Limits...
Meta-Analysis of the Association between Mir-196a-2 Polymorphism and Cancer Susceptibility.

Zhang H, Su YL, Yu H, Qian BY - Cancer Biol Med (2012)

Bottom Line: In the subgroup analysis of different tumor types, the C allele was associated with increased risk of lung, breast, and colorectal cancer, but not with liver, gastric, or esophageal cancer.In the subgroup analysis by ethnicity, a significantly increased risk of cancer was found among Asians in all genetic models, but no associations were found in the Caucasian subgroup.The meta-analysis demonstrated that the miR-196a-2 polymorphism is associated with cancer susceptibility, especially lung cancer, colorectal cancer, and breast cancer among Asian populations.

View Article: PubMed Central - PubMed

Affiliation: Department of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China ; Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China.

ABSTRACT

Objective: MicroRNA plays a vital role in gene expression, and microRNA dysregulation is involved in carcinogenesis. The miR-196a-2 polymorphism rs11614913 is reportedly associated with cancer susceptibility. This meta-analysis was performed to assess the overall association of miR-196a-2 with cancer risk.

Methods: A total of 27 independent case-control studies involving 10,435 cases and 12,075 controls were analyzed for the rs11614913 polymorphism.

Results: A significant association was found between rs11614913 polymorphism and cancer risk in four genetic models (CT vs. TT, OR=1.15, 95%CI=1.05-1.27; CC vs. TT, OR=1.23, 95%CI=1.08-1.39; Dominant model, OR=1.17, 95%CI=1.06-1.30; Additive model, OR=1.08, 95%CI=1.01-1.14). In the subgroup analysis of different tumor types, the C allele was associated with increased risk of lung, breast, and colorectal cancer, but not with liver, gastric, or esophageal cancer. In the subgroup analysis by ethnicity, a significantly increased risk of cancer was found among Asians in all genetic models, but no associations were found in the Caucasian subgroup.

Conclusions: The meta-analysis demonstrated that the miR-196a-2 polymorphism is associated with cancer susceptibility, especially lung cancer, colorectal cancer, and breast cancer among Asian populations.

No MeSH data available.


Related in: MedlinePlus

miR-196a-2 rs11614913 MAF distribution in different ethnicity.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3643645&req=5

f2: miR-196a-2 rs11614913 MAF distribution in different ethnicity.

Mentions: Minor allele frequencies (MAF) were calculated in the control groups of each study to estimate the racial difference. Figure 2 shows the significant difference (C as the minor allele) in MAF distribution of miR-196a-2 rs11614913 T>C polymorphism among the controls of the different races: Asians and Caucasians. Specifically, the mean MAF in 17 Asian studies was 0.451±0.013. The mean MAF was 0.637+0.020 in the 10 Caucasian studies. The distribution of rs11614913 genotypes in the control subjects followed the HWE in all studies except 2, reported by Mittal et al. [37] and by George et al. [38] (Table 1).


Meta-Analysis of the Association between Mir-196a-2 Polymorphism and Cancer Susceptibility.

Zhang H, Su YL, Yu H, Qian BY - Cancer Biol Med (2012)

miR-196a-2 rs11614913 MAF distribution in different ethnicity.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3643645&req=5

f2: miR-196a-2 rs11614913 MAF distribution in different ethnicity.
Mentions: Minor allele frequencies (MAF) were calculated in the control groups of each study to estimate the racial difference. Figure 2 shows the significant difference (C as the minor allele) in MAF distribution of miR-196a-2 rs11614913 T>C polymorphism among the controls of the different races: Asians and Caucasians. Specifically, the mean MAF in 17 Asian studies was 0.451±0.013. The mean MAF was 0.637+0.020 in the 10 Caucasian studies. The distribution of rs11614913 genotypes in the control subjects followed the HWE in all studies except 2, reported by Mittal et al. [37] and by George et al. [38] (Table 1).

Bottom Line: In the subgroup analysis of different tumor types, the C allele was associated with increased risk of lung, breast, and colorectal cancer, but not with liver, gastric, or esophageal cancer.In the subgroup analysis by ethnicity, a significantly increased risk of cancer was found among Asians in all genetic models, but no associations were found in the Caucasian subgroup.The meta-analysis demonstrated that the miR-196a-2 polymorphism is associated with cancer susceptibility, especially lung cancer, colorectal cancer, and breast cancer among Asian populations.

View Article: PubMed Central - PubMed

Affiliation: Department of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China ; Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China.

ABSTRACT

Objective: MicroRNA plays a vital role in gene expression, and microRNA dysregulation is involved in carcinogenesis. The miR-196a-2 polymorphism rs11614913 is reportedly associated with cancer susceptibility. This meta-analysis was performed to assess the overall association of miR-196a-2 with cancer risk.

Methods: A total of 27 independent case-control studies involving 10,435 cases and 12,075 controls were analyzed for the rs11614913 polymorphism.

Results: A significant association was found between rs11614913 polymorphism and cancer risk in four genetic models (CT vs. TT, OR=1.15, 95%CI=1.05-1.27; CC vs. TT, OR=1.23, 95%CI=1.08-1.39; Dominant model, OR=1.17, 95%CI=1.06-1.30; Additive model, OR=1.08, 95%CI=1.01-1.14). In the subgroup analysis of different tumor types, the C allele was associated with increased risk of lung, breast, and colorectal cancer, but not with liver, gastric, or esophageal cancer. In the subgroup analysis by ethnicity, a significantly increased risk of cancer was found among Asians in all genetic models, but no associations were found in the Caucasian subgroup.

Conclusions: The meta-analysis demonstrated that the miR-196a-2 polymorphism is associated with cancer susceptibility, especially lung cancer, colorectal cancer, and breast cancer among Asian populations.

No MeSH data available.


Related in: MedlinePlus