Limits...
Functionalized gold nanorods for tumor imaging and targeted therapy.

Gui C, Cui DX - Cancer Biol Med (2012)

Bottom Line: Gold nanorods, as an emerging noble metal nanomaterial with unique properties, have become the new exciting focus of theoretical and experimental studies in the past few years.The structure and function of gold nanorods, especially their biocompatibility, optical property, and photothermal effects, have been attracting more and more attention.We also explore other prospective applications and discuss the corresponding concepts, issues, approaches, and challenges, with the aim of stimulating broader interest in gold nanorod-based nanotechnology and improving its practical application.

View Article: PubMed Central - PubMed

Affiliation: Department of Bio-Nano Science and Engineering, Key Laboratory for Thin Film and Microfabrication of the Ministry of Education, Institute of Micro-Nano Science and Technology, Shanghai Jiaotong University, Shanghai 200240, China.

ABSTRACT
Gold nanorods, as an emerging noble metal nanomaterial with unique properties, have become the new exciting focus of theoretical and experimental studies in the past few years. The structure and function of gold nanorods, especially their biocompatibility, optical property, and photothermal effects, have been attracting more and more attention. Gold nanorods exhibit great potential in applications such as tumor molecular imaging and photothermal therapy. In this article, we review some of the main advances made over the past few years in the application of gold nanorods in surface functionalization, molecular imaging, and photothermal therapy. We also explore other prospective applications and discuss the corresponding concepts, issues, approaches, and challenges, with the aim of stimulating broader interest in gold nanorod-based nanotechnology and improving its practical application.

No MeSH data available.


Related in: MedlinePlus

RCM images and histological images of the tumor seven weeks after treatment. A: RCM images (0.25 mm × 0.25 mm) of the tumor were acquired with a VivaScope 3000 microscope (Lucid) using a diode laser with a wavelength of 830 nm and an objective lens with 30× numerical aperture (NA) and 0.9 water immersion. A1: Arrows point to the numerous gossamer-like collagen bundles and branch-like collagens. A2 and A3: Arrows point to the reflective melanoma cells existing in a low-density and sparse cluster. B: Corresponding histological images (20×) of the tumor after H&E staining as well as laser irradiation in the group of RGD-dGNRs (B1), group of PBS after laser irradiation (B2), and the untreated control group (B3). B1: Scar-like structure containing numerous collagen bundles in the tumor location. B2: Existence of numerous tumor cells. B3: Existence of numerous tumor cells. Reprinted with permission from [24], Li Z, Huang P, Zhang X, et al. RGD-conjugated dendrimer-modified gold nanorods for in vivo tumor targeting and photothermal therapy. mol pharm 2010; 7: 94-104.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3643678&req=5

f12: RCM images and histological images of the tumor seven weeks after treatment. A: RCM images (0.25 mm × 0.25 mm) of the tumor were acquired with a VivaScope 3000 microscope (Lucid) using a diode laser with a wavelength of 830 nm and an objective lens with 30× numerical aperture (NA) and 0.9 water immersion. A1: Arrows point to the numerous gossamer-like collagen bundles and branch-like collagens. A2 and A3: Arrows point to the reflective melanoma cells existing in a low-density and sparse cluster. B: Corresponding histological images (20×) of the tumor after H&E staining as well as laser irradiation in the group of RGD-dGNRs (B1), group of PBS after laser irradiation (B2), and the untreated control group (B3). B1: Scar-like structure containing numerous collagen bundles in the tumor location. B2: Existence of numerous tumor cells. B3: Existence of numerous tumor cells. Reprinted with permission from [24], Li Z, Huang P, Zhang X, et al. RGD-conjugated dendrimer-modified gold nanorods for in vivo tumor targeting and photothermal therapy. mol pharm 2010; 7: 94-104.

Mentions: Li et al.’s study also investigated the potential mechanism of RGD-dGNR nanoprobe-based photothermal therapy by real-time reflectance confocal microscopy (RCM). The RCM images of the tumors in the test group displayed plenty of gossamer-like collagen bundles and branch-like collagens (white arrow in Figure 12A1). Numerous reflective melanoma cells also existed in the control group (Figure 12A1 and A2). In the test group (Figure 12B1), a scar-like structure containing numerous collagen bundles was observed. Numerous tumor cells were also observed in the control group (Figure 12B2 and B3).


Functionalized gold nanorods for tumor imaging and targeted therapy.

Gui C, Cui DX - Cancer Biol Med (2012)

RCM images and histological images of the tumor seven weeks after treatment. A: RCM images (0.25 mm × 0.25 mm) of the tumor were acquired with a VivaScope 3000 microscope (Lucid) using a diode laser with a wavelength of 830 nm and an objective lens with 30× numerical aperture (NA) and 0.9 water immersion. A1: Arrows point to the numerous gossamer-like collagen bundles and branch-like collagens. A2 and A3: Arrows point to the reflective melanoma cells existing in a low-density and sparse cluster. B: Corresponding histological images (20×) of the tumor after H&E staining as well as laser irradiation in the group of RGD-dGNRs (B1), group of PBS after laser irradiation (B2), and the untreated control group (B3). B1: Scar-like structure containing numerous collagen bundles in the tumor location. B2: Existence of numerous tumor cells. B3: Existence of numerous tumor cells. Reprinted with permission from [24], Li Z, Huang P, Zhang X, et al. RGD-conjugated dendrimer-modified gold nanorods for in vivo tumor targeting and photothermal therapy. mol pharm 2010; 7: 94-104.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3643678&req=5

f12: RCM images and histological images of the tumor seven weeks after treatment. A: RCM images (0.25 mm × 0.25 mm) of the tumor were acquired with a VivaScope 3000 microscope (Lucid) using a diode laser with a wavelength of 830 nm and an objective lens with 30× numerical aperture (NA) and 0.9 water immersion. A1: Arrows point to the numerous gossamer-like collagen bundles and branch-like collagens. A2 and A3: Arrows point to the reflective melanoma cells existing in a low-density and sparse cluster. B: Corresponding histological images (20×) of the tumor after H&E staining as well as laser irradiation in the group of RGD-dGNRs (B1), group of PBS after laser irradiation (B2), and the untreated control group (B3). B1: Scar-like structure containing numerous collagen bundles in the tumor location. B2: Existence of numerous tumor cells. B3: Existence of numerous tumor cells. Reprinted with permission from [24], Li Z, Huang P, Zhang X, et al. RGD-conjugated dendrimer-modified gold nanorods for in vivo tumor targeting and photothermal therapy. mol pharm 2010; 7: 94-104.
Mentions: Li et al.’s study also investigated the potential mechanism of RGD-dGNR nanoprobe-based photothermal therapy by real-time reflectance confocal microscopy (RCM). The RCM images of the tumors in the test group displayed plenty of gossamer-like collagen bundles and branch-like collagens (white arrow in Figure 12A1). Numerous reflective melanoma cells also existed in the control group (Figure 12A1 and A2). In the test group (Figure 12B1), a scar-like structure containing numerous collagen bundles was observed. Numerous tumor cells were also observed in the control group (Figure 12B2 and B3).

Bottom Line: Gold nanorods, as an emerging noble metal nanomaterial with unique properties, have become the new exciting focus of theoretical and experimental studies in the past few years.The structure and function of gold nanorods, especially their biocompatibility, optical property, and photothermal effects, have been attracting more and more attention.We also explore other prospective applications and discuss the corresponding concepts, issues, approaches, and challenges, with the aim of stimulating broader interest in gold nanorod-based nanotechnology and improving its practical application.

View Article: PubMed Central - PubMed

Affiliation: Department of Bio-Nano Science and Engineering, Key Laboratory for Thin Film and Microfabrication of the Ministry of Education, Institute of Micro-Nano Science and Technology, Shanghai Jiaotong University, Shanghai 200240, China.

ABSTRACT
Gold nanorods, as an emerging noble metal nanomaterial with unique properties, have become the new exciting focus of theoretical and experimental studies in the past few years. The structure and function of gold nanorods, especially their biocompatibility, optical property, and photothermal effects, have been attracting more and more attention. Gold nanorods exhibit great potential in applications such as tumor molecular imaging and photothermal therapy. In this article, we review some of the main advances made over the past few years in the application of gold nanorods in surface functionalization, molecular imaging, and photothermal therapy. We also explore other prospective applications and discuss the corresponding concepts, issues, approaches, and challenges, with the aim of stimulating broader interest in gold nanorod-based nanotechnology and improving its practical application.

No MeSH data available.


Related in: MedlinePlus