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Clinical Significance of CENP-H Expression in Uterine Cervical Cancer.

Weng MY, Li L, Hong SJ, Feng SY - Cancer Biol Med (2012)

Bottom Line: The analysis of Cox proportional hazards regression model suggested that CENP-H expression (P=0.002) and tumor stage (P=0.001) were independent prognostic markers for the survival of UCC patients.The survival analysis showed that the survival rate was significantly lower in patients with high expression of CENP-H than in those with low expression of CENP-H (P=0.001).CENP-H is likely to be a valuable marker for carcinogenesis and progression of UCC.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou 510120, China.

ABSTRACT

Objective: This work aims to investigate the expression pattern and clinicopathologic significance of centromere protein H (CENP-H) in uterine cervical cancer (UCC).

Methods: The level of CENP-H expression in the paraffin sections of 62 UCC cases was determined by the SP immunohistochemical method, with complete clinicopathologic data in all cases. Statistical analysis was conducted to evaluate the prognostic and diagnostic significance of CENP-H using SPSS13.0 software package.

Results: Immunohistochemical assay showed strong CENP-H expression in 61.29% (38/62) of the paraffin-embedded cervical cancer tissues. Statistical analysis revealed a strong correlation between the CENP-H expression and the clinical classification (P=0.038) of the cervical carcinoma. The expression increased with rise of the stages. The analysis of Cox proportional hazards regression model suggested that CENP-H expression (P=0.002) and tumor stage (P=0.001) were independent prognostic markers for the survival of UCC patients. The survival analysis showed that the survival rate was significantly lower in patients with high expression of CENP-H than in those with low expression of CENP-H (P=0.001).

Conclusions: CENP-H is likely to be a valuable marker for carcinogenesis and progression of UCC. It might be used as the important diagnostic and prognostic marker for cervical carcinoma patients, especially for those at early stage.

No MeSH data available.


Related in: MedlinePlus

Immunohistochemical staining for CENP-H expression in uterine cervical cancer and paraneoplastic tissues. A: Absence of CENP-H expression in paraneoplastic tissues; B: Low expression of CENP-H in uterine cervical cancer; C: High expression of CENP-H in uterine cervical cancer (200 ×).
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f1: Immunohistochemical staining for CENP-H expression in uterine cervical cancer and paraneoplastic tissues. A: Absence of CENP-H expression in paraneoplastic tissues; B: Low expression of CENP-H in uterine cervical cancer; C: High expression of CENP-H in uterine cervical cancer (200 ×).

Mentions: CENP-H expressed in the nucleus of UCC cells. However, CENP-H staining of the cell nucleus was not found in the paraneoplastic epithelial cells (Figure 1). In the 62 UCC specimens, the rate of high CENP-H expression was 61.29% (38/62).


Clinical Significance of CENP-H Expression in Uterine Cervical Cancer.

Weng MY, Li L, Hong SJ, Feng SY - Cancer Biol Med (2012)

Immunohistochemical staining for CENP-H expression in uterine cervical cancer and paraneoplastic tissues. A: Absence of CENP-H expression in paraneoplastic tissues; B: Low expression of CENP-H in uterine cervical cancer; C: High expression of CENP-H in uterine cervical cancer (200 ×).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3643666&req=5

f1: Immunohistochemical staining for CENP-H expression in uterine cervical cancer and paraneoplastic tissues. A: Absence of CENP-H expression in paraneoplastic tissues; B: Low expression of CENP-H in uterine cervical cancer; C: High expression of CENP-H in uterine cervical cancer (200 ×).
Mentions: CENP-H expressed in the nucleus of UCC cells. However, CENP-H staining of the cell nucleus was not found in the paraneoplastic epithelial cells (Figure 1). In the 62 UCC specimens, the rate of high CENP-H expression was 61.29% (38/62).

Bottom Line: The analysis of Cox proportional hazards regression model suggested that CENP-H expression (P=0.002) and tumor stage (P=0.001) were independent prognostic markers for the survival of UCC patients.The survival analysis showed that the survival rate was significantly lower in patients with high expression of CENP-H than in those with low expression of CENP-H (P=0.001).CENP-H is likely to be a valuable marker for carcinogenesis and progression of UCC.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou 510120, China.

ABSTRACT

Objective: This work aims to investigate the expression pattern and clinicopathologic significance of centromere protein H (CENP-H) in uterine cervical cancer (UCC).

Methods: The level of CENP-H expression in the paraffin sections of 62 UCC cases was determined by the SP immunohistochemical method, with complete clinicopathologic data in all cases. Statistical analysis was conducted to evaluate the prognostic and diagnostic significance of CENP-H using SPSS13.0 software package.

Results: Immunohistochemical assay showed strong CENP-H expression in 61.29% (38/62) of the paraffin-embedded cervical cancer tissues. Statistical analysis revealed a strong correlation between the CENP-H expression and the clinical classification (P=0.038) of the cervical carcinoma. The expression increased with rise of the stages. The analysis of Cox proportional hazards regression model suggested that CENP-H expression (P=0.002) and tumor stage (P=0.001) were independent prognostic markers for the survival of UCC patients. The survival analysis showed that the survival rate was significantly lower in patients with high expression of CENP-H than in those with low expression of CENP-H (P=0.001).

Conclusions: CENP-H is likely to be a valuable marker for carcinogenesis and progression of UCC. It might be used as the important diagnostic and prognostic marker for cervical carcinoma patients, especially for those at early stage.

No MeSH data available.


Related in: MedlinePlus