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Meta-Analysis of the Association between Mir-196a-2 Polymorphism and Cancer Susceptibility.

Zhang H, Su YL, Yu H, Qian BY - Cancer Biol Med (2012)

Bottom Line: In the subgroup analysis of different tumor types, the C allele was associated with increased risk of lung, breast, and colorectal cancer, but not with liver, gastric, or esophageal cancer.In the subgroup analysis by ethnicity, a significantly increased risk of cancer was found among Asians in all genetic models, but no associations were found in the Caucasian subgroup.The meta-analysis demonstrated that the miR-196a-2 polymorphism is associated with cancer susceptibility, especially lung cancer, colorectal cancer, and breast cancer among Asian populations.

View Article: PubMed Central - PubMed

Affiliation: Department of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China ; Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China.

ABSTRACT

Objective: MicroRNA plays a vital role in gene expression, and microRNA dysregulation is involved in carcinogenesis. The miR-196a-2 polymorphism rs11614913 is reportedly associated with cancer susceptibility. This meta-analysis was performed to assess the overall association of miR-196a-2 with cancer risk.

Methods: A total of 27 independent case-control studies involving 10,435 cases and 12,075 controls were analyzed for the rs11614913 polymorphism.

Results: A significant association was found between rs11614913 polymorphism and cancer risk in four genetic models (CT vs. TT, OR=1.15, 95%CI=1.05-1.27; CC vs. TT, OR=1.23, 95%CI=1.08-1.39; Dominant model, OR=1.17, 95%CI=1.06-1.30; Additive model, OR=1.08, 95%CI=1.01-1.14). In the subgroup analysis of different tumor types, the C allele was associated with increased risk of lung, breast, and colorectal cancer, but not with liver, gastric, or esophageal cancer. In the subgroup analysis by ethnicity, a significantly increased risk of cancer was found among Asians in all genetic models, but no associations were found in the Caucasian subgroup.

Conclusions: The meta-analysis demonstrated that the miR-196a-2 polymorphism is associated with cancer susceptibility, especially lung cancer, colorectal cancer, and breast cancer among Asian populations.

No MeSH data available.


Related in: MedlinePlus

Flow diagram of the identification of studies.
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f1: Flow diagram of the identification of studies.

Mentions: A total of 39 articles were initially identified through database searches using different key words and their combinations. After reading the titles and abstracts of the identified articles, the studies that did not meet the inclusion criteria were excluded. During data extraction, additional articles that did not have allelic frequencies available for analysis were also disqualified. Eligible studies were retrieved for detailed full-text evaluation. Manual searches were also done and one relevant article from the references of selected studies was identified. Finally, 27 independent case-control studies [14-40], involving 10,435 cases and 12,075 controls, were included in the meta-analysis for rs11614913. Figure 1 shows the identification and selection of studies.


Meta-Analysis of the Association between Mir-196a-2 Polymorphism and Cancer Susceptibility.

Zhang H, Su YL, Yu H, Qian BY - Cancer Biol Med (2012)

Flow diagram of the identification of studies.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3643645&req=5

f1: Flow diagram of the identification of studies.
Mentions: A total of 39 articles were initially identified through database searches using different key words and their combinations. After reading the titles and abstracts of the identified articles, the studies that did not meet the inclusion criteria were excluded. During data extraction, additional articles that did not have allelic frequencies available for analysis were also disqualified. Eligible studies were retrieved for detailed full-text evaluation. Manual searches were also done and one relevant article from the references of selected studies was identified. Finally, 27 independent case-control studies [14-40], involving 10,435 cases and 12,075 controls, were included in the meta-analysis for rs11614913. Figure 1 shows the identification and selection of studies.

Bottom Line: In the subgroup analysis of different tumor types, the C allele was associated with increased risk of lung, breast, and colorectal cancer, but not with liver, gastric, or esophageal cancer.In the subgroup analysis by ethnicity, a significantly increased risk of cancer was found among Asians in all genetic models, but no associations were found in the Caucasian subgroup.The meta-analysis demonstrated that the miR-196a-2 polymorphism is associated with cancer susceptibility, especially lung cancer, colorectal cancer, and breast cancer among Asian populations.

View Article: PubMed Central - PubMed

Affiliation: Department of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China ; Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China.

ABSTRACT

Objective: MicroRNA plays a vital role in gene expression, and microRNA dysregulation is involved in carcinogenesis. The miR-196a-2 polymorphism rs11614913 is reportedly associated with cancer susceptibility. This meta-analysis was performed to assess the overall association of miR-196a-2 with cancer risk.

Methods: A total of 27 independent case-control studies involving 10,435 cases and 12,075 controls were analyzed for the rs11614913 polymorphism.

Results: A significant association was found between rs11614913 polymorphism and cancer risk in four genetic models (CT vs. TT, OR=1.15, 95%CI=1.05-1.27; CC vs. TT, OR=1.23, 95%CI=1.08-1.39; Dominant model, OR=1.17, 95%CI=1.06-1.30; Additive model, OR=1.08, 95%CI=1.01-1.14). In the subgroup analysis of different tumor types, the C allele was associated with increased risk of lung, breast, and colorectal cancer, but not with liver, gastric, or esophageal cancer. In the subgroup analysis by ethnicity, a significantly increased risk of cancer was found among Asians in all genetic models, but no associations were found in the Caucasian subgroup.

Conclusions: The meta-analysis demonstrated that the miR-196a-2 polymorphism is associated with cancer susceptibility, especially lung cancer, colorectal cancer, and breast cancer among Asian populations.

No MeSH data available.


Related in: MedlinePlus