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Activity of angiogenesis inhibitors in metastatic epithelioid hemangioendothelioma: a case report.

Gaur S, Torabi A, O'Neill TJ - Cancer Biol Med (2012)

Bottom Line: This report describes a patient with metastatic epithelioid hemangioendothelioma treated with bevacizumab and nanoparticle albumin-bound paclitaxel.The treatment was well tolerated and led to the stabilization of an aggressive variant of the disease.Literature describing the activity of bevacizumab and other agents (thalidomide, lenalidomide, and interferon) believed to possess anti-angiogenic activities is also reviewed.

View Article: PubMed Central - PubMed

Affiliation: Divisions of Hematology-Oncology, Texas Tech University Health Science Center, TX 79905, USA.

ABSTRACT
This report describes a patient with metastatic epithelioid hemangioendothelioma treated with bevacizumab and nanoparticle albumin-bound paclitaxel. The treatment was well tolerated and led to the stabilization of an aggressive variant of the disease. This case report is the first one that describes the activity of the combination of chemotherapy and bevacizumab in epithelioid hemangioendothelioma. Literature describing the activity of bevacizumab and other agents (thalidomide, lenalidomide, and interferon) believed to possess anti-angiogenic activities is also reviewed.

No MeSH data available.


Related in: MedlinePlus

A: CT scan (coronal view) showing a mass in the anterior and superior mediastinum containing a solid-enhancing component, coarse calcification, and fat. The mass involves the superior vena cava and right brachiocephalic vein. B: CT scan after 6 months showing stable appearance.
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f1: A: CT scan (coronal view) showing a mass in the anterior and superior mediastinum containing a solid-enhancing component, coarse calcification, and fat. The mass involves the superior vena cava and right brachiocephalic vein. B: CT scan after 6 months showing stable appearance.

Mentions: A 35-year old Hispanic male presented with a 12-month history of cough, shortness of breath, and pain involving the chest wall, lower back, and both legs. He lost 10 kg of his body weight over this time period. He did not smoke and had no other significant medical history. Physical examination was remarkable for 88% oxygen saturation in room air. He had crackles in both lung fields. Computed tomography (CT) of the thorax (Figure 1A) showed a heterogeneous mass in the superior and anterior mediastinum that involved the superior vena cava and right brachiocephalic vein. Innumerable 1-2 cm pulmonary nodules were present in both lung fields. A bone scan showed extensive metastatic disease in the calvarium, sternum, ribs, pelvis, spine, and femur. Magnetic resonance imaging of the head did not show brain involvement. CT-guided core biopsy of the mediastinal mass showed nests of rounded and slightly spindled epithelioid cells embedded in a myxoid matrix. Immunostains were positive for CD31 and CD34, consistent with EHE (Figure 2). The alpha-fetoprotein and beta-human chorionic gonadotropin levels were normal.


Activity of angiogenesis inhibitors in metastatic epithelioid hemangioendothelioma: a case report.

Gaur S, Torabi A, O'Neill TJ - Cancer Biol Med (2012)

A: CT scan (coronal view) showing a mass in the anterior and superior mediastinum containing a solid-enhancing component, coarse calcification, and fat. The mass involves the superior vena cava and right brachiocephalic vein. B: CT scan after 6 months showing stable appearance.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3643649&req=5

f1: A: CT scan (coronal view) showing a mass in the anterior and superior mediastinum containing a solid-enhancing component, coarse calcification, and fat. The mass involves the superior vena cava and right brachiocephalic vein. B: CT scan after 6 months showing stable appearance.
Mentions: A 35-year old Hispanic male presented with a 12-month history of cough, shortness of breath, and pain involving the chest wall, lower back, and both legs. He lost 10 kg of his body weight over this time period. He did not smoke and had no other significant medical history. Physical examination was remarkable for 88% oxygen saturation in room air. He had crackles in both lung fields. Computed tomography (CT) of the thorax (Figure 1A) showed a heterogeneous mass in the superior and anterior mediastinum that involved the superior vena cava and right brachiocephalic vein. Innumerable 1-2 cm pulmonary nodules were present in both lung fields. A bone scan showed extensive metastatic disease in the calvarium, sternum, ribs, pelvis, spine, and femur. Magnetic resonance imaging of the head did not show brain involvement. CT-guided core biopsy of the mediastinal mass showed nests of rounded and slightly spindled epithelioid cells embedded in a myxoid matrix. Immunostains were positive for CD31 and CD34, consistent with EHE (Figure 2). The alpha-fetoprotein and beta-human chorionic gonadotropin levels were normal.

Bottom Line: This report describes a patient with metastatic epithelioid hemangioendothelioma treated with bevacizumab and nanoparticle albumin-bound paclitaxel.The treatment was well tolerated and led to the stabilization of an aggressive variant of the disease.Literature describing the activity of bevacizumab and other agents (thalidomide, lenalidomide, and interferon) believed to possess anti-angiogenic activities is also reviewed.

View Article: PubMed Central - PubMed

Affiliation: Divisions of Hematology-Oncology, Texas Tech University Health Science Center, TX 79905, USA.

ABSTRACT
This report describes a patient with metastatic epithelioid hemangioendothelioma treated with bevacizumab and nanoparticle albumin-bound paclitaxel. The treatment was well tolerated and led to the stabilization of an aggressive variant of the disease. This case report is the first one that describes the activity of the combination of chemotherapy and bevacizumab in epithelioid hemangioendothelioma. Literature describing the activity of bevacizumab and other agents (thalidomide, lenalidomide, and interferon) believed to possess anti-angiogenic activities is also reviewed.

No MeSH data available.


Related in: MedlinePlus