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Functionalized gold nanorods for tumor imaging and targeted therapy.

Gui C, Cui DX - Cancer Biol Med (2012)

Bottom Line: Gold nanorods, as an emerging noble metal nanomaterial with unique properties, have become the new exciting focus of theoretical and experimental studies in the past few years.The structure and function of gold nanorods, especially their biocompatibility, optical property, and photothermal effects, have been attracting more and more attention.We also explore other prospective applications and discuss the corresponding concepts, issues, approaches, and challenges, with the aim of stimulating broader interest in gold nanorod-based nanotechnology and improving its practical application.

View Article: PubMed Central - PubMed

Affiliation: Department of Bio-Nano Science and Engineering, Key Laboratory for Thin Film and Microfabrication of the Ministry of Education, Institute of Micro-Nano Science and Technology, Shanghai Jiaotong University, Shanghai 200240, China.

ABSTRACT
Gold nanorods, as an emerging noble metal nanomaterial with unique properties, have become the new exciting focus of theoretical and experimental studies in the past few years. The structure and function of gold nanorods, especially their biocompatibility, optical property, and photothermal effects, have been attracting more and more attention. Gold nanorods exhibit great potential in applications such as tumor molecular imaging and photothermal therapy. In this article, we review some of the main advances made over the past few years in the application of gold nanorods in surface functionalization, molecular imaging, and photothermal therapy. We also explore other prospective applications and discuss the corresponding concepts, issues, approaches, and challenges, with the aim of stimulating broader interest in gold nanorod-based nanotechnology and improving its practical application.

No MeSH data available.


Related in: MedlinePlus

Modification process of GNRs. Reprinted with permission from [33], Orendorff CJ, Alam TM, Sasaki DY, et al. Phospholipid− Gold Nanorod Composites. ACS Nano 2009; 3: 971-983.
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f2: Modification process of GNRs. Reprinted with permission from [33], Orendorff CJ, Alam TM, Sasaki DY, et al. Phospholipid− Gold Nanorod Composites. ACS Nano 2009; 3: 971-983.

Mentions: The team of Christopher J. Orendorff et al.[33] utilized the vesicle fusion approach to form a lipid bilayer on gold nanorods and demonstrated its formation. The CTAB layer was replaced by POPC liposomes, and the excess was removed with the final concentration of 40 µL in 1 mL. Figure 2 shows the modification process. The lipid-gold nanorod composites have zwitterionic functionality. Compared with as-prepared CTAB-gold nanorods, the POPC-modified composites were ~30 mv charge. The CTAB-gold nanorods self-assembled into disordered arrangements because of end-to-end or end-to-side electrostatic repulsion, whereas the lipid-gold nanorod composites assembled side-to-side in short-range order at pH 7.0. By decreasing pH, the lipid-gold nanorod structures would disassemble because of their cationic and repulsive surface potential.


Functionalized gold nanorods for tumor imaging and targeted therapy.

Gui C, Cui DX - Cancer Biol Med (2012)

Modification process of GNRs. Reprinted with permission from [33], Orendorff CJ, Alam TM, Sasaki DY, et al. Phospholipid− Gold Nanorod Composites. ACS Nano 2009; 3: 971-983.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3643678&req=5

f2: Modification process of GNRs. Reprinted with permission from [33], Orendorff CJ, Alam TM, Sasaki DY, et al. Phospholipid− Gold Nanorod Composites. ACS Nano 2009; 3: 971-983.
Mentions: The team of Christopher J. Orendorff et al.[33] utilized the vesicle fusion approach to form a lipid bilayer on gold nanorods and demonstrated its formation. The CTAB layer was replaced by POPC liposomes, and the excess was removed with the final concentration of 40 µL in 1 mL. Figure 2 shows the modification process. The lipid-gold nanorod composites have zwitterionic functionality. Compared with as-prepared CTAB-gold nanorods, the POPC-modified composites were ~30 mv charge. The CTAB-gold nanorods self-assembled into disordered arrangements because of end-to-end or end-to-side electrostatic repulsion, whereas the lipid-gold nanorod composites assembled side-to-side in short-range order at pH 7.0. By decreasing pH, the lipid-gold nanorod structures would disassemble because of their cationic and repulsive surface potential.

Bottom Line: Gold nanorods, as an emerging noble metal nanomaterial with unique properties, have become the new exciting focus of theoretical and experimental studies in the past few years.The structure and function of gold nanorods, especially their biocompatibility, optical property, and photothermal effects, have been attracting more and more attention.We also explore other prospective applications and discuss the corresponding concepts, issues, approaches, and challenges, with the aim of stimulating broader interest in gold nanorod-based nanotechnology and improving its practical application.

View Article: PubMed Central - PubMed

Affiliation: Department of Bio-Nano Science and Engineering, Key Laboratory for Thin Film and Microfabrication of the Ministry of Education, Institute of Micro-Nano Science and Technology, Shanghai Jiaotong University, Shanghai 200240, China.

ABSTRACT
Gold nanorods, as an emerging noble metal nanomaterial with unique properties, have become the new exciting focus of theoretical and experimental studies in the past few years. The structure and function of gold nanorods, especially their biocompatibility, optical property, and photothermal effects, have been attracting more and more attention. Gold nanorods exhibit great potential in applications such as tumor molecular imaging and photothermal therapy. In this article, we review some of the main advances made over the past few years in the application of gold nanorods in surface functionalization, molecular imaging, and photothermal therapy. We also explore other prospective applications and discuss the corresponding concepts, issues, approaches, and challenges, with the aim of stimulating broader interest in gold nanorod-based nanotechnology and improving its practical application.

No MeSH data available.


Related in: MedlinePlus