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Functionalized gold nanorods for tumor imaging and targeted therapy.

Gui C, Cui DX - Cancer Biol Med (2012)

Bottom Line: Gold nanorods, as an emerging noble metal nanomaterial with unique properties, have become the new exciting focus of theoretical and experimental studies in the past few years.The structure and function of gold nanorods, especially their biocompatibility, optical property, and photothermal effects, have been attracting more and more attention.We also explore other prospective applications and discuss the corresponding concepts, issues, approaches, and challenges, with the aim of stimulating broader interest in gold nanorod-based nanotechnology and improving its practical application.

View Article: PubMed Central - PubMed

Affiliation: Department of Bio-Nano Science and Engineering, Key Laboratory for Thin Film and Microfabrication of the Ministry of Education, Institute of Micro-Nano Science and Technology, Shanghai Jiaotong University, Shanghai 200240, China.

ABSTRACT
Gold nanorods, as an emerging noble metal nanomaterial with unique properties, have become the new exciting focus of theoretical and experimental studies in the past few years. The structure and function of gold nanorods, especially their biocompatibility, optical property, and photothermal effects, have been attracting more and more attention. Gold nanorods exhibit great potential in applications such as tumor molecular imaging and photothermal therapy. In this article, we review some of the main advances made over the past few years in the application of gold nanorods in surface functionalization, molecular imaging, and photothermal therapy. We also explore other prospective applications and discuss the corresponding concepts, issues, approaches, and challenges, with the aim of stimulating broader interest in gold nanorod-based nanotechnology and improving its practical application.

No MeSH data available.


Related in: MedlinePlus

Melanoma animal models, biodistribution of RGD-dGNRs, and survival data analysis of control and test group. A: A375 melanoma mouse models. The tumor size can be calculated as ab2/2 (a represents the longer dimension and b represents the shorter dimension of the tumor). B: Biodistribution of RGD-dGNRs in mice after intravenous injection. After injection, the gold amounts in the tissue samples were evaluated through ICP mass spectrometry (n=3). C: Tumor size at different points after the irradiation of mice treated with RGD-dGNRs and NIR laser (group 1); PBS and NIR laser (group 2) or untreated control (group 3), P<0.05 for group 2 or group 3 vs. group 1. D: Kaplan-Meier curve of the test group and control group, P=0.006. Reprinted with permission from [24], Li Z, Huang P, Zhang X, et al. RGD-conjugated dendrimer-modified gold nanorods for in vivo tumor targeting and photothermal therapy. Mol Pharm 2010; 7: 94-104.
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f11: Melanoma animal models, biodistribution of RGD-dGNRs, and survival data analysis of control and test group. A: A375 melanoma mouse models. The tumor size can be calculated as ab2/2 (a represents the longer dimension and b represents the shorter dimension of the tumor). B: Biodistribution of RGD-dGNRs in mice after intravenous injection. After injection, the gold amounts in the tissue samples were evaluated through ICP mass spectrometry (n=3). C: Tumor size at different points after the irradiation of mice treated with RGD-dGNRs and NIR laser (group 1); PBS and NIR laser (group 2) or untreated control (group 3), P<0.05 for group 2 or group 3 vs. group 1. D: Kaplan-Meier curve of the test group and control group, P=0.006. Reprinted with permission from [24], Li Z, Huang P, Zhang X, et al. RGD-conjugated dendrimer-modified gold nanorods for in vivo tumor targeting and photothermal therapy. Mol Pharm 2010; 7: 94-104.

Mentions: Figure 11A shows mouse models with melanoma A375 cells. The nanoprobes in the tumor tissues increased gradually as time increased (Figure 11B). Seventeen percent of the RGD-dGNR nanoprobes accumulated in the local tumor tissues at 6 hours after injection. Thus, six hours was selected as the optimal time to begin the NIR laser irradiation on the tumor locations. As the laser irradiation time and mouse breeding time increased, the size of the tumor in the test group became smaller and smaller. On the contrary, the tumor grew larger and larger in the control group (Figure 11C). The Kaplan-Meier curve (Figure 11D) suggested that the therapy based on nanoprobe injection and NIR laser irradiation can markedly increase the survival time of mice with tumors.


Functionalized gold nanorods for tumor imaging and targeted therapy.

Gui C, Cui DX - Cancer Biol Med (2012)

Melanoma animal models, biodistribution of RGD-dGNRs, and survival data analysis of control and test group. A: A375 melanoma mouse models. The tumor size can be calculated as ab2/2 (a represents the longer dimension and b represents the shorter dimension of the tumor). B: Biodistribution of RGD-dGNRs in mice after intravenous injection. After injection, the gold amounts in the tissue samples were evaluated through ICP mass spectrometry (n=3). C: Tumor size at different points after the irradiation of mice treated with RGD-dGNRs and NIR laser (group 1); PBS and NIR laser (group 2) or untreated control (group 3), P<0.05 for group 2 or group 3 vs. group 1. D: Kaplan-Meier curve of the test group and control group, P=0.006. Reprinted with permission from [24], Li Z, Huang P, Zhang X, et al. RGD-conjugated dendrimer-modified gold nanorods for in vivo tumor targeting and photothermal therapy. Mol Pharm 2010; 7: 94-104.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3643678&req=5

f11: Melanoma animal models, biodistribution of RGD-dGNRs, and survival data analysis of control and test group. A: A375 melanoma mouse models. The tumor size can be calculated as ab2/2 (a represents the longer dimension and b represents the shorter dimension of the tumor). B: Biodistribution of RGD-dGNRs in mice after intravenous injection. After injection, the gold amounts in the tissue samples were evaluated through ICP mass spectrometry (n=3). C: Tumor size at different points after the irradiation of mice treated with RGD-dGNRs and NIR laser (group 1); PBS and NIR laser (group 2) or untreated control (group 3), P<0.05 for group 2 or group 3 vs. group 1. D: Kaplan-Meier curve of the test group and control group, P=0.006. Reprinted with permission from [24], Li Z, Huang P, Zhang X, et al. RGD-conjugated dendrimer-modified gold nanorods for in vivo tumor targeting and photothermal therapy. Mol Pharm 2010; 7: 94-104.
Mentions: Figure 11A shows mouse models with melanoma A375 cells. The nanoprobes in the tumor tissues increased gradually as time increased (Figure 11B). Seventeen percent of the RGD-dGNR nanoprobes accumulated in the local tumor tissues at 6 hours after injection. Thus, six hours was selected as the optimal time to begin the NIR laser irradiation on the tumor locations. As the laser irradiation time and mouse breeding time increased, the size of the tumor in the test group became smaller and smaller. On the contrary, the tumor grew larger and larger in the control group (Figure 11C). The Kaplan-Meier curve (Figure 11D) suggested that the therapy based on nanoprobe injection and NIR laser irradiation can markedly increase the survival time of mice with tumors.

Bottom Line: Gold nanorods, as an emerging noble metal nanomaterial with unique properties, have become the new exciting focus of theoretical and experimental studies in the past few years.The structure and function of gold nanorods, especially their biocompatibility, optical property, and photothermal effects, have been attracting more and more attention.We also explore other prospective applications and discuss the corresponding concepts, issues, approaches, and challenges, with the aim of stimulating broader interest in gold nanorod-based nanotechnology and improving its practical application.

View Article: PubMed Central - PubMed

Affiliation: Department of Bio-Nano Science and Engineering, Key Laboratory for Thin Film and Microfabrication of the Ministry of Education, Institute of Micro-Nano Science and Technology, Shanghai Jiaotong University, Shanghai 200240, China.

ABSTRACT
Gold nanorods, as an emerging noble metal nanomaterial with unique properties, have become the new exciting focus of theoretical and experimental studies in the past few years. The structure and function of gold nanorods, especially their biocompatibility, optical property, and photothermal effects, have been attracting more and more attention. Gold nanorods exhibit great potential in applications such as tumor molecular imaging and photothermal therapy. In this article, we review some of the main advances made over the past few years in the application of gold nanorods in surface functionalization, molecular imaging, and photothermal therapy. We also explore other prospective applications and discuss the corresponding concepts, issues, approaches, and challenges, with the aim of stimulating broader interest in gold nanorod-based nanotechnology and improving its practical application.

No MeSH data available.


Related in: MedlinePlus