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Hepatic Resection is Safe for Metachronous Hepatic Metastases from Ovarian Cancer.

Niu GC, Shen CM, Cui W, Li Q - Cancer Biol Med (2012)

Bottom Line: The result was a median survival of 39 months and 5-year overall survival rate of 30%.Furthermore, the surgery result (P=0.004) remained significant for prognosis in multivariate analysis.For patients with OCLM, HR is safe and may provide a significant survival benefit compared with medical therapy alone.

View Article: PubMed Central - PubMed

Affiliation: Department of Hepatobiliary Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.

ABSTRACT

Objective: To explore the efficacy of hepatic resection (HR) in a relatively unselected group of patients with ovarian cancer liver metastases (OCLM).

Methods: A study was conducted between September 2000 and September 2011 on 60 ovarian cancer patients with hepatic metastases (24 solitary and 36 multiple), 40 of whom had extrahepatic metastases. HR was done in all patients provided that curative hepatic resection was feasible, and extrahepatic disease was controlled with medical and/or surgical therapy.

Results: Most patients (n=54; 90.0%) had a negative hepatic margin (R0), whereas 6 patients (10.0%) had microscopic disease at the margin (R1). The prognostic value of each study variable was assessed using log rank tests for univariate analysis and Cox proportional hazard models for multivariate analysis. The result was a median survival of 39 months and 5-year overall survival rate of 30%. Univariate analysis showed that surgery result (P=0.001), disease free interval (P=0.018) and the number of hepatic lesions (P=0.018) were significantly related to survival. Furthermore, the surgery result (P=0.004) remained significant for prognosis in multivariate analysis.

Conclusions: For patients with OCLM, HR is safe and may provide a significant survival benefit compared with medical therapy alone. A long interval time, the number of hepatic lesions, and surgery results are key prognostic factors. Favorable outcomes can be achieved even in patients with medically controlled or surgically resectable extrahepatic disease, indicating that surgery should be considered more frequently in the multidisciplinary care of patients with OCLM.

No MeSH data available.


Related in: MedlinePlus

Overall cumulative survival rate for patients with OCLM undergoing resection based on the number of hepatic lesions. Overall cumulative survival rate was significantly worse in the multiple group than in the single group (P=0.018).
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f2: Overall cumulative survival rate for patients with OCLM undergoing resection based on the number of hepatic lesions. Overall cumulative survival rate was significantly worse in the multiple group than in the single group (P=0.018).

Mentions: When calculated from the time of surgery, the median overall survival was 39 months (range was from 5 to 79), with a 5-year survival rate of 39%. In univariate analysis, surgery result (P=0.039, Figure 1), number of lesions (P=0.018, Figure 2), and disease-free interval (P=0.018, Figure 3) were the only factors significantly associated with survival. In the multivariate analysis, surgery result (P=0.004) also remained significant for prognosis (Table 3).


Hepatic Resection is Safe for Metachronous Hepatic Metastases from Ovarian Cancer.

Niu GC, Shen CM, Cui W, Li Q - Cancer Biol Med (2012)

Overall cumulative survival rate for patients with OCLM undergoing resection based on the number of hepatic lesions. Overall cumulative survival rate was significantly worse in the multiple group than in the single group (P=0.018).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3643668&req=5

f2: Overall cumulative survival rate for patients with OCLM undergoing resection based on the number of hepatic lesions. Overall cumulative survival rate was significantly worse in the multiple group than in the single group (P=0.018).
Mentions: When calculated from the time of surgery, the median overall survival was 39 months (range was from 5 to 79), with a 5-year survival rate of 39%. In univariate analysis, surgery result (P=0.039, Figure 1), number of lesions (P=0.018, Figure 2), and disease-free interval (P=0.018, Figure 3) were the only factors significantly associated with survival. In the multivariate analysis, surgery result (P=0.004) also remained significant for prognosis (Table 3).

Bottom Line: The result was a median survival of 39 months and 5-year overall survival rate of 30%.Furthermore, the surgery result (P=0.004) remained significant for prognosis in multivariate analysis.For patients with OCLM, HR is safe and may provide a significant survival benefit compared with medical therapy alone.

View Article: PubMed Central - PubMed

Affiliation: Department of Hepatobiliary Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.

ABSTRACT

Objective: To explore the efficacy of hepatic resection (HR) in a relatively unselected group of patients with ovarian cancer liver metastases (OCLM).

Methods: A study was conducted between September 2000 and September 2011 on 60 ovarian cancer patients with hepatic metastases (24 solitary and 36 multiple), 40 of whom had extrahepatic metastases. HR was done in all patients provided that curative hepatic resection was feasible, and extrahepatic disease was controlled with medical and/or surgical therapy.

Results: Most patients (n=54; 90.0%) had a negative hepatic margin (R0), whereas 6 patients (10.0%) had microscopic disease at the margin (R1). The prognostic value of each study variable was assessed using log rank tests for univariate analysis and Cox proportional hazard models for multivariate analysis. The result was a median survival of 39 months and 5-year overall survival rate of 30%. Univariate analysis showed that surgery result (P=0.001), disease free interval (P=0.018) and the number of hepatic lesions (P=0.018) were significantly related to survival. Furthermore, the surgery result (P=0.004) remained significant for prognosis in multivariate analysis.

Conclusions: For patients with OCLM, HR is safe and may provide a significant survival benefit compared with medical therapy alone. A long interval time, the number of hepatic lesions, and surgery results are key prognostic factors. Favorable outcomes can be achieved even in patients with medically controlled or surgically resectable extrahepatic disease, indicating that surgery should be considered more frequently in the multidisciplinary care of patients with OCLM.

No MeSH data available.


Related in: MedlinePlus