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Functionalized gold nanorods for tumor imaging and targeted therapy.

Gui C, Cui DX - Cancer Biol Med (2012)

Bottom Line: Gold nanorods, as an emerging noble metal nanomaterial with unique properties, have become the new exciting focus of theoretical and experimental studies in the past few years.The structure and function of gold nanorods, especially their biocompatibility, optical property, and photothermal effects, have been attracting more and more attention.We also explore other prospective applications and discuss the corresponding concepts, issues, approaches, and challenges, with the aim of stimulating broader interest in gold nanorod-based nanotechnology and improving its practical application.

View Article: PubMed Central - PubMed

Affiliation: Department of Bio-Nano Science and Engineering, Key Laboratory for Thin Film and Microfabrication of the Ministry of Education, Institute of Micro-Nano Science and Technology, Shanghai Jiaotong University, Shanghai 200240, China.

ABSTRACT
Gold nanorods, as an emerging noble metal nanomaterial with unique properties, have become the new exciting focus of theoretical and experimental studies in the past few years. The structure and function of gold nanorods, especially their biocompatibility, optical property, and photothermal effects, have been attracting more and more attention. Gold nanorods exhibit great potential in applications such as tumor molecular imaging and photothermal therapy. In this article, we review some of the main advances made over the past few years in the application of gold nanorods in surface functionalization, molecular imaging, and photothermal therapy. We also explore other prospective applications and discuss the corresponding concepts, issues, approaches, and challenges, with the aim of stimulating broader interest in gold nanorod-based nanotechnology and improving its practical application.

No MeSH data available.


Related in: MedlinePlus

Real-time in vivo X-ray images after intravenous injection of GNR-SiO2-FA into nude mice at different point in time. A: Photograph of the tumor tissue; B: X-ray image at 0 h; C: X-ray image at 0 h (in color); D: X-ray image at 12 h; E: X-ray image at 12 h (in color); F: X-ray image at 24 h (in color). Reprinted with permission from [40], Huang P, Bao L, Zhang CL, et al. Folic acid-conjugated Silica-modified gold nanorods for X-ray/CT imaging-guided dual-mode radiation and photo-thermal therapy. Biomaterials 2011; 32: 9796-9809.
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f8: Real-time in vivo X-ray images after intravenous injection of GNR-SiO2-FA into nude mice at different point in time. A: Photograph of the tumor tissue; B: X-ray image at 0 h; C: X-ray image at 0 h (in color); D: X-ray image at 12 h; E: X-ray image at 12 h (in color); F: X-ray image at 24 h (in color). Reprinted with permission from [40], Huang P, Bao L, Zhang CL, et al. Folic acid-conjugated Silica-modified gold nanorods for X-ray/CT imaging-guided dual-mode radiation and photo-thermal therapy. Biomaterials 2011; 32: 9796-9809.

Mentions: Aside from the abovementioned excellent effects, Huang et al.’s study[40] showed that GNR-SiO2 could be utilized as a positive X-ray or CT imaging contrast agent. Figure 6A indicates that CT intensity continuously increased as the concentration of GNR-SiO2 increased. Moreover, the two had a well-correlated linear relationship as shown in Figure 6B. They also demonstrated the feasibility of GNR-SiO2-FA in in vivo X-ray imaging by injecting 5 mg and 1 mg of GNR-SiO2-FA into the back and right rear flank area of mice, respectively. As shown in Figure 7, the subcutaneous injection sites displayed a much more enhanced positive contrast than the other soft tissues. By lengthening the injection time, positive contrast became more and more clear. In addition, the researchers employed X-ray imaging to monitor the tumor tissue-targeting ability of GNR-SiO2-FA during blood circulation. Figure 8 shows real-time in vivo X-ray images of nude mice after being injected with GNR-SiO2-FA at different points in time. The results showed that gastric cancer cells were targeted by GNR-SiO2-FA with high specificity.


Functionalized gold nanorods for tumor imaging and targeted therapy.

Gui C, Cui DX - Cancer Biol Med (2012)

Real-time in vivo X-ray images after intravenous injection of GNR-SiO2-FA into nude mice at different point in time. A: Photograph of the tumor tissue; B: X-ray image at 0 h; C: X-ray image at 0 h (in color); D: X-ray image at 12 h; E: X-ray image at 12 h (in color); F: X-ray image at 24 h (in color). Reprinted with permission from [40], Huang P, Bao L, Zhang CL, et al. Folic acid-conjugated Silica-modified gold nanorods for X-ray/CT imaging-guided dual-mode radiation and photo-thermal therapy. Biomaterials 2011; 32: 9796-9809.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3643678&req=5

f8: Real-time in vivo X-ray images after intravenous injection of GNR-SiO2-FA into nude mice at different point in time. A: Photograph of the tumor tissue; B: X-ray image at 0 h; C: X-ray image at 0 h (in color); D: X-ray image at 12 h; E: X-ray image at 12 h (in color); F: X-ray image at 24 h (in color). Reprinted with permission from [40], Huang P, Bao L, Zhang CL, et al. Folic acid-conjugated Silica-modified gold nanorods for X-ray/CT imaging-guided dual-mode radiation and photo-thermal therapy. Biomaterials 2011; 32: 9796-9809.
Mentions: Aside from the abovementioned excellent effects, Huang et al.’s study[40] showed that GNR-SiO2 could be utilized as a positive X-ray or CT imaging contrast agent. Figure 6A indicates that CT intensity continuously increased as the concentration of GNR-SiO2 increased. Moreover, the two had a well-correlated linear relationship as shown in Figure 6B. They also demonstrated the feasibility of GNR-SiO2-FA in in vivo X-ray imaging by injecting 5 mg and 1 mg of GNR-SiO2-FA into the back and right rear flank area of mice, respectively. As shown in Figure 7, the subcutaneous injection sites displayed a much more enhanced positive contrast than the other soft tissues. By lengthening the injection time, positive contrast became more and more clear. In addition, the researchers employed X-ray imaging to monitor the tumor tissue-targeting ability of GNR-SiO2-FA during blood circulation. Figure 8 shows real-time in vivo X-ray images of nude mice after being injected with GNR-SiO2-FA at different points in time. The results showed that gastric cancer cells were targeted by GNR-SiO2-FA with high specificity.

Bottom Line: Gold nanorods, as an emerging noble metal nanomaterial with unique properties, have become the new exciting focus of theoretical and experimental studies in the past few years.The structure and function of gold nanorods, especially their biocompatibility, optical property, and photothermal effects, have been attracting more and more attention.We also explore other prospective applications and discuss the corresponding concepts, issues, approaches, and challenges, with the aim of stimulating broader interest in gold nanorod-based nanotechnology and improving its practical application.

View Article: PubMed Central - PubMed

Affiliation: Department of Bio-Nano Science and Engineering, Key Laboratory for Thin Film and Microfabrication of the Ministry of Education, Institute of Micro-Nano Science and Technology, Shanghai Jiaotong University, Shanghai 200240, China.

ABSTRACT
Gold nanorods, as an emerging noble metal nanomaterial with unique properties, have become the new exciting focus of theoretical and experimental studies in the past few years. The structure and function of gold nanorods, especially their biocompatibility, optical property, and photothermal effects, have been attracting more and more attention. Gold nanorods exhibit great potential in applications such as tumor molecular imaging and photothermal therapy. In this article, we review some of the main advances made over the past few years in the application of gold nanorods in surface functionalization, molecular imaging, and photothermal therapy. We also explore other prospective applications and discuss the corresponding concepts, issues, approaches, and challenges, with the aim of stimulating broader interest in gold nanorod-based nanotechnology and improving its practical application.

No MeSH data available.


Related in: MedlinePlus