Limits...
Application of Real-time Ultrasound Elastography in Diagnosing Benign and Malignant Thyroid Solid Nodules.

Wang HL, Zhang S, Xin XJ, Zhao LH, Li CX, Mu JL, Wei XQ - Cancer Biol Med (2012)

Bottom Line: The SR of the benign lesions was 1.64±1.37, which was significantly different from that of malignant lesions, which was 4.96±2.13 (P<0.01).Both the ES and SR were higher in malignant nodules than those in benign ones.It can provide quantitative information on thyroid nodule characterization and improve diagnostic confidence.

View Article: PubMed Central - PubMed

Affiliation: Department of Ultrasonographic Diagnosis and Therapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.

ABSTRACT

Objective: Real-time ultrasound elastography (US-E) is a helpful tool in diagnosing thyroid nodules. This study aims to evaluate thyroid solid nodules, to establish the accuracy of US-E in providing information on the nature of these nodules, and to assess the clinical value of elasticity scores (ES) and strain ratio (SR) in differentiating thyroid solid nodules and to explore its distribution characteristics using pathological analysis as reference.

Methods: Traditional ultrasonography and US-E were performed on 131 thyroid solid nodules (99 benign ones and 32 malignant ones) in 120 patients (78 females and 41 males). Three radiologists evaluated the nodules based on a four-degree elasticity scoring system. The nodules were classified according to the ES as soft (ES 1-2) or hard (ES 3-4). The SR was calculated online.

Results: The sensitivity and specificity of the ES for thyroid cancer diagnosis were 78% and 80%, respectively. SR values ≥ 2.9 used as a standard to distinguish benign from malignant nodules had a sensitivity of 87% and a specificity of 92%. The SR of the benign lesions was 1.64±1.37, which was significantly different from that of malignant lesions, which was 4.96±2.13 (P<0.01).

Conclusions: Both the ES and SR were higher in malignant nodules than those in benign ones. Real-time US-E was a useful index in the differential diagnosis of thyroid solid nodules. It can provide quantitative information on thyroid nodule characterization and improve diagnostic confidence.

No MeSH data available.


Related in: MedlinePlus

A papillary carcinoma (follicular variant) with elasticity score of 4 in a 56-year-old woman. The average strain ratio of the nodule was 5.23.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3643650&req=5

f2: A papillary carcinoma (follicular variant) with elasticity score of 4 in a 56-year-old woman. The average strain ratio of the nodule was 5.23.

Mentions: Each nodule was assigned an elasticity score based on the pattern type according to the classification proposed by Fukunari [8]. Pattern 1 (score 1): most of the nodule is displayed in green. Pattern 2 (score 2): the center of the nodule is displayed in green and its peripheral part in blue. Pattern 3 (score 3): the nodule is displayed as a mixture of red, green, and blue. Pattern 4 (score 4): the entire nodule is displayed in blue (Figures 1 and 2).


Application of Real-time Ultrasound Elastography in Diagnosing Benign and Malignant Thyroid Solid Nodules.

Wang HL, Zhang S, Xin XJ, Zhao LH, Li CX, Mu JL, Wei XQ - Cancer Biol Med (2012)

A papillary carcinoma (follicular variant) with elasticity score of 4 in a 56-year-old woman. The average strain ratio of the nodule was 5.23.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3643650&req=5

f2: A papillary carcinoma (follicular variant) with elasticity score of 4 in a 56-year-old woman. The average strain ratio of the nodule was 5.23.
Mentions: Each nodule was assigned an elasticity score based on the pattern type according to the classification proposed by Fukunari [8]. Pattern 1 (score 1): most of the nodule is displayed in green. Pattern 2 (score 2): the center of the nodule is displayed in green and its peripheral part in blue. Pattern 3 (score 3): the nodule is displayed as a mixture of red, green, and blue. Pattern 4 (score 4): the entire nodule is displayed in blue (Figures 1 and 2).

Bottom Line: The SR of the benign lesions was 1.64±1.37, which was significantly different from that of malignant lesions, which was 4.96±2.13 (P<0.01).Both the ES and SR were higher in malignant nodules than those in benign ones.It can provide quantitative information on thyroid nodule characterization and improve diagnostic confidence.

View Article: PubMed Central - PubMed

Affiliation: Department of Ultrasonographic Diagnosis and Therapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.

ABSTRACT

Objective: Real-time ultrasound elastography (US-E) is a helpful tool in diagnosing thyroid nodules. This study aims to evaluate thyroid solid nodules, to establish the accuracy of US-E in providing information on the nature of these nodules, and to assess the clinical value of elasticity scores (ES) and strain ratio (SR) in differentiating thyroid solid nodules and to explore its distribution characteristics using pathological analysis as reference.

Methods: Traditional ultrasonography and US-E were performed on 131 thyroid solid nodules (99 benign ones and 32 malignant ones) in 120 patients (78 females and 41 males). Three radiologists evaluated the nodules based on a four-degree elasticity scoring system. The nodules were classified according to the ES as soft (ES 1-2) or hard (ES 3-4). The SR was calculated online.

Results: The sensitivity and specificity of the ES for thyroid cancer diagnosis were 78% and 80%, respectively. SR values ≥ 2.9 used as a standard to distinguish benign from malignant nodules had a sensitivity of 87% and a specificity of 92%. The SR of the benign lesions was 1.64±1.37, which was significantly different from that of malignant lesions, which was 4.96±2.13 (P<0.01).

Conclusions: Both the ES and SR were higher in malignant nodules than those in benign ones. Real-time US-E was a useful index in the differential diagnosis of thyroid solid nodules. It can provide quantitative information on thyroid nodule characterization and improve diagnostic confidence.

No MeSH data available.


Related in: MedlinePlus