of theoretical and experimental studies in the past few years.The structure and function of gold nanorods, especially their biocompatibility, optical property, and photothermal effects, have been attracting more and more attention.We also explore other prospective applications and discuss the corresponding concepts, issues, approaches, and challenges, with the aim of stimulating broader interest in gold nanorod-based nanotechnology and improving its practical application.

View Article: PubMed Central - PubMed

Affiliation: Department of Bio-Nano Science and Engineering, Key Laboratory for Thin Film and Microfabrication of the Ministry of Education, Institute of Micro-Nano Science and Technology, Shanghai Jiaotong University, Shanghai 200240, China.

ABSTRACT
Gold nanorods, as an emerging noble metal nanomaterial with unique properties, have become the new exciting focus of theoretical and experimental studies in the past few years. The structure and function of gold nanorods, especially their biocompatibility, optical property, and photothermal effects, have been attracting more and more attention. Gold nanorods exhibit great potential in applications such as tumor molecular imaging and photothermal therapy. In this article, we review some of the main advances made over the past few years in the application of gold nanorods in surface functionalization, molecular imaging, and photothermal therapy. We also explore other prospective applications and discuss the corresponding concepts, issues, approaches, and challenges, with the aim of stimulating broader interest in gold nanorod-based nanotechnology and improving its practical application.

No MeSH data available.


Related in: MedlinePlus