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Quantum dots for cancer research: current status, remaining issues, and future perspectives.

Fang M, Peng CW, Pang DW, Li Y - Cancer Biol Med (2012)

Bottom Line: Cancer is a major threat to public health in the 21st century because it is one of the leading causes of death worldwide.The mechanisms of carcinogenesis, cancer invasion, and metastasis remain unclear.Thus, the development of a novel approach for cancer detection is urgent, and real-time monitoring is crucial in revealing its underlying biological mechanisms.

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors & Hubei Cancer Clinical Study Center, Wuhan 430071, China.

ABSTRACT
Cancer is a major threat to public health in the 21st century because it is one of the leading causes of death worldwide. The mechanisms of carcinogenesis, cancer invasion, and metastasis remain unclear. Thus, the development of a novel approach for cancer detection is urgent, and real-time monitoring is crucial in revealing its underlying biological mechanisms. With the optical and chemical advantages of quantum dots (QDs), QD-based nanotechnology is helpful in constructing a biomedical imaging platform for cancer behavior study. This review mainly focuses on the application of QD-based nanotechnology in cancer cell imaging and tumor microenvironment studies both in vivo and in vitro, as well as the remaining issues and future perspectives.

No MeSH data available.


Related in: MedlinePlus

Double-color imaging was used in BC over different levels of HER2. A: Benign breast tumor, no HER2 expression, and intact ECM (Red arrow). B: BC with HER2 (+) (Red arrow), ECM becomes unsmooth and thin (Yellow arrows). C: HER2 (2+) and moderate green fluorescence (Red arrow). ECM becomes significantly degraded (Yellow arrow). D: HER2 (3+), strong green fluorescence (Red arrow) and complete ECM degradation (Yellow arrow). (Magnification: ×, scale bar =20 µm). Reproduced with permission from [69].
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f4: Double-color imaging was used in BC over different levels of HER2. A: Benign breast tumor, no HER2 expression, and intact ECM (Red arrow). B: BC with HER2 (+) (Red arrow), ECM becomes unsmooth and thin (Yellow arrows). C: HER2 (2+) and moderate green fluorescence (Red arrow). ECM becomes significantly degraded (Yellow arrow). D: HER2 (3+), strong green fluorescence (Red arrow) and complete ECM degradation (Yellow arrow). (Magnification: ×, scale bar =20 µm). Reproduced with permission from [69].

Mentions: Our group recently confirmed the benefit of QD-based multiplexed imaging and spectrum analysis technology to study the co-evolution of cancer cells and tumor stroma by type IV collagen, tumor angiogenesis, macrophage infiltration, and tissue destructive proteolytic enzyme MMP9[107,108], which revealed the related molecular features of tumor microenvironment during cancer invasion[108] (Figure 3). Four invasive patterns with distinctive cancer cell-stroma interactions were identified, namely, washing, amoeba-like, polar, and linear patterns. Another research on QDbased doublecolor imaging of HER2 on BC cells and the type IV collagen in the ECM also showcase the dynamic processes of BC invasion (Figure 4)[69].


Quantum dots for cancer research: current status, remaining issues, and future perspectives.

Fang M, Peng CW, Pang DW, Li Y - Cancer Biol Med (2012)

Double-color imaging was used in BC over different levels of HER2. A: Benign breast tumor, no HER2 expression, and intact ECM (Red arrow). B: BC with HER2 (+) (Red arrow), ECM becomes unsmooth and thin (Yellow arrows). C: HER2 (2+) and moderate green fluorescence (Red arrow). ECM becomes significantly degraded (Yellow arrow). D: HER2 (3+), strong green fluorescence (Red arrow) and complete ECM degradation (Yellow arrow). (Magnification: ×, scale bar =20 µm). Reproduced with permission from [69].
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3643664&req=5

f4: Double-color imaging was used in BC over different levels of HER2. A: Benign breast tumor, no HER2 expression, and intact ECM (Red arrow). B: BC with HER2 (+) (Red arrow), ECM becomes unsmooth and thin (Yellow arrows). C: HER2 (2+) and moderate green fluorescence (Red arrow). ECM becomes significantly degraded (Yellow arrow). D: HER2 (3+), strong green fluorescence (Red arrow) and complete ECM degradation (Yellow arrow). (Magnification: ×, scale bar =20 µm). Reproduced with permission from [69].
Mentions: Our group recently confirmed the benefit of QD-based multiplexed imaging and spectrum analysis technology to study the co-evolution of cancer cells and tumor stroma by type IV collagen, tumor angiogenesis, macrophage infiltration, and tissue destructive proteolytic enzyme MMP9[107,108], which revealed the related molecular features of tumor microenvironment during cancer invasion[108] (Figure 3). Four invasive patterns with distinctive cancer cell-stroma interactions were identified, namely, washing, amoeba-like, polar, and linear patterns. Another research on QDbased doublecolor imaging of HER2 on BC cells and the type IV collagen in the ECM also showcase the dynamic processes of BC invasion (Figure 4)[69].

Bottom Line: Cancer is a major threat to public health in the 21st century because it is one of the leading causes of death worldwide.The mechanisms of carcinogenesis, cancer invasion, and metastasis remain unclear.Thus, the development of a novel approach for cancer detection is urgent, and real-time monitoring is crucial in revealing its underlying biological mechanisms.

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors & Hubei Cancer Clinical Study Center, Wuhan 430071, China.

ABSTRACT
Cancer is a major threat to public health in the 21st century because it is one of the leading causes of death worldwide. The mechanisms of carcinogenesis, cancer invasion, and metastasis remain unclear. Thus, the development of a novel approach for cancer detection is urgent, and real-time monitoring is crucial in revealing its underlying biological mechanisms. With the optical and chemical advantages of quantum dots (QDs), QD-based nanotechnology is helpful in constructing a biomedical imaging platform for cancer behavior study. This review mainly focuses on the application of QD-based nanotechnology in cancer cell imaging and tumor microenvironment studies both in vivo and in vitro, as well as the remaining issues and future perspectives.

No MeSH data available.


Related in: MedlinePlus