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Functionalized gold nanorods for tumor imaging and targeted therapy.

Gui C, Cui DX - Cancer Biol Med (2012)

Bottom Line: Gold nanorods, as an emerging noble metal nanomaterial with unique properties, have become the new exciting focus of theoretical and experimental studies in the past few years.The structure and function of gold nanorods, especially their biocompatibility, optical property, and photothermal effects, have been attracting more and more attention.We also explore other prospective applications and discuss the corresponding concepts, issues, approaches, and challenges, with the aim of stimulating broader interest in gold nanorod-based nanotechnology and improving its practical application.

View Article: PubMed Central - PubMed

Affiliation: Department of Bio-Nano Science and Engineering, Key Laboratory for Thin Film and Microfabrication of the Ministry of Education, Institute of Micro-Nano Science and Technology, Shanghai Jiaotong University, Shanghai 200240, China.

ABSTRACT
Gold nanorods, as an emerging noble metal nanomaterial with unique properties, have become the new exciting focus of theoretical and experimental studies in the past few years. The structure and function of gold nanorods, especially their biocompatibility, optical property, and photothermal effects, have been attracting more and more attention. Gold nanorods exhibit great potential in applications such as tumor molecular imaging and photothermal therapy. In this article, we review some of the main advances made over the past few years in the application of gold nanorods in surface functionalization, molecular imaging, and photothermal therapy. We also explore other prospective applications and discuss the corresponding concepts, issues, approaches, and challenges, with the aim of stimulating broader interest in gold nanorod-based nanotechnology and improving its practical application.

No MeSH data available.


Related in: MedlinePlus

A: Potential of gold nanorods with an aspect ratio of 3.0 in a DNA solution with pH from 5.0 to 11.0. B: Agarose electrophoresis mobility retardation assays of DNA-nanorod complexes: (lane 1) 5M. DNA: (lanes 2-7) nanorod-DNA complexes with [DNA] of 2.5, 5.0, 7.5, 10.0, 12.5, and 15.0 íM, respectively. C: Cartoon illustrating “zipping”: the formation of the bilayer of CTAB on the nanorod surface and the complexation between nanorods and DNA. Reprinted with permission from [23], Pan B, Cui D, Ozkan C, et al. DNA-templated ordered array of gold nanorods in one and two dimensions. J Phys Chem C 2007; 111: 12572-12576.
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f1: A: Potential of gold nanorods with an aspect ratio of 3.0 in a DNA solution with pH from 5.0 to 11.0. B: Agarose electrophoresis mobility retardation assays of DNA-nanorod complexes: (lane 1) 5M. DNA: (lanes 2-7) nanorod-DNA complexes with [DNA] of 2.5, 5.0, 7.5, 10.0, 12.5, and 15.0 íM, respectively. C: Cartoon illustrating “zipping”: the formation of the bilayer of CTAB on the nanorod surface and the complexation between nanorods and DNA. Reprinted with permission from [23], Pan B, Cui D, Ozkan C, et al. DNA-templated ordered array of gold nanorods in one and two dimensions. J Phys Chem C 2007; 111: 12572-12576.

Mentions: Pan et al.[23] utilized DNA as templates to allow the self-assembly of gold nanorods. Researchers found that GNRs could assemble into one- and two-dimensional structures under suitable conditions, such as appropriate aspect ratio and DNA concentration. The researchers also explained rod–rod self-assembly at different DNA concentrations by the ζ potential. In Figure 1A, the ζ potential is decreased by increasing DNA template concentration, indicating the existence of electrostatic interaction between the positively charged nanorod surface and the negatively charged DNA surface. The mobility of the complexes was completely retarded, indicating that the electrostatic attraction between the CTAB on the nanorods and the negatively charged DNA was extremely strong that DNA mobility was retarded in the sample wells (Figure 1B). Ternary DNA-CTAB-nanorod complexes were formed when the CTAB-coated gold nanorods were mixed directly with DNA (Figure 1C). The nanorod-DNA complexes were fully assembled by the electrostatic interaction between CTAB and DNA. These well-ordered, immobilized gold nanorods can be used in various applications such as optical and electronic devices, biosensors, and catalysis.


Functionalized gold nanorods for tumor imaging and targeted therapy.

Gui C, Cui DX - Cancer Biol Med (2012)

A: Potential of gold nanorods with an aspect ratio of 3.0 in a DNA solution with pH from 5.0 to 11.0. B: Agarose electrophoresis mobility retardation assays of DNA-nanorod complexes: (lane 1) 5M. DNA: (lanes 2-7) nanorod-DNA complexes with [DNA] of 2.5, 5.0, 7.5, 10.0, 12.5, and 15.0 íM, respectively. C: Cartoon illustrating “zipping”: the formation of the bilayer of CTAB on the nanorod surface and the complexation between nanorods and DNA. Reprinted with permission from [23], Pan B, Cui D, Ozkan C, et al. DNA-templated ordered array of gold nanorods in one and two dimensions. J Phys Chem C 2007; 111: 12572-12576.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3643678&req=5

f1: A: Potential of gold nanorods with an aspect ratio of 3.0 in a DNA solution with pH from 5.0 to 11.0. B: Agarose electrophoresis mobility retardation assays of DNA-nanorod complexes: (lane 1) 5M. DNA: (lanes 2-7) nanorod-DNA complexes with [DNA] of 2.5, 5.0, 7.5, 10.0, 12.5, and 15.0 íM, respectively. C: Cartoon illustrating “zipping”: the formation of the bilayer of CTAB on the nanorod surface and the complexation between nanorods and DNA. Reprinted with permission from [23], Pan B, Cui D, Ozkan C, et al. DNA-templated ordered array of gold nanorods in one and two dimensions. J Phys Chem C 2007; 111: 12572-12576.
Mentions: Pan et al.[23] utilized DNA as templates to allow the self-assembly of gold nanorods. Researchers found that GNRs could assemble into one- and two-dimensional structures under suitable conditions, such as appropriate aspect ratio and DNA concentration. The researchers also explained rod–rod self-assembly at different DNA concentrations by the ζ potential. In Figure 1A, the ζ potential is decreased by increasing DNA template concentration, indicating the existence of electrostatic interaction between the positively charged nanorod surface and the negatively charged DNA surface. The mobility of the complexes was completely retarded, indicating that the electrostatic attraction between the CTAB on the nanorods and the negatively charged DNA was extremely strong that DNA mobility was retarded in the sample wells (Figure 1B). Ternary DNA-CTAB-nanorod complexes were formed when the CTAB-coated gold nanorods were mixed directly with DNA (Figure 1C). The nanorod-DNA complexes were fully assembled by the electrostatic interaction between CTAB and DNA. These well-ordered, immobilized gold nanorods can be used in various applications such as optical and electronic devices, biosensors, and catalysis.

Bottom Line: Gold nanorods, as an emerging noble metal nanomaterial with unique properties, have become the new exciting focus of theoretical and experimental studies in the past few years.The structure and function of gold nanorods, especially their biocompatibility, optical property, and photothermal effects, have been attracting more and more attention.We also explore other prospective applications and discuss the corresponding concepts, issues, approaches, and challenges, with the aim of stimulating broader interest in gold nanorod-based nanotechnology and improving its practical application.

View Article: PubMed Central - PubMed

Affiliation: Department of Bio-Nano Science and Engineering, Key Laboratory for Thin Film and Microfabrication of the Ministry of Education, Institute of Micro-Nano Science and Technology, Shanghai Jiaotong University, Shanghai 200240, China.

ABSTRACT
Gold nanorods, as an emerging noble metal nanomaterial with unique properties, have become the new exciting focus of theoretical and experimental studies in the past few years. The structure and function of gold nanorods, especially their biocompatibility, optical property, and photothermal effects, have been attracting more and more attention. Gold nanorods exhibit great potential in applications such as tumor molecular imaging and photothermal therapy. In this article, we review some of the main advances made over the past few years in the application of gold nanorods in surface functionalization, molecular imaging, and photothermal therapy. We also explore other prospective applications and discuss the corresponding concepts, issues, approaches, and challenges, with the aim of stimulating broader interest in gold nanorod-based nanotechnology and improving its practical application.

No MeSH data available.


Related in: MedlinePlus