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Functionalized gold nanorods for tumor imaging and targeted therapy.

Gui C, Cui DX - Cancer Biol Med (2012)

Bottom Line: Gold nanorods, as an emerging noble metal nanomaterial with unique properties, have become the new exciting focus of theoretical and experimental studies in the past few years.The structure and function of gold nanorods, especially their biocompatibility, optical property, and photothermal effects, have been attracting more and more attention.We also explore other prospective applications and discuss the corresponding concepts, issues, approaches, and challenges, with the aim of stimulating broader interest in gold nanorod-based nanotechnology and improving its practical application.

View Article: PubMed Central - PubMed

Affiliation: Department of Bio-Nano Science and Engineering, Key Laboratory for Thin Film and Microfabrication of the Ministry of Education, Institute of Micro-Nano Science and Technology, Shanghai Jiaotong University, Shanghai 200240, China.

ABSTRACT
Gold nanorods, as an emerging noble metal nanomaterial with unique properties, have become the new exciting focus of theoretical and experimental studies in the past few years. The structure and function of gold nanorods, especially their biocompatibility, optical property, and photothermal effects, have been attracting more and more attention. Gold nanorods exhibit great potential in applications such as tumor molecular imaging and photothermal therapy. In this article, we review some of the main advances made over the past few years in the application of gold nanorods in surface functionalization, molecular imaging, and photothermal therapy. We also explore other prospective applications and discuss the corresponding concepts, issues, approaches, and challenges, with the aim of stimulating broader interest in gold nanorod-based nanotechnology and improving its practical application.

No MeSH data available.


Related in: MedlinePlus

A: The cells treated with G4.0-NR-RGD conjugation start to be injured at 70mW (9 W/cm2) and are obviously injured at 110mW (14 W/cm2). A1 and A2: The cells treated with pure gold nanorods; A3 and A4: The cells are not affected; A5 and A6: NIR light alone. B: Cell viability assessed via calcein staining. B1: No dead cells in the test group with 0.1 µg/mL of RGD-dGNRs. B2: No dead cells in the test group with 5 µg/mL of RGD-dGNRs. B3: Cell death and disappearance within the spot in the test group with 100 µg/mL of RGD-dGNRs. Reprinted with permission from [24], Li Z, Huang P, Zhang X, et al. RGD-conjugated dendrimer-modified gold nanorods for in vivo tumor targeting and photothermal therapy. Mol Pharm 2010; 7: 94-104.
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f10: A: The cells treated with G4.0-NR-RGD conjugation start to be injured at 70mW (9 W/cm2) and are obviously injured at 110mW (14 W/cm2). A1 and A2: The cells treated with pure gold nanorods; A3 and A4: The cells are not affected; A5 and A6: NIR light alone. B: Cell viability assessed via calcein staining. B1: No dead cells in the test group with 0.1 µg/mL of RGD-dGNRs. B2: No dead cells in the test group with 5 µg/mL of RGD-dGNRs. B3: Cell death and disappearance within the spot in the test group with 100 µg/mL of RGD-dGNRs. Reprinted with permission from [24], Li Z, Huang P, Zhang X, et al. RGD-conjugated dendrimer-modified gold nanorods for in vivo tumor targeting and photothermal therapy. Mol Pharm 2010; 7: 94-104.

Mentions: They also tested the viability of the cells at 110 mW laser irradiation for 4 min (Figure 10 A). The amount of destroyed cells increased as the amount of RGD-dGNR nanoprobes in the medium increased. When the concentration of the RGD-dGNR nanoprobes reached 100 µg/mL, all the cancer cells within the laser spots were killed as shown in Figure 10B. The optimal photothermal therapeutic concentration was 100 µg/mL for in vitro cancer cells.


Functionalized gold nanorods for tumor imaging and targeted therapy.

Gui C, Cui DX - Cancer Biol Med (2012)

A: The cells treated with G4.0-NR-RGD conjugation start to be injured at 70mW (9 W/cm2) and are obviously injured at 110mW (14 W/cm2). A1 and A2: The cells treated with pure gold nanorods; A3 and A4: The cells are not affected; A5 and A6: NIR light alone. B: Cell viability assessed via calcein staining. B1: No dead cells in the test group with 0.1 µg/mL of RGD-dGNRs. B2: No dead cells in the test group with 5 µg/mL of RGD-dGNRs. B3: Cell death and disappearance within the spot in the test group with 100 µg/mL of RGD-dGNRs. Reprinted with permission from [24], Li Z, Huang P, Zhang X, et al. RGD-conjugated dendrimer-modified gold nanorods for in vivo tumor targeting and photothermal therapy. Mol Pharm 2010; 7: 94-104.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3643678&req=5

f10: A: The cells treated with G4.0-NR-RGD conjugation start to be injured at 70mW (9 W/cm2) and are obviously injured at 110mW (14 W/cm2). A1 and A2: The cells treated with pure gold nanorods; A3 and A4: The cells are not affected; A5 and A6: NIR light alone. B: Cell viability assessed via calcein staining. B1: No dead cells in the test group with 0.1 µg/mL of RGD-dGNRs. B2: No dead cells in the test group with 5 µg/mL of RGD-dGNRs. B3: Cell death and disappearance within the spot in the test group with 100 µg/mL of RGD-dGNRs. Reprinted with permission from [24], Li Z, Huang P, Zhang X, et al. RGD-conjugated dendrimer-modified gold nanorods for in vivo tumor targeting and photothermal therapy. Mol Pharm 2010; 7: 94-104.
Mentions: They also tested the viability of the cells at 110 mW laser irradiation for 4 min (Figure 10 A). The amount of destroyed cells increased as the amount of RGD-dGNR nanoprobes in the medium increased. When the concentration of the RGD-dGNR nanoprobes reached 100 µg/mL, all the cancer cells within the laser spots were killed as shown in Figure 10B. The optimal photothermal therapeutic concentration was 100 µg/mL for in vitro cancer cells.

Bottom Line: Gold nanorods, as an emerging noble metal nanomaterial with unique properties, have become the new exciting focus of theoretical and experimental studies in the past few years.The structure and function of gold nanorods, especially their biocompatibility, optical property, and photothermal effects, have been attracting more and more attention.We also explore other prospective applications and discuss the corresponding concepts, issues, approaches, and challenges, with the aim of stimulating broader interest in gold nanorod-based nanotechnology and improving its practical application.

View Article: PubMed Central - PubMed

Affiliation: Department of Bio-Nano Science and Engineering, Key Laboratory for Thin Film and Microfabrication of the Ministry of Education, Institute of Micro-Nano Science and Technology, Shanghai Jiaotong University, Shanghai 200240, China.

ABSTRACT
Gold nanorods, as an emerging noble metal nanomaterial with unique properties, have become the new exciting focus of theoretical and experimental studies in the past few years. The structure and function of gold nanorods, especially their biocompatibility, optical property, and photothermal effects, have been attracting more and more attention. Gold nanorods exhibit great potential in applications such as tumor molecular imaging and photothermal therapy. In this article, we review some of the main advances made over the past few years in the application of gold nanorods in surface functionalization, molecular imaging, and photothermal therapy. We also explore other prospective applications and discuss the corresponding concepts, issues, approaches, and challenges, with the aim of stimulating broader interest in gold nanorod-based nanotechnology and improving its practical application.

No MeSH data available.


Related in: MedlinePlus