Limits...
Quantum dots for cancer research: current status, remaining issues, and future perspectives.

Fang M, Peng CW, Pang DW, Li Y - Cancer Biol Med (2012)

Bottom Line: Cancer is a major threat to public health in the 21st century because it is one of the leading causes of death worldwide.The mechanisms of carcinogenesis, cancer invasion, and metastasis remain unclear.Thus, the development of a novel approach for cancer detection is urgent, and real-time monitoring is crucial in revealing its underlying biological mechanisms.

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors & Hubei Cancer Clinical Study Center, Wuhan 430071, China.

ABSTRACT
Cancer is a major threat to public health in the 21st century because it is one of the leading causes of death worldwide. The mechanisms of carcinogenesis, cancer invasion, and metastasis remain unclear. Thus, the development of a novel approach for cancer detection is urgent, and real-time monitoring is crucial in revealing its underlying biological mechanisms. With the optical and chemical advantages of quantum dots (QDs), QD-based nanotechnology is helpful in constructing a biomedical imaging platform for cancer behavior study. This review mainly focuses on the application of QD-based nanotechnology in cancer cell imaging and tumor microenvironment studies both in vivo and in vitro, as well as the remaining issues and future perspectives.

No MeSH data available.


Related in: MedlinePlus

In vivo targeting and imaging of a lung metastasis model with QD-based nanotechnology. A: The imaging system for living animal models. B: In vivo targeted imaging of the subcutaneous tumor model and site-by-site spectra analysis of the tumor, which showed that the QD-labeled anti-a-fetoprotein monoclonal antibody probes per field were lower at the center than in the periphery of the tumor, indicating that tumor growth was not homogeneous and the peripheral site was more active. C: In vivo targeted imaging of liver cancer lung metastasis models. Reproduced with permission from [53].
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3643664&req=5

f2: In vivo targeting and imaging of a lung metastasis model with QD-based nanotechnology. A: The imaging system for living animal models. B: In vivo targeted imaging of the subcutaneous tumor model and site-by-site spectra analysis of the tumor, which showed that the QD-labeled anti-a-fetoprotein monoclonal antibody probes per field were lower at the center than in the periphery of the tumor, indicating that tumor growth was not homogeneous and the peripheral site was more active. C: In vivo targeted imaging of liver cancer lung metastasis models. Reproduced with permission from [53].

Mentions: In addition, our group developed a standard protocol for in vivo imaging of liver cancer xenograft animal models[98,101-103]. We successfully achieved animal imaging by injecting human hepatocellular carcinoma cell lines (HCCLM6) that overexpress alpha-fetoprotein (AFP) with antiAFP monoclonal antibody and QD-IgG probes. HCCLM6 has increased potential for lung metastasis, so it helps in the construction of a platform for the early monitoring of liver cancer metastasis (Figure 2)[53].


Quantum dots for cancer research: current status, remaining issues, and future perspectives.

Fang M, Peng CW, Pang DW, Li Y - Cancer Biol Med (2012)

In vivo targeting and imaging of a lung metastasis model with QD-based nanotechnology. A: The imaging system for living animal models. B: In vivo targeted imaging of the subcutaneous tumor model and site-by-site spectra analysis of the tumor, which showed that the QD-labeled anti-a-fetoprotein monoclonal antibody probes per field were lower at the center than in the periphery of the tumor, indicating that tumor growth was not homogeneous and the peripheral site was more active. C: In vivo targeted imaging of liver cancer lung metastasis models. Reproduced with permission from [53].
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3643664&req=5

f2: In vivo targeting and imaging of a lung metastasis model with QD-based nanotechnology. A: The imaging system for living animal models. B: In vivo targeted imaging of the subcutaneous tumor model and site-by-site spectra analysis of the tumor, which showed that the QD-labeled anti-a-fetoprotein monoclonal antibody probes per field were lower at the center than in the periphery of the tumor, indicating that tumor growth was not homogeneous and the peripheral site was more active. C: In vivo targeted imaging of liver cancer lung metastasis models. Reproduced with permission from [53].
Mentions: In addition, our group developed a standard protocol for in vivo imaging of liver cancer xenograft animal models[98,101-103]. We successfully achieved animal imaging by injecting human hepatocellular carcinoma cell lines (HCCLM6) that overexpress alpha-fetoprotein (AFP) with antiAFP monoclonal antibody and QD-IgG probes. HCCLM6 has increased potential for lung metastasis, so it helps in the construction of a platform for the early monitoring of liver cancer metastasis (Figure 2)[53].

Bottom Line: Cancer is a major threat to public health in the 21st century because it is one of the leading causes of death worldwide.The mechanisms of carcinogenesis, cancer invasion, and metastasis remain unclear.Thus, the development of a novel approach for cancer detection is urgent, and real-time monitoring is crucial in revealing its underlying biological mechanisms.

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors & Hubei Cancer Clinical Study Center, Wuhan 430071, China.

ABSTRACT
Cancer is a major threat to public health in the 21st century because it is one of the leading causes of death worldwide. The mechanisms of carcinogenesis, cancer invasion, and metastasis remain unclear. Thus, the development of a novel approach for cancer detection is urgent, and real-time monitoring is crucial in revealing its underlying biological mechanisms. With the optical and chemical advantages of quantum dots (QDs), QD-based nanotechnology is helpful in constructing a biomedical imaging platform for cancer behavior study. This review mainly focuses on the application of QD-based nanotechnology in cancer cell imaging and tumor microenvironment studies both in vivo and in vitro, as well as the remaining issues and future perspectives.

No MeSH data available.


Related in: MedlinePlus