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Functionalized gold nanorods for tumor imaging and targeted therapy.

Gui C, Cui DX - Cancer Biol Med (2012)

Bottom Line: Gold nanorods, as an emerging noble metal nanomaterial with unique properties, have become the new exciting focus of theoretical and experimental studies in the past few years.The structure and function of gold nanorods, especially their biocompatibility, optical property, and photothermal effects, have been attracting more and more attention.We also explore other prospective applications and discuss the corresponding concepts, issues, approaches, and challenges, with the aim of stimulating broader interest in gold nanorod-based nanotechnology and improving its practical application.

View Article: PubMed Central - PubMed

Affiliation: Department of Bio-Nano Science and Engineering, Key Laboratory for Thin Film and Microfabrication of the Ministry of Education, Institute of Micro-Nano Science and Technology, Shanghai Jiaotong University, Shanghai 200240, China.

ABSTRACT
Gold nanorods, as an emerging noble metal nanomaterial with unique properties, have become the new exciting focus of theoretical and experimental studies in the past few years. The structure and function of gold nanorods, especially their biocompatibility, optical property, and photothermal effects, have been attracting more and more attention. Gold nanorods exhibit great potential in applications such as tumor molecular imaging and photothermal therapy. In this article, we review some of the main advances made over the past few years in the application of gold nanorods in surface functionalization, molecular imaging, and photothermal therapy. We also explore other prospective applications and discuss the corresponding concepts, issues, approaches, and challenges, with the aim of stimulating broader interest in gold nanorod-based nanotechnology and improving its practical application.

No MeSH data available.


Related in: MedlinePlus

Schematic of different reaction conditions used to control the morphology and chirality of gold nanocrystals. Reprinted with permission from [41], Huang P, Pandoli O, Wang X, et al. Chiral guanosine 5’-monophosphate-capped gold nanoflowers: Controllable synthesis, characterization, surface-enhanced Raman scattering activity, cellular imaging and photothermal therapy. Nano Res 2012: 5: 630-639.
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f14: Schematic of different reaction conditions used to control the morphology and chirality of gold nanocrystals. Reprinted with permission from [41], Huang P, Pandoli O, Wang X, et al. Chiral guanosine 5’-monophosphate-capped gold nanoflowers: Controllable synthesis, characterization, surface-enhanced Raman scattering activity, cellular imaging and photothermal therapy. Nano Res 2012: 5: 630-639.

Mentions: Recently, nanogold species with various shapes have been developed because of their surface- and morphology-dependent properties. Huang et al.[41] studied the simple one-pot green synthesis of chiral GNFs with abundant petal-shaped tips by chloroauric acid with L-ascorbic acid (L-AA) as a reducing agent in the presence of a 5’-GMP nucleotide. As shown in Figure 14, when the reducing agent was L-AA, the obtained nanocrystals were flower-like in shape and produced an LSPR band over 570 nm. The synthesized nanocrystals were quasi-spherical, consisting of a solid core with many (>10) short, irregular, and obtuse branches (Figure 15A). Figure 15B displays an individual flower-like nanocrystal with highly asymmetrical metallic surface morphology. Figure 15C shows a petal-shaped tip as a single-crystalline protrusion from the core of the nanoflower. The corresponding selected area electron diffraction (SAED) pattern of the area containing many GNFs is shown in Figure 15D. The figure also reveals that the nanoflowers are crystalline and randomly oriented.


Functionalized gold nanorods for tumor imaging and targeted therapy.

Gui C, Cui DX - Cancer Biol Med (2012)

Schematic of different reaction conditions used to control the morphology and chirality of gold nanocrystals. Reprinted with permission from [41], Huang P, Pandoli O, Wang X, et al. Chiral guanosine 5’-monophosphate-capped gold nanoflowers: Controllable synthesis, characterization, surface-enhanced Raman scattering activity, cellular imaging and photothermal therapy. Nano Res 2012: 5: 630-639.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3643678&req=5

f14: Schematic of different reaction conditions used to control the morphology and chirality of gold nanocrystals. Reprinted with permission from [41], Huang P, Pandoli O, Wang X, et al. Chiral guanosine 5’-monophosphate-capped gold nanoflowers: Controllable synthesis, characterization, surface-enhanced Raman scattering activity, cellular imaging and photothermal therapy. Nano Res 2012: 5: 630-639.
Mentions: Recently, nanogold species with various shapes have been developed because of their surface- and morphology-dependent properties. Huang et al.[41] studied the simple one-pot green synthesis of chiral GNFs with abundant petal-shaped tips by chloroauric acid with L-ascorbic acid (L-AA) as a reducing agent in the presence of a 5’-GMP nucleotide. As shown in Figure 14, when the reducing agent was L-AA, the obtained nanocrystals were flower-like in shape and produced an LSPR band over 570 nm. The synthesized nanocrystals were quasi-spherical, consisting of a solid core with many (>10) short, irregular, and obtuse branches (Figure 15A). Figure 15B displays an individual flower-like nanocrystal with highly asymmetrical metallic surface morphology. Figure 15C shows a petal-shaped tip as a single-crystalline protrusion from the core of the nanoflower. The corresponding selected area electron diffraction (SAED) pattern of the area containing many GNFs is shown in Figure 15D. The figure also reveals that the nanoflowers are crystalline and randomly oriented.

Bottom Line: Gold nanorods, as an emerging noble metal nanomaterial with unique properties, have become the new exciting focus of theoretical and experimental studies in the past few years.The structure and function of gold nanorods, especially their biocompatibility, optical property, and photothermal effects, have been attracting more and more attention.We also explore other prospective applications and discuss the corresponding concepts, issues, approaches, and challenges, with the aim of stimulating broader interest in gold nanorod-based nanotechnology and improving its practical application.

View Article: PubMed Central - PubMed

Affiliation: Department of Bio-Nano Science and Engineering, Key Laboratory for Thin Film and Microfabrication of the Ministry of Education, Institute of Micro-Nano Science and Technology, Shanghai Jiaotong University, Shanghai 200240, China.

ABSTRACT
Gold nanorods, as an emerging noble metal nanomaterial with unique properties, have become the new exciting focus of theoretical and experimental studies in the past few years. The structure and function of gold nanorods, especially their biocompatibility, optical property, and photothermal effects, have been attracting more and more attention. Gold nanorods exhibit great potential in applications such as tumor molecular imaging and photothermal therapy. In this article, we review some of the main advances made over the past few years in the application of gold nanorods in surface functionalization, molecular imaging, and photothermal therapy. We also explore other prospective applications and discuss the corresponding concepts, issues, approaches, and challenges, with the aim of stimulating broader interest in gold nanorod-based nanotechnology and improving its practical application.

No MeSH data available.


Related in: MedlinePlus