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Clinical Significance of CENP-H Expression in Uterine Cervical Cancer.

Weng MY, Li L, Hong SJ, Feng SY - Cancer Biol Med (2012)

Bottom Line: The analysis of Cox proportional hazards regression model suggested that CENP-H expression (P=0.002) and tumor stage (P=0.001) were independent prognostic markers for the survival of UCC patients.The survival analysis showed that the survival rate was significantly lower in patients with high expression of CENP-H than in those with low expression of CENP-H (P=0.001).CENP-H is likely to be a valuable marker for carcinogenesis and progression of UCC.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou 510120, China.

ABSTRACT

Objective: This work aims to investigate the expression pattern and clinicopathologic significance of centromere protein H (CENP-H) in uterine cervical cancer (UCC).

Methods: The level of CENP-H expression in the paraffin sections of 62 UCC cases was determined by the SP immunohistochemical method, with complete clinicopathologic data in all cases. Statistical analysis was conducted to evaluate the prognostic and diagnostic significance of CENP-H using SPSS13.0 software package.

Results: Immunohistochemical assay showed strong CENP-H expression in 61.29% (38/62) of the paraffin-embedded cervical cancer tissues. Statistical analysis revealed a strong correlation between the CENP-H expression and the clinical classification (P=0.038) of the cervical carcinoma. The expression increased with rise of the stages. The analysis of Cox proportional hazards regression model suggested that CENP-H expression (P=0.002) and tumor stage (P=0.001) were independent prognostic markers for the survival of UCC patients. The survival analysis showed that the survival rate was significantly lower in patients with high expression of CENP-H than in those with low expression of CENP-H (P=0.001).

Conclusions: CENP-H is likely to be a valuable marker for carcinogenesis and progression of UCC. It might be used as the important diagnostic and prognostic marker for cervical carcinoma patients, especially for those at early stage.

No MeSH data available.


Related in: MedlinePlus

Comparison of the survival rates between the group with high CENP-H expression and that with low CENP-H expression in the 62 UCC patients.
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f2: Comparison of the survival rates between the group with high CENP-H expression and that with low CENP-H expression in the 62 UCC patients.

Mentions: Kaplan-Meier analysis revealed that there were significant differences in the survival time between the patients in the group with high CENP-H expression and those with low CENP-H expression (P=0.002). The median survival was 17 months for the patients with high CENP-H expression and 34 months for those with low CENP-H expression (Figure 2).


Clinical Significance of CENP-H Expression in Uterine Cervical Cancer.

Weng MY, Li L, Hong SJ, Feng SY - Cancer Biol Med (2012)

Comparison of the survival rates between the group with high CENP-H expression and that with low CENP-H expression in the 62 UCC patients.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3643666&req=5

f2: Comparison of the survival rates between the group with high CENP-H expression and that with low CENP-H expression in the 62 UCC patients.
Mentions: Kaplan-Meier analysis revealed that there were significant differences in the survival time between the patients in the group with high CENP-H expression and those with low CENP-H expression (P=0.002). The median survival was 17 months for the patients with high CENP-H expression and 34 months for those with low CENP-H expression (Figure 2).

Bottom Line: The analysis of Cox proportional hazards regression model suggested that CENP-H expression (P=0.002) and tumor stage (P=0.001) were independent prognostic markers for the survival of UCC patients.The survival analysis showed that the survival rate was significantly lower in patients with high expression of CENP-H than in those with low expression of CENP-H (P=0.001).CENP-H is likely to be a valuable marker for carcinogenesis and progression of UCC.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou 510120, China.

ABSTRACT

Objective: This work aims to investigate the expression pattern and clinicopathologic significance of centromere protein H (CENP-H) in uterine cervical cancer (UCC).

Methods: The level of CENP-H expression in the paraffin sections of 62 UCC cases was determined by the SP immunohistochemical method, with complete clinicopathologic data in all cases. Statistical analysis was conducted to evaluate the prognostic and diagnostic significance of CENP-H using SPSS13.0 software package.

Results: Immunohistochemical assay showed strong CENP-H expression in 61.29% (38/62) of the paraffin-embedded cervical cancer tissues. Statistical analysis revealed a strong correlation between the CENP-H expression and the clinical classification (P=0.038) of the cervical carcinoma. The expression increased with rise of the stages. The analysis of Cox proportional hazards regression model suggested that CENP-H expression (P=0.002) and tumor stage (P=0.001) were independent prognostic markers for the survival of UCC patients. The survival analysis showed that the survival rate was significantly lower in patients with high expression of CENP-H than in those with low expression of CENP-H (P=0.001).

Conclusions: CENP-H is likely to be a valuable marker for carcinogenesis and progression of UCC. It might be used as the important diagnostic and prognostic marker for cervical carcinoma patients, especially for those at early stage.

No MeSH data available.


Related in: MedlinePlus