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Adult medulloblastoma associated with syringomyelia: a case report.

Wang CC - Cancer Biol Med (2012)

Bottom Line: The association between cerebellar medulloblastoma and syringomyelia is uncommon and only found in pediatric patients.Paroxysmal bradycardia is an uncommon clinical manifestation in posterior fossa tumors and likely to be vagally mediated via brainstem preganglionic cardiac motor neurons.This report introduces the diagnosis and treatment of a case of adult medulloblastoma associated with syringomyelia, which presented with paroxysmal bradycardia.

View Article: PubMed Central - PubMed

Affiliation: Nepean Hospital, Kingswood NSW 2747, Australia.

ABSTRACT
The association between cerebellar medulloblastoma and syringomyelia is uncommon and only found in pediatric patients. To date, adult medulloblastoma associated with syringomyelia has not been reported in the literature. Paroxysmal bradycardia is an uncommon clinical manifestation in posterior fossa tumors and likely to be vagally mediated via brainstem preganglionic cardiac motor neurons. This report introduces the diagnosis and treatment of a case of adult medulloblastoma associated with syringomyelia, which presented with paroxysmal bradycardia.

No MeSH data available.


Related in: MedlinePlus

Pre-operative sagittal T1-weighted image with gadolinium enhancement (A) and T2-weighted image (B) showing syringomyelic cavity and no spinal, leptomeningeal spread of tumor. Post-operative sagittal T1-weighted image (C) and T2-weighted image (D) showing the regression of the syrinx.
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f3: Pre-operative sagittal T1-weighted image with gadolinium enhancement (A) and T2-weighted image (B) showing syringomyelic cavity and no spinal, leptomeningeal spread of tumor. Post-operative sagittal T1-weighted image (C) and T2-weighted image (D) showing the regression of the syrinx.

Mentions: He was then transferred to an operating theater for the insertion of an external ventricular drain. Intracranial pressure was 32 cm of water, and CSF was intermittently drained to stabilize this pressure. Later, an MRI of the brain confirmed the CT findings of hydrocephalus and cerebellar tonsillar herniation (Figure 2). The extension of the lesion to the left foramen of Luschka was further demonstrated. An MRI of the spine revealed a syrinx extending from the C2 to T9 vertebrae and no leptomeningeal seeding (Figure 3). The tumor was subsequently removed via suboccipital approach, and histopathological studies demonstrated classic medulloblastoma.


Adult medulloblastoma associated with syringomyelia: a case report.

Wang CC - Cancer Biol Med (2012)

Pre-operative sagittal T1-weighted image with gadolinium enhancement (A) and T2-weighted image (B) showing syringomyelic cavity and no spinal, leptomeningeal spread of tumor. Post-operative sagittal T1-weighted image (C) and T2-weighted image (D) showing the regression of the syrinx.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3643653&req=5

f3: Pre-operative sagittal T1-weighted image with gadolinium enhancement (A) and T2-weighted image (B) showing syringomyelic cavity and no spinal, leptomeningeal spread of tumor. Post-operative sagittal T1-weighted image (C) and T2-weighted image (D) showing the regression of the syrinx.
Mentions: He was then transferred to an operating theater for the insertion of an external ventricular drain. Intracranial pressure was 32 cm of water, and CSF was intermittently drained to stabilize this pressure. Later, an MRI of the brain confirmed the CT findings of hydrocephalus and cerebellar tonsillar herniation (Figure 2). The extension of the lesion to the left foramen of Luschka was further demonstrated. An MRI of the spine revealed a syrinx extending from the C2 to T9 vertebrae and no leptomeningeal seeding (Figure 3). The tumor was subsequently removed via suboccipital approach, and histopathological studies demonstrated classic medulloblastoma.

Bottom Line: The association between cerebellar medulloblastoma and syringomyelia is uncommon and only found in pediatric patients.Paroxysmal bradycardia is an uncommon clinical manifestation in posterior fossa tumors and likely to be vagally mediated via brainstem preganglionic cardiac motor neurons.This report introduces the diagnosis and treatment of a case of adult medulloblastoma associated with syringomyelia, which presented with paroxysmal bradycardia.

View Article: PubMed Central - PubMed

Affiliation: Nepean Hospital, Kingswood NSW 2747, Australia.

ABSTRACT
The association between cerebellar medulloblastoma and syringomyelia is uncommon and only found in pediatric patients. To date, adult medulloblastoma associated with syringomyelia has not been reported in the literature. Paroxysmal bradycardia is an uncommon clinical manifestation in posterior fossa tumors and likely to be vagally mediated via brainstem preganglionic cardiac motor neurons. This report introduces the diagnosis and treatment of a case of adult medulloblastoma associated with syringomyelia, which presented with paroxysmal bradycardia.

No MeSH data available.


Related in: MedlinePlus