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Functionalized gold nanorods for tumor imaging and targeted therapy.

Gui C, Cui DX - Cancer Biol Med (2012)

Bottom Line: Gold nanorods, as an emerging noble metal nanomaterial with unique properties, have become the new exciting focus of theoretical and experimental studies in the past few years.The structure and function of gold nanorods, especially their biocompatibility, optical property, and photothermal effects, have been attracting more and more attention.We also explore other prospective applications and discuss the corresponding concepts, issues, approaches, and challenges, with the aim of stimulating broader interest in gold nanorod-based nanotechnology and improving its practical application.

View Article: PubMed Central - PubMed

Affiliation: Department of Bio-Nano Science and Engineering, Key Laboratory for Thin Film and Microfabrication of the Ministry of Education, Institute of Micro-Nano Science and Technology, Shanghai Jiaotong University, Shanghai 200240, China.

ABSTRACT
Gold nanorods, as an emerging noble metal nanomaterial with unique properties, have become the new exciting focus of theoretical and experimental studies in the past few years. The structure and function of gold nanorods, especially their biocompatibility, optical property, and photothermal effects, have been attracting more and more attention. Gold nanorods exhibit great potential in applications such as tumor molecular imaging and photothermal therapy. In this article, we review some of the main advances made over the past few years in the application of gold nanorods in surface functionalization, molecular imaging, and photothermal therapy. We also explore other prospective applications and discuss the corresponding concepts, issues, approaches, and challenges, with the aim of stimulating broader interest in gold nanorod-based nanotechnology and improving its practical application.

No MeSH data available.


Related in: MedlinePlus

Effects of photothermal therapy on MGC803 cells incubated with 12.5 µM of GNR-SiO2-FA for 24 h at 37°C in the dark prior to irradiation for 3 min with an nm laser. A and B: MGC803 cells at the center of the laser spot. C and D: MGC803 cells on the boundary of the laser spot. A and C: Bright field, B and D: Fluorescence field. Reprinted with permission from [40], Huang P, Bao L, Zhang CL, et al. Folic acid-conjugated Silica-modified gold nanorods for X-ray/CT imaging-guided dual-mode radiation and photo-thermal therapy. Biomaterials 2011; 32: 9796-9809.
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f5: Effects of photothermal therapy on MGC803 cells incubated with 12.5 µM of GNR-SiO2-FA for 24 h at 37°C in the dark prior to irradiation for 3 min with an nm laser. A and B: MGC803 cells at the center of the laser spot. C and D: MGC803 cells on the boundary of the laser spot. A and C: Bright field, B and D: Fluorescence field. Reprinted with permission from [40], Huang P, Bao L, Zhang CL, et al. Folic acid-conjugated Silica-modified gold nanorods for X-ray/CT imaging-guided dual-mode radiation and photo-thermal therapy. Biomaterials 2011; 32: 9796-9809.

Mentions: The researchers also tested the effects of GNR-SiO2-FA nanoprobes on photothermal therapy. Figure 5Aand5B) indicated that the MGC803 cells at the center of the laser spot were killed by the GNR-SiO2-FA upon irradiation. The cells on the boundary of the laser spot did not receive irradiation; they appeared spindle-like and did not exhibit red fluorescence as shown in Figure 5Cand5D).


Functionalized gold nanorods for tumor imaging and targeted therapy.

Gui C, Cui DX - Cancer Biol Med (2012)

Effects of photothermal therapy on MGC803 cells incubated with 12.5 µM of GNR-SiO2-FA for 24 h at 37°C in the dark prior to irradiation for 3 min with an nm laser. A and B: MGC803 cells at the center of the laser spot. C and D: MGC803 cells on the boundary of the laser spot. A and C: Bright field, B and D: Fluorescence field. Reprinted with permission from [40], Huang P, Bao L, Zhang CL, et al. Folic acid-conjugated Silica-modified gold nanorods for X-ray/CT imaging-guided dual-mode radiation and photo-thermal therapy. Biomaterials 2011; 32: 9796-9809.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3643678&req=5

f5: Effects of photothermal therapy on MGC803 cells incubated with 12.5 µM of GNR-SiO2-FA for 24 h at 37°C in the dark prior to irradiation for 3 min with an nm laser. A and B: MGC803 cells at the center of the laser spot. C and D: MGC803 cells on the boundary of the laser spot. A and C: Bright field, B and D: Fluorescence field. Reprinted with permission from [40], Huang P, Bao L, Zhang CL, et al. Folic acid-conjugated Silica-modified gold nanorods for X-ray/CT imaging-guided dual-mode radiation and photo-thermal therapy. Biomaterials 2011; 32: 9796-9809.
Mentions: The researchers also tested the effects of GNR-SiO2-FA nanoprobes on photothermal therapy. Figure 5Aand5B) indicated that the MGC803 cells at the center of the laser spot were killed by the GNR-SiO2-FA upon irradiation. The cells on the boundary of the laser spot did not receive irradiation; they appeared spindle-like and did not exhibit red fluorescence as shown in Figure 5Cand5D).

Bottom Line: Gold nanorods, as an emerging noble metal nanomaterial with unique properties, have become the new exciting focus of theoretical and experimental studies in the past few years.The structure and function of gold nanorods, especially their biocompatibility, optical property, and photothermal effects, have been attracting more and more attention.We also explore other prospective applications and discuss the corresponding concepts, issues, approaches, and challenges, with the aim of stimulating broader interest in gold nanorod-based nanotechnology and improving its practical application.

View Article: PubMed Central - PubMed

Affiliation: Department of Bio-Nano Science and Engineering, Key Laboratory for Thin Film and Microfabrication of the Ministry of Education, Institute of Micro-Nano Science and Technology, Shanghai Jiaotong University, Shanghai 200240, China.

ABSTRACT
Gold nanorods, as an emerging noble metal nanomaterial with unique properties, have become the new exciting focus of theoretical and experimental studies in the past few years. The structure and function of gold nanorods, especially their biocompatibility, optical property, and photothermal effects, have been attracting more and more attention. Gold nanorods exhibit great potential in applications such as tumor molecular imaging and photothermal therapy. In this article, we review some of the main advances made over the past few years in the application of gold nanorods in surface functionalization, molecular imaging, and photothermal therapy. We also explore other prospective applications and discuss the corresponding concepts, issues, approaches, and challenges, with the aim of stimulating broader interest in gold nanorod-based nanotechnology and improving its practical application.

No MeSH data available.


Related in: MedlinePlus