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Accessory breast cancer occurring concurrently with bilateral primary invasive breast carcinomas: a report of two cases and literature review.

Hao JY, Yang CC, Liu FF, Yang YL, Li S, Li WD, Li YQ, Lang RG, Fan Y, Paulos E, Zhang XM, Fu L - Cancer Biol Med (2012)

Bottom Line: The development of accessory breast tissue, which is found anywhere along the milk line, is attributed to the failure of milk line remnants to regress during embryogenesis.The second case was a 53-year-old Chinese female with bilateral breast cancer (apocrine carcinoma) accompanied by an accessory breast carcinoma (IDC-NOS) in her right axilla that was also incidentally identified.The patient was surgically treated after three doses of cyclophosphamide epirubicin docetaxel (CET) neoadjuvant chemotherapy, followed by adjuvant chemotherapy of the same regimen.

View Article: PubMed Central - PubMed

Affiliation: Department of Breast Cancer Pathology and Research Laboratory, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Tianjin 300060, China.

ABSTRACT
The development of accessory breast tissue, which is found anywhere along the milk line, is attributed to the failure of milk line remnants to regress during embryogenesis. Primary tumors may arise from any ectopic breast tissue. Accessory breast cancer occurring concurrently with primary invasive breast cancer is extremely rare. Two such cases were reported in this article. One was a 43-year-old Chinese female who exhibited bilateral breast cancer (invasive ductal carcinoma, not otherwise specified, IDC-NOS) and an accessory breast carcinoma (IDC-NOS) incidentally identified in her left axilla. The ectopic breast tissue in her right axilla presented with adenosis. The patient was surgically treated, followed by postoperative docetaxel epirubicin (TE) chemotherapy. The second case was a 53-year-old Chinese female with bilateral breast cancer (apocrine carcinoma) accompanied by an accessory breast carcinoma (IDC-NOS) in her right axilla that was also incidentally identified. The patient was surgically treated after three doses of cyclophosphamide epirubicin docetaxel (CET) neoadjuvant chemotherapy, followed by adjuvant chemotherapy of the same regimen.

No MeSH data available.


Related in: MedlinePlus

The right axillary mass consisted of IDC-NOS (upper right) with chemotherapy reaction II, adjacent to benign ectopic breast tissue (upper left), (H&E stain, ×40).
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f7: The right axillary mass consisted of IDC-NOS (upper right) with chemotherapy reaction II, adjacent to benign ectopic breast tissue (upper left), (H&E stain, ×40).

Mentions: Microscopic examination revealed that the tumors in the right (Figure 5A) and left (Figure 5B) breasts were apocrine carcinoma, with GCDFP-15 protein expression in each tumor (Figures 5C and D). These carcinomas exhibited grade II chemotherapy reaction in the Miller-Payne system[5]. Ductal carcinoma in situ was also noted admixed with and adjacent to the invasive carcinoma in each breast (Figures 6A and B). The tumors spread to 1 of the 17 lymph nodes in the right axilla, and to 6 of the 16 lymph nodes in the left axilla. The right axillary mass consisted of IDC-NOS, with grade II chemotherapy reaction, adjacent to benign ectopic breast tissue (Figure 7). No lymphoid tissue was identified in the mass lesion. The mass was far from the pectoral breast parenchyma.


Accessory breast cancer occurring concurrently with bilateral primary invasive breast carcinomas: a report of two cases and literature review.

Hao JY, Yang CC, Liu FF, Yang YL, Li S, Li WD, Li YQ, Lang RG, Fan Y, Paulos E, Zhang XM, Fu L - Cancer Biol Med (2012)

The right axillary mass consisted of IDC-NOS (upper right) with chemotherapy reaction II, adjacent to benign ectopic breast tissue (upper left), (H&E stain, ×40).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3643663&req=5

f7: The right axillary mass consisted of IDC-NOS (upper right) with chemotherapy reaction II, adjacent to benign ectopic breast tissue (upper left), (H&E stain, ×40).
Mentions: Microscopic examination revealed that the tumors in the right (Figure 5A) and left (Figure 5B) breasts were apocrine carcinoma, with GCDFP-15 protein expression in each tumor (Figures 5C and D). These carcinomas exhibited grade II chemotherapy reaction in the Miller-Payne system[5]. Ductal carcinoma in situ was also noted admixed with and adjacent to the invasive carcinoma in each breast (Figures 6A and B). The tumors spread to 1 of the 17 lymph nodes in the right axilla, and to 6 of the 16 lymph nodes in the left axilla. The right axillary mass consisted of IDC-NOS, with grade II chemotherapy reaction, adjacent to benign ectopic breast tissue (Figure 7). No lymphoid tissue was identified in the mass lesion. The mass was far from the pectoral breast parenchyma.

Bottom Line: The development of accessory breast tissue, which is found anywhere along the milk line, is attributed to the failure of milk line remnants to regress during embryogenesis.The second case was a 53-year-old Chinese female with bilateral breast cancer (apocrine carcinoma) accompanied by an accessory breast carcinoma (IDC-NOS) in her right axilla that was also incidentally identified.The patient was surgically treated after three doses of cyclophosphamide epirubicin docetaxel (CET) neoadjuvant chemotherapy, followed by adjuvant chemotherapy of the same regimen.

View Article: PubMed Central - PubMed

Affiliation: Department of Breast Cancer Pathology and Research Laboratory, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Tianjin 300060, China.

ABSTRACT
The development of accessory breast tissue, which is found anywhere along the milk line, is attributed to the failure of milk line remnants to regress during embryogenesis. Primary tumors may arise from any ectopic breast tissue. Accessory breast cancer occurring concurrently with primary invasive breast cancer is extremely rare. Two such cases were reported in this article. One was a 43-year-old Chinese female who exhibited bilateral breast cancer (invasive ductal carcinoma, not otherwise specified, IDC-NOS) and an accessory breast carcinoma (IDC-NOS) incidentally identified in her left axilla. The ectopic breast tissue in her right axilla presented with adenosis. The patient was surgically treated, followed by postoperative docetaxel epirubicin (TE) chemotherapy. The second case was a 53-year-old Chinese female with bilateral breast cancer (apocrine carcinoma) accompanied by an accessory breast carcinoma (IDC-NOS) in her right axilla that was also incidentally identified. The patient was surgically treated after three doses of cyclophosphamide epirubicin docetaxel (CET) neoadjuvant chemotherapy, followed by adjuvant chemotherapy of the same regimen.

No MeSH data available.


Related in: MedlinePlus