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Accessory breast cancer occurring concurrently with bilateral primary invasive breast carcinomas: a report of two cases and literature review.

Hao JY, Yang CC, Liu FF, Yang YL, Li S, Li WD, Li YQ, Lang RG, Fan Y, Paulos E, Zhang XM, Fu L - Cancer Biol Med (2012)

Bottom Line: The development of accessory breast tissue, which is found anywhere along the milk line, is attributed to the failure of milk line remnants to regress during embryogenesis.The second case was a 53-year-old Chinese female with bilateral breast cancer (apocrine carcinoma) accompanied by an accessory breast carcinoma (IDC-NOS) in her right axilla that was also incidentally identified.The patient was surgically treated after three doses of cyclophosphamide epirubicin docetaxel (CET) neoadjuvant chemotherapy, followed by adjuvant chemotherapy of the same regimen.

View Article: PubMed Central - PubMed

Affiliation: Department of Breast Cancer Pathology and Research Laboratory, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Tianjin 300060, China.

ABSTRACT
The development of accessory breast tissue, which is found anywhere along the milk line, is attributed to the failure of milk line remnants to regress during embryogenesis. Primary tumors may arise from any ectopic breast tissue. Accessory breast cancer occurring concurrently with primary invasive breast cancer is extremely rare. Two such cases were reported in this article. One was a 43-year-old Chinese female who exhibited bilateral breast cancer (invasive ductal carcinoma, not otherwise specified, IDC-NOS) and an accessory breast carcinoma (IDC-NOS) incidentally identified in her left axilla. The ectopic breast tissue in her right axilla presented with adenosis. The patient was surgically treated, followed by postoperative docetaxel epirubicin (TE) chemotherapy. The second case was a 53-year-old Chinese female with bilateral breast cancer (apocrine carcinoma) accompanied by an accessory breast carcinoma (IDC-NOS) in her right axilla that was also incidentally identified. The patient was surgically treated after three doses of cyclophosphamide epirubicin docetaxel (CET) neoadjuvant chemotherapy, followed by adjuvant chemotherapy of the same regimen.

No MeSH data available.


Related in: MedlinePlus

Case one. Mastectomy specimens and the dissection method: right (A) and left (B).
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f1: Case one. Mastectomy specimens and the dissection method: right (A) and left (B).

Mentions: Mastectomy specimens with axillary contents were placed en bloc in formalin for 48 hours, and then dissected. The right mastectomy specimen measured 24 cm × 21 cm × 3 cm (Figure 1A). A mass measuring 1.6 cm × 1.5 cm × 1.2 cm was identified in the upper-inner quadrant, which was 4.5 cm away from the nipple. The cut surface of the tumor showed firm and dark red tissue with irregular boundary. Twelve lymph nodes ranging from 0.2 cm to 2.6 cm in greatest dimension were found in the right axilla. A soft tissue mass measuring 2.7 cm, which didn’t appear to be a lymph node, was also noted on the cut surface. The left mastectomy specimen measured 30 cm × 24 cm × 2 cm (Figure 1B). A 4.5 cm × 3 cm × 2.5 cm mass was located in the 12 o’clock position of the breast, 3 cm away from the nipple. The mass was firm with an irregular boundary on the cut surface. Fourteen lymph nodes ranging from 0.2 cm to 2.5 cm in greatest dimension were identified in the left axillary content. In addition, a 2.5-cm mass was found in the left axilla. This mass was far from the breast parenchyma and the texture of its tissue was different from that of the other lymph nodes on the cut surface.


Accessory breast cancer occurring concurrently with bilateral primary invasive breast carcinomas: a report of two cases and literature review.

Hao JY, Yang CC, Liu FF, Yang YL, Li S, Li WD, Li YQ, Lang RG, Fan Y, Paulos E, Zhang XM, Fu L - Cancer Biol Med (2012)

Case one. Mastectomy specimens and the dissection method: right (A) and left (B).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3643663&req=5

f1: Case one. Mastectomy specimens and the dissection method: right (A) and left (B).
Mentions: Mastectomy specimens with axillary contents were placed en bloc in formalin for 48 hours, and then dissected. The right mastectomy specimen measured 24 cm × 21 cm × 3 cm (Figure 1A). A mass measuring 1.6 cm × 1.5 cm × 1.2 cm was identified in the upper-inner quadrant, which was 4.5 cm away from the nipple. The cut surface of the tumor showed firm and dark red tissue with irregular boundary. Twelve lymph nodes ranging from 0.2 cm to 2.6 cm in greatest dimension were found in the right axilla. A soft tissue mass measuring 2.7 cm, which didn’t appear to be a lymph node, was also noted on the cut surface. The left mastectomy specimen measured 30 cm × 24 cm × 2 cm (Figure 1B). A 4.5 cm × 3 cm × 2.5 cm mass was located in the 12 o’clock position of the breast, 3 cm away from the nipple. The mass was firm with an irregular boundary on the cut surface. Fourteen lymph nodes ranging from 0.2 cm to 2.5 cm in greatest dimension were identified in the left axillary content. In addition, a 2.5-cm mass was found in the left axilla. This mass was far from the breast parenchyma and the texture of its tissue was different from that of the other lymph nodes on the cut surface.

Bottom Line: The development of accessory breast tissue, which is found anywhere along the milk line, is attributed to the failure of milk line remnants to regress during embryogenesis.The second case was a 53-year-old Chinese female with bilateral breast cancer (apocrine carcinoma) accompanied by an accessory breast carcinoma (IDC-NOS) in her right axilla that was also incidentally identified.The patient was surgically treated after three doses of cyclophosphamide epirubicin docetaxel (CET) neoadjuvant chemotherapy, followed by adjuvant chemotherapy of the same regimen.

View Article: PubMed Central - PubMed

Affiliation: Department of Breast Cancer Pathology and Research Laboratory, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Tianjin 300060, China.

ABSTRACT
The development of accessory breast tissue, which is found anywhere along the milk line, is attributed to the failure of milk line remnants to regress during embryogenesis. Primary tumors may arise from any ectopic breast tissue. Accessory breast cancer occurring concurrently with primary invasive breast cancer is extremely rare. Two such cases were reported in this article. One was a 43-year-old Chinese female who exhibited bilateral breast cancer (invasive ductal carcinoma, not otherwise specified, IDC-NOS) and an accessory breast carcinoma (IDC-NOS) incidentally identified in her left axilla. The ectopic breast tissue in her right axilla presented with adenosis. The patient was surgically treated, followed by postoperative docetaxel epirubicin (TE) chemotherapy. The second case was a 53-year-old Chinese female with bilateral breast cancer (apocrine carcinoma) accompanied by an accessory breast carcinoma (IDC-NOS) in her right axilla that was also incidentally identified. The patient was surgically treated after three doses of cyclophosphamide epirubicin docetaxel (CET) neoadjuvant chemotherapy, followed by adjuvant chemotherapy of the same regimen.

No MeSH data available.


Related in: MedlinePlus