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In vivo Anticancer Activities of Benzophenone Semicarbazone against Ehrlich Ascites Carcinoma Cells in Swiss Albino Mice.

Islam K, Ali SM, Jesmin M, Khanam JA - Cancer Biol Med (2012)

Bottom Line: The results showed that BSC has a positive effect against EAC cells.An assessment was conducted by comparing these results with those obtained using the standard drug bleomycin.The BSC compound can be considered as a potent anticancer agent.

View Article: PubMed Central - PubMed

Affiliation: Department of Applied Chemistry and Chemical Engineering, University of Rajshahi, Rajshahi 6205, Bangladesh.

ABSTRACT

Objective: Benzophenone semicarbazone (BSC) was synthesized and characterized to identify compounds with anticancer activities.

Methods: Anticancer activities were studied against Ehrlich Ascites Carcinoma (EAC) cells in Swiss albino mice by monitoring parameters such as tumor weight measurement, survival time of tumor bearing mice, tumor cell growth inhibition, and so on. Some hematological parameters, such as red blood cells, white blood cells, and hemoglobin content, were also measured.

Results: The results showed that BSC has a positive effect against EAC cells. An assessment was conducted by comparing these results with those obtained using the standard drug bleomycin.

Conclusions: The BSC compound can be considered as a potent anticancer agent.

No MeSH data available.


Related in: MedlinePlus

Effect of BSC on the hemoglobin content of EAC-bearing mice on days 5, 10, 15, and 25. Data are expressed as the mean of the results from 4 mice. Treatment was continued for 10 consecutive days.
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f4: Effect of BSC on the hemoglobin content of EAC-bearing mice on days 5, 10, 15, and 25. Data are expressed as the mean of the results from 4 mice. Treatment was continued for 10 consecutive days.

Mentions: The effects of the test compound on the hematological parameters of the tumor-bearing mice are shown in Figures 2, 3, 4. The hematological parameters varied from their normal values along with tumor growth. The hemoglobin content and RBC counts decreased, whereas the WBC counts increased after the inoculation of EAC cells. After treatment with the test compound at the previously specified doses, the parameters were restored moderately only at a high BSC dose (25 mg/kg).


In vivo Anticancer Activities of Benzophenone Semicarbazone against Ehrlich Ascites Carcinoma Cells in Swiss Albino Mice.

Islam K, Ali SM, Jesmin M, Khanam JA - Cancer Biol Med (2012)

Effect of BSC on the hemoglobin content of EAC-bearing mice on days 5, 10, 15, and 25. Data are expressed as the mean of the results from 4 mice. Treatment was continued for 10 consecutive days.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3643672&req=5

f4: Effect of BSC on the hemoglobin content of EAC-bearing mice on days 5, 10, 15, and 25. Data are expressed as the mean of the results from 4 mice. Treatment was continued for 10 consecutive days.
Mentions: The effects of the test compound on the hematological parameters of the tumor-bearing mice are shown in Figures 2, 3, 4. The hematological parameters varied from their normal values along with tumor growth. The hemoglobin content and RBC counts decreased, whereas the WBC counts increased after the inoculation of EAC cells. After treatment with the test compound at the previously specified doses, the parameters were restored moderately only at a high BSC dose (25 mg/kg).

Bottom Line: The results showed that BSC has a positive effect against EAC cells.An assessment was conducted by comparing these results with those obtained using the standard drug bleomycin.The BSC compound can be considered as a potent anticancer agent.

View Article: PubMed Central - PubMed

Affiliation: Department of Applied Chemistry and Chemical Engineering, University of Rajshahi, Rajshahi 6205, Bangladesh.

ABSTRACT

Objective: Benzophenone semicarbazone (BSC) was synthesized and characterized to identify compounds with anticancer activities.

Methods: Anticancer activities were studied against Ehrlich Ascites Carcinoma (EAC) cells in Swiss albino mice by monitoring parameters such as tumor weight measurement, survival time of tumor bearing mice, tumor cell growth inhibition, and so on. Some hematological parameters, such as red blood cells, white blood cells, and hemoglobin content, were also measured.

Results: The results showed that BSC has a positive effect against EAC cells. An assessment was conducted by comparing these results with those obtained using the standard drug bleomycin.

Conclusions: The BSC compound can be considered as a potent anticancer agent.

No MeSH data available.


Related in: MedlinePlus