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Functionalized gold nanorods for tumor imaging and targeted therapy.

Gui C, Cui DX - Cancer Biol Med (2012)

Bottom Line: Gold nanorods, as an emerging noble metal nanomaterial with unique properties, have become the new exciting focus of theoretical and experimental studies in the past few years.The structure and function of gold nanorods, especially their biocompatibility, optical property, and photothermal effects, have been attracting more and more attention.We also explore other prospective applications and discuss the corresponding concepts, issues, approaches, and challenges, with the aim of stimulating broader interest in gold nanorod-based nanotechnology and improving its practical application.

View Article: PubMed Central - PubMed

Affiliation: Department of Bio-Nano Science and Engineering, Key Laboratory for Thin Film and Microfabrication of the Ministry of Education, Institute of Micro-Nano Science and Technology, Shanghai Jiaotong University, Shanghai 200240, China.

ABSTRACT
Gold nanorods, as an emerging noble metal nanomaterial with unique properties, have become the new exciting focus of theoretical and experimental studies in the past few years. The structure and function of gold nanorods, especially their biocompatibility, optical property, and photothermal effects, have been attracting more and more attention. Gold nanorods exhibit great potential in applications such as tumor molecular imaging and photothermal therapy. In this article, we review some of the main advances made over the past few years in the application of gold nanorods in surface functionalization, molecular imaging, and photothermal therapy. We also explore other prospective applications and discuss the corresponding concepts, issues, approaches, and challenges, with the aim of stimulating broader interest in gold nanorod-based nanotechnology and improving its practical application.

No MeSH data available.


Related in: MedlinePlus

Proliferation (A) and cell viability (B) of MGC803 cells incubated with 100 µL of GNR-SiO2-FA in varying concentrations for 24 h at 6 Gy of X-ray irradiation. In the photographs (A), the top column of the cells did not receive irradiation; the bottom column of the cells received irradiation. Reprinted with permission from [40], Huang P, Bao L, Zhang CL, et al. Folic acid-conjugated Silica-modified gold nanorods for X-ray/CT imaging-guided dual-mode radiation and photo-thermal therapy. Biomaterials 2011; 32: 9796-9809.
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f4: Proliferation (A) and cell viability (B) of MGC803 cells incubated with 100 µL of GNR-SiO2-FA in varying concentrations for 24 h at 6 Gy of X-ray irradiation. In the photographs (A), the top column of the cells did not receive irradiation; the bottom column of the cells received irradiation. Reprinted with permission from [40], Huang P, Bao L, Zhang CL, et al. Folic acid-conjugated Silica-modified gold nanorods for X-ray/CT imaging-guided dual-mode radiation and photo-thermal therapy. Biomaterials 2011; 32: 9796-9809.

Mentions: The prepared nanoprobes displayed highly selective targeting, enhanced RT effects, and excellent PTT effects on the gastric cancer cells; the nanoprobes also exhibited strong X-ray attenuation in in vivo X-ray/CT imaging. In their experiment, Huang et al. incubated the MGC803 cells with varying concentrations of GNR-SiO2-FA to determine whether GNR-SiO2-FA can enhance the radiosensitivity of the MGC803 cells to different doses of X-ray irradiation. Figure 4A shows the proliferation of the MGC803 cells with and without irradiation. The number of colonies decreased with the increase in the concentration of GNR-SiO2-FA. Cell viability was normalized to that of the control cells (no drug and no irradiation) as shown in Figure 4B.


Functionalized gold nanorods for tumor imaging and targeted therapy.

Gui C, Cui DX - Cancer Biol Med (2012)

Proliferation (A) and cell viability (B) of MGC803 cells incubated with 100 µL of GNR-SiO2-FA in varying concentrations for 24 h at 6 Gy of X-ray irradiation. In the photographs (A), the top column of the cells did not receive irradiation; the bottom column of the cells received irradiation. Reprinted with permission from [40], Huang P, Bao L, Zhang CL, et al. Folic acid-conjugated Silica-modified gold nanorods for X-ray/CT imaging-guided dual-mode radiation and photo-thermal therapy. Biomaterials 2011; 32: 9796-9809.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3643678&req=5

f4: Proliferation (A) and cell viability (B) of MGC803 cells incubated with 100 µL of GNR-SiO2-FA in varying concentrations for 24 h at 6 Gy of X-ray irradiation. In the photographs (A), the top column of the cells did not receive irradiation; the bottom column of the cells received irradiation. Reprinted with permission from [40], Huang P, Bao L, Zhang CL, et al. Folic acid-conjugated Silica-modified gold nanorods for X-ray/CT imaging-guided dual-mode radiation and photo-thermal therapy. Biomaterials 2011; 32: 9796-9809.
Mentions: The prepared nanoprobes displayed highly selective targeting, enhanced RT effects, and excellent PTT effects on the gastric cancer cells; the nanoprobes also exhibited strong X-ray attenuation in in vivo X-ray/CT imaging. In their experiment, Huang et al. incubated the MGC803 cells with varying concentrations of GNR-SiO2-FA to determine whether GNR-SiO2-FA can enhance the radiosensitivity of the MGC803 cells to different doses of X-ray irradiation. Figure 4A shows the proliferation of the MGC803 cells with and without irradiation. The number of colonies decreased with the increase in the concentration of GNR-SiO2-FA. Cell viability was normalized to that of the control cells (no drug and no irradiation) as shown in Figure 4B.

Bottom Line: Gold nanorods, as an emerging noble metal nanomaterial with unique properties, have become the new exciting focus of theoretical and experimental studies in the past few years.The structure and function of gold nanorods, especially their biocompatibility, optical property, and photothermal effects, have been attracting more and more attention.We also explore other prospective applications and discuss the corresponding concepts, issues, approaches, and challenges, with the aim of stimulating broader interest in gold nanorod-based nanotechnology and improving its practical application.

View Article: PubMed Central - PubMed

Affiliation: Department of Bio-Nano Science and Engineering, Key Laboratory for Thin Film and Microfabrication of the Ministry of Education, Institute of Micro-Nano Science and Technology, Shanghai Jiaotong University, Shanghai 200240, China.

ABSTRACT
Gold nanorods, as an emerging noble metal nanomaterial with unique properties, have become the new exciting focus of theoretical and experimental studies in the past few years. The structure and function of gold nanorods, especially their biocompatibility, optical property, and photothermal effects, have been attracting more and more attention. Gold nanorods exhibit great potential in applications such as tumor molecular imaging and photothermal therapy. In this article, we review some of the main advances made over the past few years in the application of gold nanorods in surface functionalization, molecular imaging, and photothermal therapy. We also explore other prospective applications and discuss the corresponding concepts, issues, approaches, and challenges, with the aim of stimulating broader interest in gold nanorod-based nanotechnology and improving its practical application.

No MeSH data available.


Related in: MedlinePlus