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Expression of Bmi-1, P16, and CD44v6 in Uterine Cervical Carcinoma and Its Clinical Significance.

Weng MY, Li L, Feng SY, Hong SJ - Cancer Biol Med (2012)

Bottom Line: Nevertheless, the positive expression of p16 protein in UCC was not significantly associated with the clinicopathologic features (P>0.05).The Kaplan-Meier survival analysis showed that the over-expression of Bmi-1 significantly decreased the survival rate of UCC patients (P<0.05).The positive expression of p16 protein is possibly associated with the tumorigenesis, but not with the metastasis or prognosis of UCC.

View Article: PubMed Central - PubMed

Affiliation: Department of Gynecology and Obstetrics, Sun Yat-sen Memorial Hospital of Zhongshan University, Guangzhou 510120, China.

ABSTRACT

Objective: Bmi-1, a putative proto-oncogene, is a core member of the polycomb gene family, which is expressed in many human tumors. The p16 protein negatively regulated cell proliferation, whereas CD44v6 is associated with proliferation as an important protein. Additionally, CD44v6 is an important nuclear antigen closely correlated to tumor metastasis. The present study aims to investigate the expression and significance of Bmi-1, p16, and CD44v6 in uterine cervical carcinoma (UCC).

Methods: A total of 62 UCC, 30 cervical neoplasic, and 20 normal cervical mucosal tissues were used in the current study. The expression of Bmi-1, p16, and CD44v6 in these tissues was determined using immunohistochemical assay. The relationships among the expression of these indices, the clinicopathologic features of UCC, and the survival rate of UCC patients were also discussed. The correlation between Bmi-1 protein expression and p16 or CD44v6 protein in UCC was analyzed.

Results: The expression of Bmi-1, p16, and CD44v6 was significantly high in cervical carcinoma compared with that in the cervical neoplasia and normal colorectal mucosa (P<0.05). The over-expression of Bmi-1 protein in UCC was apparently related to the distant metastasis (P<0.01) and the tumor, nodes and metastasis-classification, i.e. the TNM staging, World Health Organization (P<0.05). Nevertheless, the positive expression of p16 protein in UCC was not significantly associated with the clinicopathologic features (P>0.05). The Kaplan-Meier survival analysis showed that the over-expression of Bmi-1 significantly decreased the survival rate of UCC patients (P<0.05). A strong correlation indicated that there was statistical significance between the expression of Bmi-1 and CD44V6 proteins in UCC (r=0.419, P=0.001).

Conclusions: The over-expression of Bmi-1 and CD44v6 protein closely correlate to the tumorigenesis, metastasis, and prognosis of UCC. Bmi-1 and CD44v6 may be used to predict the prognosis of cervical carcinoma. Bmi-1 may indirectly regulate the expression of CD44v6 in UCC patients. The positive expression of p16 protein is possibly associated with the tumorigenesis, but not with the metastasis or prognosis of UCC.

No MeSH data available.


Related in: MedlinePlus

Kaplan–Meier survival curves of UCC patients with various expression levels of Bmi-1 and CD44V6 proteins.
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f2: Kaplan–Meier survival curves of UCC patients with various expression levels of Bmi-1 and CD44V6 proteins.

Mentions: A Kaplan–Meier survival curve was used to analyze the relationship between the Bmi-1 protein expression and the survival rate of the 62 UCC patients. The log-rank test was then used to analyse the statistical significance between the survival rates of the two groups. The results indicated that the survival rate was obviously lower in patients with over-expression of Bmi-1 protein than in those with under-expression (χ2=12.03, P=0.001). The survival rate was apparently lower in the patients with over-expression of CD44v6 protein than in those with under-expression (χ2=19.228, P=0.001) (Figure 2).


Expression of Bmi-1, P16, and CD44v6 in Uterine Cervical Carcinoma and Its Clinical Significance.

Weng MY, Li L, Feng SY, Hong SJ - Cancer Biol Med (2012)

Kaplan–Meier survival curves of UCC patients with various expression levels of Bmi-1 and CD44V6 proteins.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3643647&req=5

f2: Kaplan–Meier survival curves of UCC patients with various expression levels of Bmi-1 and CD44V6 proteins.
Mentions: A Kaplan–Meier survival curve was used to analyze the relationship between the Bmi-1 protein expression and the survival rate of the 62 UCC patients. The log-rank test was then used to analyse the statistical significance between the survival rates of the two groups. The results indicated that the survival rate was obviously lower in patients with over-expression of Bmi-1 protein than in those with under-expression (χ2=12.03, P=0.001). The survival rate was apparently lower in the patients with over-expression of CD44v6 protein than in those with under-expression (χ2=19.228, P=0.001) (Figure 2).

Bottom Line: Nevertheless, the positive expression of p16 protein in UCC was not significantly associated with the clinicopathologic features (P>0.05).The Kaplan-Meier survival analysis showed that the over-expression of Bmi-1 significantly decreased the survival rate of UCC patients (P<0.05).The positive expression of p16 protein is possibly associated with the tumorigenesis, but not with the metastasis or prognosis of UCC.

View Article: PubMed Central - PubMed

Affiliation: Department of Gynecology and Obstetrics, Sun Yat-sen Memorial Hospital of Zhongshan University, Guangzhou 510120, China.

ABSTRACT

Objective: Bmi-1, a putative proto-oncogene, is a core member of the polycomb gene family, which is expressed in many human tumors. The p16 protein negatively regulated cell proliferation, whereas CD44v6 is associated with proliferation as an important protein. Additionally, CD44v6 is an important nuclear antigen closely correlated to tumor metastasis. The present study aims to investigate the expression and significance of Bmi-1, p16, and CD44v6 in uterine cervical carcinoma (UCC).

Methods: A total of 62 UCC, 30 cervical neoplasic, and 20 normal cervical mucosal tissues were used in the current study. The expression of Bmi-1, p16, and CD44v6 in these tissues was determined using immunohistochemical assay. The relationships among the expression of these indices, the clinicopathologic features of UCC, and the survival rate of UCC patients were also discussed. The correlation between Bmi-1 protein expression and p16 or CD44v6 protein in UCC was analyzed.

Results: The expression of Bmi-1, p16, and CD44v6 was significantly high in cervical carcinoma compared with that in the cervical neoplasia and normal colorectal mucosa (P<0.05). The over-expression of Bmi-1 protein in UCC was apparently related to the distant metastasis (P<0.01) and the tumor, nodes and metastasis-classification, i.e. the TNM staging, World Health Organization (P<0.05). Nevertheless, the positive expression of p16 protein in UCC was not significantly associated with the clinicopathologic features (P>0.05). The Kaplan-Meier survival analysis showed that the over-expression of Bmi-1 significantly decreased the survival rate of UCC patients (P<0.05). A strong correlation indicated that there was statistical significance between the expression of Bmi-1 and CD44V6 proteins in UCC (r=0.419, P=0.001).

Conclusions: The over-expression of Bmi-1 and CD44v6 protein closely correlate to the tumorigenesis, metastasis, and prognosis of UCC. Bmi-1 and CD44v6 may be used to predict the prognosis of cervical carcinoma. Bmi-1 may indirectly regulate the expression of CD44v6 in UCC patients. The positive expression of p16 protein is possibly associated with the tumorigenesis, but not with the metastasis or prognosis of UCC.

No MeSH data available.


Related in: MedlinePlus